Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Dhammika H. M. L. P. Navarathna"'
Autor:
Dhammika H M L P Navarathna, Ruvini U Pathirana, Michail S Lionakis, Kenneth W Nickerson, David D Roberts
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164449 (2016)
Formation of chlamydospores by Candida albicans was an established medical diagnostic test to confirm candidiasis before the molecular era. However, the functional role and pathological relevance of this in vitro morphological transition to pathogene
Externí odkaz:
https://doaj.org/article/b2df3349f7054a37a4604117b0221050
Autor:
Dhammika H M L P Navarathna, Erica V Stein, Elizabeth C Lessey-Morillon, Debasis Nayak, Gema Martin-Manso, David D Roberts
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0128220 (2015)
CD47 is a widely expressed receptor that regulates immunity by engaging its counter-receptor SIRPα on phagocytes and its secreted ligand thrombospondin-1. Mice lacking CD47 can exhibit enhanced or impaired host responses to bacterial pathogens, but
Externí odkaz:
https://doaj.org/article/f37aa01e76a9467998d376fd72887538
Autor:
Gema Martin-Manso, Dhammika H M L P Navarathna, Susana Galli, David R Soto-Pantoja, Svetlana A Kuznetsova, Maria Tsokos, David D Roberts
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48775 (2012)
Disseminated Candida albicans infection results in high morbidity and mortality despite treatment with existing antifungal drugs. Recent studies suggest that modulating the host immune response can improve survival, but specific host targets for acco
Externí odkaz:
https://doaj.org/article/dee293d1581c4a6c8ed838e05731aaa6
Autor:
Dhammika H M L P Navarathna, Michail S Lionakis, Martin J Lizak, Jeeva Munasinghe, Kenneth W Nickerson, David D Roberts
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48475 (2012)
The intracellular enzyme urea amidolyase (Dur1,2p) enables C. albicans to utilize urea as a sole nitrogen source. Because deletion of the DUR1,2 gene reduces survival of C. albicans co-cultured with a murine macrophage cell line, we investigated the
Externí odkaz:
https://doaj.org/article/8aab9286181c4cd9ba2f2cb035191fca
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0223919 (2019)
PLoS ONE, Vol 14, Iss 10, p e0223919 (2019)
Three isoforms of nitric oxide synthase (NOS) occur in mammals. High levels of NO produced by NOS2/iNOS can protect against bacterial and parasitic infections, but the role of NOS in fungal innate immunity is less clear. Compared to wild type mice, N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a5cd3597996d3e17f79ba5a77e255cc
http://europepmc.org/articles/PMC6822743
http://europepmc.org/articles/PMC6822743
Autor:
Martin J. Lizak, Dorian B. McGavern, Jeeva Munasinghe, David D. Roberts, Dhammika H. M. L. P. Navarathna, Debasis Nayak
Publikováno v:
NMR in Biomedicine. 26:1125-1134
Disseminated candidiasis primarily targets the kidneys and brain in mice and humans. Damage to these critical organs leads to the high mortality associated with such infections, and invasion across the blood-brain barrier can result in fungal meningo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3256a0fc9a32f672189d1af723ab43ac
https://doi.org/10.1002/nbm.2926
https://doi.org/10.1002/nbm.2926
Autor:
Michail S. Lionakis, David D. Roberts, Dhammika H. M. L. P. Navarathna, Ruvini U. Pathirana, Kenneth W. Nickerson
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164449 (2016)
PLoS ONE, Vol 11, Iss 10, p e0164449 (2016)
Formation of chlamydospores by Candida albicans was an established medical diagnostic test to confirm candidiasis before the molecular era. However, the functional role and pathological relevance of this in vitro morphological transition to pathogene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1b4b8b0610bbda63007c0a44050d129
http://europepmc.org/articles/PMC5058487
http://europepmc.org/articles/PMC5058487
Publikováno v:
FEMS Yeast Research. 10:209-213
The higher fungi exhibit a dichotomy with regard to urea utilization. The hemiascomycetes use urea amidolyase (DUR1,2), whereas all other higher fungi use the nickel-containing urease. Urea amidolyase is an energy-dependent biotin-containing enzyme.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ed372ce86a4f1f782223158701431db
https://doi.org/10.1111/j.1567-1364.2009.00602.x
https://doi.org/10.1111/j.1567-1364.2009.00602.x
Autor:
David D. Roberts, Audrey L. Atkin, Kenneth W. Nickerson, Jake T. Cooper, Thomas M. Petro, Dhammika H. M. L. P. Navarathna, Suman Ghosh
Publikováno v:
Infection and Immunity. 77:1596-1605
The opportunistic fungal pathogen Candida albicans is a part of the normal flora but it also causes systemic candidiasis if it reaches the bloodstream. Upon being phagocytized by macrophages, an important component of innate immunity, C. albicans rap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1b7e537b4c1c57675a4f251264929ed
https://doi.org/10.1128/iai.01452-08
https://doi.org/10.1128/iai.01452-08
Autor:
Audrey L. Atkin, Bessie W. Kebaara, Raluca Dumitru, Dhammika H. M. L. P. Navarathna, Kenneth W. Nickerson, Melanie L. Langford
Publikováno v:
Eukaryotic Cell. 7:980-987
Candida albicans is a dimorphic fungus that can interconvert between yeast and filamentous forms. Its ability to regulate morphogenesis is strongly correlated with virulence. Tup1, a transcriptional repressor, and the signaling molecule farnesol are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bf41faafcde927141448a4e6974528
https://doi.org/10.1128/ec.00357-07
https://doi.org/10.1128/ec.00357-07