Zobrazeno 1 - 10
of 272
pro vyhledávání: '"Dexin Kong"'
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-11 (2024)
Abstract Background Although there is considerable evidence of a robust correlation between rheumatoid arthritis (RA) and carpal tunnel syndrome (CTS) in previous research, the causal link between the two remains a topic of controversy. Methods We co
Externí odkaz:
https://doaj.org/article/5cdbe14bbf684ee9b989f5422d2952a9
Autor:
Wennan Zhao, Xue Wang, Lifeng Han, Chunze Zhang, Chenxi Wang, Dexin Kong, Mingzhe Zhang, Tong Xu, Gen Li, Ge Hu, Jiahua Luo, Sook Wah Yee, Jia Yang, Andreas Stahl, Xin Chen, Youcai Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Activated Wnt/β-catenin pathway is a key genetic event in liver cancer development. Solute carrier (SLC) transporters are promising drug targets. Here, we identify SLC13A3 as a drug-targetable effector downstream of β-catenin in liver canc
Externí odkaz:
https://doaj.org/article/4c511a008a6f45259087fc1be05e3f4c
Autor:
Feifei Yang, Dexin Kong, Wenhao Liu, Dazhi Huang, Hailong Wu, Xingkai Che, Zhenyi Pan, Yongfu Li
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 284, Iss , Pp 117021- (2024)
Benzophenone-4 (BP-4), a widely utilized organic ultraviolet (UV) filter, is recognized as a pseudo-persistent contaminant in aquatic environments. To elucidate the effects and mechanisms of BP-4 on marine diatoms, an investigation was conducted on t
Externí odkaz:
https://doaj.org/article/55993867e22b4dceb579988a556e7db3
Autor:
Xin Peng, Xin Huang, Shaolu Zhang, Naixin Zhang, Shengfan Huang, Yingying Wang, Zhenxing Zhong, Shan Zhu, Haiwang Gao, Zixiang Yu, Xiaotong Yan, Zhennan Tao, Yuxiang Dai, Zhe Zhang, Xi Chen, Feng Wang, Francois X. Claret, Moshe Elkabets, Ning Ji, Yuxu Zhong, Dexin Kong
Publikováno v:
Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024)
Abstract PARP inhibitors (PARPi) hold substantial promise in treating glioblastoma (GBM). However, the adverse effects have restricted their broad application. Through unbiased transcriptomic and proteomic sequencing, it is discovered that the BET in
Externí odkaz:
https://doaj.org/article/71a393bc885744d6a1d90f1327dd6a2c
Autor:
Xin Peng, Xin Huang, Talal Ben Lulu, Wenqing Jia, Shaolu Zhang, Limor Cohen, Shengfan Huang, Jindian Fan, Xi Chen, Shanshan Liu, Yongzhe Wang, Kailin Wang, Sho Isoyama, Shingo Dan, Feng Wang, Zhe Zhang, Moshe Elkabets, Dexin Kong
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-23 (2024)
Abstract Background Phosphoinositide 3-kinases (PI3Ks) are critical regulators of diverse cellular functions and have emerged as promising targets in cancer therapy. Despite significant progress, existing PI3K inhibitors encounter various challenges
Externí odkaz:
https://doaj.org/article/8ff42a862e624392b12fa5dce4b9e982
Autor:
Dexin Kong, Yanjuan He, Jiaxin Wang, Lanyan Chi, Xiang Ao, Hejia Ye, Weihong Qiu, Xiutong Zhu, Ming Liao, Huiying Fan
Publikováno v:
Emerging Microbes and Infections, Vol 13, Iss 1 (2024)
ABSTRACTThe H5N1 subtype highly pathogenic avian influenza virus (HPAIV) reveals high variability and threatens poultry production and public health. To prevent the spread of H5N1 HPAIV, we developed an H5N1 virus-like particle (VLP) vaccine based on
Externí odkaz:
https://doaj.org/article/a2b63d3eaf4a472e99cdee6b5f31b497
Autor:
Ofra Novoplansky, Avital B. Shnerb, Divyasree Marripati, Sankar Jagadeeshan, Raghda Abu Shareb, Cristina Conde‐López, Jonathan Zorea, Manu Prasad, Talal Ben Lulu, Ksenia M. Yegodayev, Chen Benafsha, Yushi Li, Dexin Kong, Fengshen Kuo, Luc G. T. Morris, Ina Kurth, Jochen Hess, Moshe Elkabets
Publikováno v:
Molecular Oncology, Vol 17, Iss 12, Pp 2618-2636 (2023)
Blocking the mitogen‐activated protein kinase (MAPK) pathway with the MEK1/2 inhibitor trametinib has produced promising results in patients with head and neck squamous cell carcinoma (HNSCC). In the current study, we showed that trametinib treatme
Externí odkaz:
https://doaj.org/article/dfae4467864b4fe58887dab33f08a3c3
Autor:
Yan Zhang, Tingting Guo, Shurong Li, Zehao Ren, Shan Gao, Hao Lu, Xuelan Ma, Donghui Liu, Yao Liu, Dexin Kong, Yuling Qiu
Publikováno v:
Discover Oncology, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Purpose The present study aimed to explore the anticancer activity of hirsuteine (HST), an indole alkaloid from the traditional Chinese herbal medicine Uncaria rhynchophylla, against colorectal cancer (CRC) and the underlining mechanism. Met
Externí odkaz:
https://doaj.org/article/ddadb85e180c42aeb150f9a77e94465e
Autor:
Xin Peng, Yingying Wang, Shaolu Zhang, Zhennan Tao, Yuxiang Dai, Francois X. Claret, Moshe Elkabets, Hou-Wen Lin, Zhe-Sheng Chen, Dexin Kong
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/97a884f58d4847c9aeb7134160e38a14
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis. Here, we explored the anti-cance
Externí odkaz:
https://doaj.org/article/d7f9999bc82843f9a8a68e036a4517e3