Mechanistic and thermodynamic characterization of antiviral inhibitors targeting nucleocapsid N-terminal domain of SARS-CoV-2

Autor: Dhaka, Preeti, Singh, Ankur, Choudhary, Shweta, Peddinti, Rama Krishna, Kumar, Pravindra, Sharma, Gaurav Kumar, Tomar, Shailly

Publikováno v: In Archives of Biochemistry and Biophysics December 2023 750

Multi-target direct-acting SARS-CoV-2 antivirals against the nucleotide-binding pockets of virus-specific proteins

Autor: Rani, Ruchi, Long, Siwen, Pareek, Akshay, Dhaka, Preeti, Singh, Ankur, Kumar, Pravindra, McInerney, Gerald, Tomar, Shailly

Publikováno v: In Virology December 2022 577:1-15

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Structural and biochemical analyses reveal quinic acid inhibits DAHP synthase a key player in shikimate pathway.

Autor: Jangid K; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India., Mahto JK; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India., Kumar KA; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India., Dhaka P; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India., Sharma A; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India., Tariq A; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India., Sharma AK; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India. Electronic address: ashwani.sharma@bt.iitr.ac.in., Kumar P; Department of Biosciences and Bioengineering, IIT Roorkee, Roorkee, India. Electronic address: pravindra.kumar@bt.iitr.ac.in.

Publikováno v: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2024 Nov 19; Vol. 763, pp. 110219. Date of Electronic Publication: 2024 Nov 19.