Safety and reactogenicity of a controlled human infection model of sand fly-transmitted cutaneous leishmaniasis.

Autor: Parkash V; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Ashwin H; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Dey S; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Sadlova J; Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic., Vojtkova B; Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic., Van Bocxlaer K; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK.; Skin Research Centre, Hull York Medical School, York, UK., Wiggins R; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Thompson D; York and Scarborough Teaching Hospitals NHS Foundation Trust, York, UK., Dey NS; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Jaffe CL; Department of Microbiology and Molecular Genetics, Kuvin Center for the Study of Infectious and Tropical Diseases, IMRIC, The Hebrew University - Hadassah Medical School, Jerusalem, Israel., Schwartz E; Center for Geographic Medicine and Tropical Diseases, Chaim Sheba Medical Center and the School of Medicine, Tel Aviv University, Tel Aviv, Israel., Volf P; Department of Parasitology, Faculty of Science, Charles University, Prague, Czech Republic., Lacey CJN; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK., Layton AM; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK. alison.layton@hyms.ac.uk.; Skin Research Centre, Hull York Medical School, York, UK. alison.layton@hyms.ac.uk., Kaye PM; York Biomedical Research Institute, Hull York Medical School, University of York, York, UK. paul.kaye@york.ac.uk.; Skin Research Centre, Hull York Medical School, York, UK. paul.kaye@york.ac.uk.

Publikováno v: Nature medicine [Nat Med] 2024 Nov; Vol. 30 (11), pp. 3150-3162. Date of Electronic Publication: 2024 Aug 02.

Immune dysregulation and inflammation causing hypopigmentation in post kala-azar dermal leishmaniasis: partners in crime?

Autor: Sengupta R; Dept. of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B AJC Bose Road, Kolkata 700020, India., Roy M; Dept. of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B AJC Bose Road, Kolkata 700020, India., Dey NS; York Biomedical Research Institute, Hull York Medical School, University of York, Heslington, York, YO10 5DD, UK., Kaye PM; York Biomedical Research Institute, Hull York Medical School, University of York, Heslington, York, YO10 5DD, UK., Chatterjee M; Dept. of Pharmacology, Institute of Post Graduate Medical Education and Research, 244B AJC Bose Road, Kolkata 700020, India. Electronic address: ilatimc@gmail.com.

Publikováno v: Trends in parasitology [Trends Parasitol] 2023 Oct; Vol. 39 (10), pp. 822-836. Date of Electronic Publication: 2023 Aug 15.

Upregulation of β-catenin due to loss of miR-139 contributes to motor neuron death in amyotrophic lateral sclerosis.

Autor: Hawkins S; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK; Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK., Namboori SC; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK; Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK., Tariq A; Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK; Biosciences, University of Exeter, Exeter EX4 4QD, UK., Blaker C; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Flaxman C; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Dey NS; York Biomedical Research Institute, Hull York Medical School, University of York, York YO10 5DD, UK., Henley P; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Randall A; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK., Rosa A; Department of Biology and Biotechnologies Charles Darwin, Sapienza University of Rome, P.le A. Moro 5, 00185 Rome, Italy; Center for Life Nano- & Neuro-Science, Fondazione Istituto Italiano di Tecnologia (IIT), 00161 Rome, Italy., Stanton LW; Qatar Biomedical Research Institute, Hamad Bin Khalifa University, Doha, Qatar., Bhinge A; College of Medicine and Health, University of Exeter, Exeter EX1 2LU, UK; Living Systems Institute, University of Exeter, Exeter EX4 4QD, UK. Electronic address: a.bhinge@exeter.ac.uk.

Publikováno v: Stem cell reports [Stem Cell Reports] 2022 Jul 12; Vol. 17 (7), pp. 1650-1665. Date of Electronic Publication: 2022 Jun 23.

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis.

Autor: Dey NS; York Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom., Senaratne S; Department of Parasitology, University of Sri Jayewardenepura, Nugegoda, Sri Lanka., Somaratne V; Dermatology Unit, District General Hospital Embilipitiya, Embilipitiya, Sri Lanka., Madarasinghe NP; Dermatology Unit, Teaching Hospital Anuradhapura, Anuradhapura, Sri Lanka., Seneviratne B; Deparment of Pathology, University of Sri Jayewardenepura, Nugegoda, Sri Lanka., Forrester S; York Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom., Montes de Oca M; York Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom., Reis LC; Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil., Moulik S; Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, India., Walrad PB; York Biomedical Research Institute, Department of Biology, University of York, York, United Kingdom., Chatterjee M; Department of Pharmacology, Institute of Postgraduate Medical Education and Research, Kolkata, India., Goto H; Instituto de Medicina Tropical de São Paulo, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.; Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil., Wickremasinghe R; Department of Parasitology, University of Sri Jayewardenepura, Nugegoda, Sri Lanka., Lagos D; York Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom., Kaye PM; York Biomedical Research Institute, Hull York Medical School, University of York, York, United Kingdom., Ranasinghe S; Department of Parasitology, University of Sri Jayewardenepura, Nugegoda, Sri Lanka.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2021 Nov 15; Vol. 131 (22).

Relish plays a dynamic role in the niche to modulate Drosophila blood progenitor homeostasis in development and infection.

Autor: Ramesh P; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, India.; Developmental Genetics Laboratory, IISER Mohali, SAS Nagar, Punjab, India., Dey NS; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, India.; Developmental Genetics Laboratory, IISER Mohali, SAS Nagar, Punjab, India., Kanwal A; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, India.; Developmental Genetics Laboratory, IISER Mohali, SAS Nagar, Punjab, India., Mandal S; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, India.; Molecular Cell and Developmental Biology Laboratory, IISER Mohali, SAS Nagar, Punjab, India., Mandal L; Department of Biological Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Knowledge City, India.; Developmental Genetics Laboratory, IISER Mohali, SAS Nagar, Punjab, India.

Publikováno v: ELife [Elife] 2021 Jul 22; Vol. 10. Date of Electronic Publication: 2021 Jul 22.