Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Autor: Guaitoli, G., Raimondi, F., Gilsbach, B.K., Gómez-Llorente, Y., Deyaert, E., Renzi, F., Li, X., Schaffner, A., Jagtap, P.K., Boldt, K., von Zweydorf, F., Gotthardt, K., Lorimer, D.D., Yue, Z., Burgin, A., Janjic, N., Sattler, M., Versées, W., Ueffing, M., Ubarretxena-Belandia, I., Kortholt, A., Gloeckner, C.J.

Publikováno v: Proc. Natl. Acad. Sci. U.S.A. 113, E4357-E4366 (2016)

Leucine-rich repeat kinase 2 (LRRK2) is a large, multidomain protein containing two catalytic domains: a Ras of complex proteins (Roc) G-domain and a kinase domain. Mutations associated with familial and sporadic Parkinson's disease (PD) have been id

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Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Autor: Guaitoli G; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, Raimondi F; Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy; Cell Networks, University of Heidelberg, 69120 Heidelberg, Germany;, Gilsbach BK; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Department of Cell Biochemistry, University of Groningen, Groningen 9747 AG, The Netherlands; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227 Dortmund, Germany;, Gómez-Llorente Y; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Deyaert E; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Vlaams Instituut voor Biotechnologie, Structural Biology Research Center, Vrije Universiteit Brussel, 1050 Brussels, Belgium;, Renzi F; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Li X; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Schaffner A; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Jagtap PK; Center for Integrated Protein Science Munich at Department of Chemistry, Technische Universität München, 85747 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Munich, Germany;, Boldt K; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, von Zweydorf F; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, Gotthardt K; Structural Biology Group, Max Planck Institute for Molecular Physiology, 44227 Dortmund, Germany;, Lorimer DD; Beryllium Discovery Corporation, Bainbridge Island, WA 98110;, Yue Z; Departments of Neurology and Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029;, Burgin A; Broad Institute, Cambridge, MA 02142;, Janjic N; SomaLogic, Boulder, CO 80301., Sattler M; Center for Integrated Protein Science Munich at Department of Chemistry, Technische Universität München, 85747 Garching, Germany; Institute of Structural Biology, Helmholtz Zentrum München, 85764 Munich, Germany;, Versées W; Structural Biology Brussels, Vrije Universiteit Brussel, 1050 Brussels, Belgium; Vlaams Instituut voor Biotechnologie, Structural Biology Research Center, Vrije Universiteit Brussel, 1050 Brussels, Belgium;, Ueffing M; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany;, Ubarretxena-Belandia I; Department of Structural and Chemical Biology, Icahn School of Medicine at Mount Sinai, New York, NY 10029; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de., Kortholt A; Department of Cell Biochemistry, University of Groningen, Groningen 9747 AG, The Netherlands; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de., Gloeckner CJ; German Center for Neurodegenerative Diseases, 72076 Tübingen, Germany; Center for Ophthalmology, Institute for Ophthalmic Research, Eberhard Karls University, 72076 Tübingen, Germany; iban.ubarretxena@mssm.edu a.kortholt@rug.nl johannes.gloeckner@dzne.de.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Jul 26; Vol. 113 (30), pp. E4357-66. Date of Electronic Publication: 2016 Jun 29.