Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities

Autor: Deyhim Atarod, Fatemeh Mamashli, Atiyeh Ghasemi, Faezeh Moosavi-Movahedi, Mitra Pirhaghi, Hadi Nedaei, Vladimir Muronetz, Thomas Haertlé, Jörg Tatzelt, Gholamhossein Riazi, Ali Akbar Saboury

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)

Abstract α-Synuclein (α-Syn) aggregates are key components of intracellular inclusion bodies characteristic of Parkinson’s disease (PD) and other synucleinopathies. Metal ions have been considered as the important etiological factors in PD since

Externí odkaz: https://doaj.org/article/41350441dded4e119e8788cf12fedb76

The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production:Highlighting its antibiotic activity

Autor: Mitra, Pirhaghi, Zahra, Najarzadeh, Faezeh, Moosavi-Movahedi, Mahshid, Shafizadeh, Fatemeh, Mamashli, Deyhim, Atarod, Atiyeh, Ghasemi, Dina, Morshedi, Ali Akbar, Meratan, Daniel E, Otzen, Ali Akbar, Saboury

Publikováno v: Pirhaghi, M, Najarzadeh, Z, Moosavi-Movahedi, F, Shafizadeh, M, Mamashli, F, Atarod, D, Ghasemi, A, Morshedi, D, Meratan, A A, Otzen, D E & Saboury, A A 2023, ' The anti-platelet drug ticlopidine inhibits FapC fibrillation and biofilm production : Highlighting its antibiotic activity ', Biochimica et Biophysica Acta-Proteins and Proteomics, vol. 1871, no. 2, 140883 . https://doi.org/10.1016/j.bbapap.2022.140883

Multidrug resistance of bacteria and persistent infections related to biofilms, as well as the low availability of new antibacterial drugs, make it urgent to develop new antibiotics. Here, we evaluate the antibacterial and anti-biofilm properties of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c783bae4f81abd4bae5ec230b48fbfc
https://pure.au.dk/portal/da/publications/the-antiplatelet-drug-ticlopidine-inhibits-fapc-fibrillation-and-biofilm-production(73eeea64-02c1-4f5a-b527-d61f3565bb38).html

Expression and Characterization of a Novel Recombinant Cytotoxin II from Naja naja oxiana Venom: A Potential Treatment for Breast Cancer

Autor: Sara Mahmoudzadeh, Khalil Haji‐Asgarzadeh, Oronzo Brunetti, Deyhim Atarod, Afshin Derakhshani, Hossein Safarpour, Nicola Silvestris, Mohammad Fereidouni, Behzad Baradaran, Angelo Paradiso

Breast cancer (BC) is among the leading causes of mortality from cancer in women. Many of the available anticancer drugs have various side effects. Therefore, researchers are seeking novel anticancer agents particularly from natural compounds and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba9eccfedff30137b723294fc3cf317b
https://doi.org/10.20944/preprints202005.0098.v1

Microtubule Dynamicity Is More Important than Stability in Memory Formation: an In Vivo Study

Autor: Gholam Hossein Riazi, Farid Pazhoohi, Deyhim Atarod, Ghazaleh Eskandari-Sedighi, Mojtaba Khajeloo, Seyed Morteza Karimian

Publikováno v: Journal of Molecular Neuroscience. 56:313-319

It has been shown that microtubule (MT) activity and dynamics can have huge impacts on synaptic plasticity and memory formation. This is mainly due to various functions of MTs in neurons; MTs are involved in dendritic spine formation, axonal transpor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db7045511351fad6f59d35ba6efe334d
https://doi.org/10.1007/s12031-015-0535-4

Static magnetic fields can diminish neuron spines through microtubule dynamicity disruption

Autor: Atiye Liaghi, Ali Naghshineh, Ali Afrasiabi, Ali Dadras, Gholam Hossein Riazi, Deyhim Atarod

Publikováno v: 2015 Sixth International Conference of Cognitive Science (ICCS).

Recently, the hypothesis in which memory and information would be stored as magnetic forms in astrocytes is expanding and neuromagnetic interactions between neurons and neighboring astrocytes in neocortex have potential to be the basis of memory form

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98e4c58309eb9f18ee4e540c1096f29d
https://doi.org/10.1109/cogsci.2015.7426664