Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Dhaarmini Rajshankar"'
Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen
Autor:
Lisa A. Staudinger, Stephen J. Spano, Wilson Lee, Nuno Coelho, Dhaarmini Rajshankar, Michelle P. Bendeck, Tara Moriarty, Christopher A. McCulloch
Publikováno v:
Biology Open, Vol 2, Iss 11, Pp 1148-1159 (2013)
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and dis
Externí odkaz:
https://doaj.org/article/5401010204bf444e9e19d56465575104
Autor:
Dhaarmini Rajshankar, Corneliu Sima, Qin Wang, Stephanie R Goldberg, Mwayi Kazembe, Yongqiang Wang, Michael Glogauer, Gregory P Downey, Christopher A McCulloch
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70659 (2013)
IL-1β contributes to connective tissue destruction in part by up-regulating stromelysin-1 (MMP-3), which in fibroblasts is a focal adhesion-dependent process. Protein tyrosine phosphatase-α (PTPα) is enriched in and regulates the formation of foca
Externí odkaz:
https://doaj.org/article/92891653f42c431294dc09228d2a5717
Autor:
Christopher A. McCulloch, Baiyu Wang, Yongqiang Wang, Dhaarmini Rajshankar, Elizabeth Worndl, Sara Menezes
Publikováno v:
Journal of cellular physiology. 235(3)
Focal adhesion kinase (FAK) is critical for collagen expression but its regulation of collagen remodeling is not defined. We examined the role of FAK in the degradation and reorganization of fibrillar collagen. Compared with wild-type (WT) mouse embr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f630470ad0163a4d544f9331ef32d6e
https://pubmed.ncbi.nlm.nih.gov/31556111
https://pubmed.ncbi.nlm.nih.gov/31556111
Publikováno v:
The FASEB Journal. 31:937-953
Focal adhesion kinase (FAK) is critical in adhesion-dependent signaling, but its role in osteogenesis in vivo is ill defined. We deleted Fak in fibroblasts and osteoblasts in Floxed-Fak mice bred with those expressing Cre-recombinase driven by 3.6-kb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f89ec14fa0d77f3176838a818b1ec3
https://doi.org/10.1096/fj.201600645r
https://doi.org/10.1096/fj.201600645r
Publikováno v:
Experimental Cell Research. 328:172-185
The application of nanotechnology for drug targeting underlines the importance of controlling the kinetics and cellular sites of delivery for optimal therapeutic outcomes. Here we examined the effect of particle size on internalization and degradatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2dfb4072347c68df85bf728f7fd6f1
https://doi.org/10.1016/j.yexcr.2014.06.018
https://doi.org/10.1016/j.yexcr.2014.06.018
Autor:
Christopher A. McCulloch, Ilana Talior-Volodarsky, Carol Laschinger, Dhaarmini Rajshankar, Gregory P. Downey, Yongqiang Wang, Qin Wang
Publikováno v:
Journal of Biological Chemistry. 285:22308-22317
Interleukin-1 (IL-1) induces extracellular matrix degradation as a result of increased expression of matrix metalloproteinases (MMPs). We examined adhesion-restricted signaling pathways that enable IL-1-induced MMP release in human gingival and murin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb0da306f1e7a5dedb5ed16f60e0ce4
https://doi.org/10.1074/jbc.m110.102426
https://doi.org/10.1074/jbc.m110.102426
Autor:
Gregory P. Downey, Dhaarmini Rajshankar, Christopher A. McCulloch, Qin Wang, Yongqiang Wang, Dominik Fritz
Publikováno v:
The Journal of biological chemistry. 289(26)
Interleukin-1 (IL-1) signaling in fibroblasts is mediated through focal adhesions, organelles that are enriched with adaptor and cytoskeletal proteins that regulate signal transduction. We examined interactions of the focal adhesion kinase (FAK) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be391ba96671326118dcde0f55ce2e7
https://pubmed.ncbi.nlm.nih.gov/24821720
https://pubmed.ncbi.nlm.nih.gov/24821720
Autor:
Gregory P. Downey, Christopher A. McCulloch, Mwayi P. Kazembe, Qin Wang, Stephanie Goldberg, Yongqiang Wang, Michael Glogauer, Dhaarmini Rajshankar, Corneliu Sima
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 8, p e70659 (2013)
PLoS ONE, Vol 8, Iss 8, p e70659 (2013)
IL-1β contributes to connective tissue destruction in part by up-regulating stromelysin-1 (MMP-3), which in fibroblasts is a focal adhesion-dependent process. Protein tyrosine phosphatase-α (PTPα) is enriched in and regulates the formation of foca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d48b87996e0bd26047d386039336d7a
http://europepmc.org/articles/PMC3734242
http://europepmc.org/articles/PMC3734242
Interactions between the discoidin domain receptor 1 and β1 integrin regulate attachment to collagen
Autor:
Wilson Lee, Lisa A. Staudinger, Stephen J. Spano, Michelle P. Bendeck, Nuno M. Coelho, Dhaarmini Rajshankar, Christopher A. McCulloch, Tara J. Moriarty
Publikováno v:
Biology Open
Biology Open, Vol 2, Iss 11, Pp 1148-1159 (2013)
Biology Open, Vol 2, Iss 11, Pp 1148-1159 (2013)
Summary Collagen degradation by phagocytosis is essential for physiological collagen turnover and connective tissue homeostasis. The rate limiting step of phagocytosis is the binding of specific adhesion receptors, which include the integrins and dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c9e1f579553330a02e50d927a4d921
https://pubmed.ncbi.nlm.nih.gov/24244851
https://pubmed.ncbi.nlm.nih.gov/24244851
IL-1β is a prominent proinflammatory cytokine that mediates degradation of extracellular matrix proteins through increased expression of matrix metalloproteinases, which involves a signaling pathway in adherent cells that is restricted by focal adhe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4814214d2600a0dbf6a8538f731485f2
https://europepmc.org/articles/PMC3475244/
https://europepmc.org/articles/PMC3475244/
