Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Dezhuang Ye"'
Publikováno v:
EBioMedicine, Vol 84, Iss , Pp 104277- (2022)
Summary: Background: Adeno-associated viral (AAV) vectors are currently the leading platform for gene therapy with the potential to treat a variety of central nervous system (CNS) diseases. There are numerous methods for delivering AAVs to the CNS, s
Externí odkaz:
https://doaj.org/article/f69e3402a9484c9c9bfb8b1fbe6d7d2a
Autor:
Yaoheng Yang, Christopher Pham Pacia, Dezhuang Ye, Lifei Zhu, Hongchae Baek, Yimei Yue, Jinyun Yuan, Mark J. Miller, Jianmin Cui, Joseph P. Culver, Michael R. Bruchas, Hong Chen
Publikováno v:
Brain Stimulation, Vol 14, Iss 4, Pp 790-800 (2021)
Background: Critical advances in the investigation of brain functions and treatment of brain disorders are hindered by our inability to selectively target neurons in a noninvasive manner in the deep brain. Objective: This study aimed to develop sonot
Externí odkaz:
https://doaj.org/article/83713878b06a43d78a4ea42aedf8bcf6
Publikováno v:
Frontiers in Physics, Vol 9 (2021)
Immune checkpoint inhibitors (ICIs) are designed to reinvigorate antitumor immune responses by interrupting inhibitory signaling pathways and promote the immune-mediated elimination of malignant cells. Although ICI therapy has transformed the landsca
Externí odkaz:
https://doaj.org/article/6245d8f3895b41b4b7fd84f7129cd3a4
Autor:
Dezhuang Ye, Hong Chen
Publikováno v:
MethodsX, Vol 8, Iss , Pp 101266- (2021)
The blood-brain barrier (BBB) is the major obstacle for brain drug delivery and limits the treatment options for central nervous system diseases. To circumvent the BBB, we introduce focused ultrasound-mediated intranasal brain drug delivery (FUSIN).
Externí odkaz:
https://doaj.org/article/1f8b8408415d4c87a8b2be033fe9e266
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 190 (2021)
Immune checkpoint inhibitors have great potential for the treatment of gliomas; however, their therapeutic efficacy has been partially limited by their inability to efficiently cross the blood–brain barrier (BBB). The objective of this study was to
Externí odkaz:
https://doaj.org/article/0f33a040e1e64161b6033e9b26755c0c
Autor:
Zhongtao Hu, Yaoheng Yang, Leqi Yang, Yan Gong, Chinwendu Chukwu, Dezhuang Ye, Yimei Yue, Jinyun Yuan, Kravitz, Alexxai V., Hong Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 6/25/2024, Vol. 121 Issue 26, p1-12, 18p
Publikováno v:
IEEE transactions on bio-medical engineering. 69(11)
Diffuse intrinsic pontine glioma (DIPG) is the most common and deadliest brainstem tumor in children. Focused ultrasound combined with microbubble-mediated BBB opening (FUS-BBBO) is a promising technique for overcoming the frequently intact blood-bra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3b17968cff32e42b7fb5d2b03746f3
https://pubmed.ncbi.nlm.nih.gov/35476579
https://pubmed.ncbi.nlm.nih.gov/35476579
Autor:
Yaoheng Yang, Jinyun Yuan, Rachael L. Field, Dezhuang Ye, Zhongtao Hu, Kevin Xu, Lu Xu, Yan Gong, Yimei Yue, Alexxai V. Kravitz, Michael R. Bruchas, Jianmin Cui, Jonathan R. Brestoff, Hong Chen
Publikováno v:
Nature Metabolism.
Torpor is an energy-conserving state in which animals dramatically decrease their metabolic rate and body temperature to survive harsh environmental conditions. Here, we report the noninvasive, precise and safe induction of a torpor-like hypothermic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::509229a7b3feaa0fc8926787b4bd3889
https://doi.org/10.1038/s42255-023-00804-z
https://doi.org/10.1038/s42255-023-00804-z
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The glymphatic system is a perivascular fluid transport system for waste clearance. Glymphatic transport is believed to be driven by the perivascular pumping effect created by the pulsation of the arterial wall caused by the cardiac cycle. Ultrasound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3680eedd8886f035c7e073de1a6c7a75
https://doi.org/10.1073/pnas.2212933120
https://doi.org/10.1073/pnas.2212933120
Autor:
Christopher Pham Pacia, Dezhuang Ye, Lu Xu, Yan Gong, Chih-Yen Chien, Hong Chen, Zhongtao Hu, Yaoheng Yang
Publikováno v:
IEEE Trans Ultrason Ferroelectr Freq Control
Cavitation is the fundamental physical mechanism of various focused ultrasound (FUS)-mediated therapies in the brain. Accurately knowing the three-dimensional (3-D) location of cavitation in real-time can improve the targeting accuracy and avoid off-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c9081acdfa761ecfe528230c03f1d3
https://doi.org/10.1109/tuffc.2021.3091950
https://doi.org/10.1109/tuffc.2021.3091950