Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Dexter N, Dean"'
Autor:
Dexter N. Dean, Jennifer C. Lee
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93705d4f311d0b3441e812b0c7409c34
https://doi.org/10.1007/978-1-0716-2597-2_7
https://doi.org/10.1007/978-1-0716-2597-2_7
Autor:
Dexter N, Dean, Jennifer C, Lee
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
The premelanosomal protein (Pmel17) is a human functional amyloid that promotes pigmentation by serving as a scaffold for melanin polymerization. This occurs within the melanosome, where Pmel17 is first proteolyzed into smaller domain(s) that are res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f32937eebdb7cf550ebb4429a41e72b7
https://pubmed.ncbi.nlm.nih.gov/36310198
https://pubmed.ncbi.nlm.nih.gov/36310198
Publikováno v:
Biophysical Journal. 122:203a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dca3aa24477bb9ab9d98936a5a14a03a
https://doi.org/10.1016/j.bpj.2022.11.1226
https://doi.org/10.1016/j.bpj.2022.11.1226
pH-Dependent fibril maturation of a Pmel17 repeat domain isoform revealed by tryptophan fluorescence
Autor:
Dexter N. Dean, Jennifer C. Lee
Publikováno v:
Biochim Biophys Acta Proteins Proteom
The pre-melanosomal protein (Pmel17) aggregates within melanosomes to form functional amyloid fibrils that facilitate melanin polymerization. The repeat domain (RPT) of Pmel17 fibrillates under strict acidic melanosomal pH. Alternative splicing resul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53bbf40fe89bf5ff209f7beec7af7b93
https://doi.org/10.1016/j.bbapap.2019.01.012
https://doi.org/10.1016/j.bbapap.2019.01.012
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111492 (2014)
The aggregation of amyloid-β (Aβ) peptide and its deposition in parts of the brain form the central processes in the etiology of Alzheimer disease (AD). The low-molecular weight oligomers of Aβ aggregates (2 to 30 mers) are known to be the primary
Externí odkaz:
https://doaj.org/article/5638b39d66f740229b70655b1709b65a
Linking Parkinson’s Disease and Melanoma: Interplay between α-Synuclein and Pmel17 Amyloid Formation
Autor:
Dexter N. Dean, Jennifer C. Lee
Publikováno v:
Mov Disord
Parkinson's disease (PD) is a neurodegenerative disorder associated with the death of dopaminergic neurons within the substantia nigra of the brain. Melanoma is a cancer of melanocytes, pigmented cells that give rise to skin tone, hair, and eye color
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ac9df3e6eeabf44ad09e7091397bd7
https://europepmc.org/articles/PMC8316358/
https://europepmc.org/articles/PMC8316358/
Autor:
Dexter N. Dean, Jennifer C. Lee
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
An epidemiological connection exists between Parkinson’s disease (PD) and melanoma. α-Synuclein (α-syn), the hallmark pathological amyloid observed in PD, is also elevated in melanoma, where its expression is inversely correlated with melanin con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d368cd6ed4dc44167e01f25e84f5e678
https://pubmed.ncbi.nlm.nih.gov/32868414
https://pubmed.ncbi.nlm.nih.gov/32868414
Autor:
Sarah E. Morgan, Dexter N. Dean, Vijayaraghavan Rangachari, Shailendra Dhakal, Kristy D. Dillon, Kelli A. Stockmal, Munir F. Adamo, Yona Levites, Jhinuk Saha
Publikováno v:
FASEB J
The FASEB Journal
The FASEB Journal
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that affects cognition and memory. Recent advances have helped identify many clinical sub‐types in AD. Mounting evidence point toward structural polymorphism among fibrillar aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835ee462b4171e2ba9e66bcf3399f023
https://pubmed.ncbi.nlm.nih.gov/33508158
https://pubmed.ncbi.nlm.nih.gov/33508158
Publikováno v:
Chembiochem
Conformational changes in α-synuclein (α-syn) are central to its biological function and Parkinson's disease pathology. Here, terminal alkynes (homopropargylglycine) were employed as environmentally sensitive Raman probes at residues 1, 5, 116, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41df8c20acc1093712059431bff3b16c
https://europepmc.org/articles/PMC7269816/
https://europepmc.org/articles/PMC7269816/
Autor:
Dexter N. Dean, Jennifer C. Lee
Publikováno v:
The Journal of Biological Chemistry
The premelanosomal protein (PMEL17) forms functional amyloid fibrils involved in melanin biosynthesis. Multiple PMEL17 isoforms are produced, two of which arise from excision of a cryptic intron within the amyloid-forming repeat (RPT) domain, leading
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b4c5f2121e7125dff0dff4335e12af0
https://pubmed.ncbi.nlm.nih.gov/32277052
https://pubmed.ncbi.nlm.nih.gov/32277052