Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dexin, Deng"'
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundTriple-negative breast cancer (TNBC) is proposed at the beginning of this century, which is still the most challenging breast cancer subtype due to its aggressive behavior, including early relapse, metastatic spread, and poor survival. This
Externí odkaz:
https://doaj.org/article/1826c1c035ee4d2ea8c29cabb56ff627
Autor:
Kongjun Liu, Wei Zheng, Yong Chen, Minghai Tang, Dan Li, Dexin Deng, Tao Yang, Chufeng Zhang, Jiang Liu, Xue Yuan, Mingsong Shi, Xiandeng Li, Yong Guo, Yanting Zhou, Min Zhao, Lijuan Chen
Publikováno v:
Journal of Medicinal Chemistry. 65:9893-9917
Nowadays, PI3Kδ-γ dual inhibitors have been approved for the treatment of B-cell malignancies. Dual inhibition of PI3Kδ and PI3Kγ represents a unique therapeutic opportunity and may confer greater benefits than either isoform inhibition alone in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::269879bbc679b6daec44c932658666f2
https://doi.org/10.1021/acs.jmedchem.2c00568
https://doi.org/10.1021/acs.jmedchem.2c00568
Autor:
Xiaoying Cai, Lun Wang, Yuyao Yi, Dexin Deng, Mingsong Shi, Minghai Tang, Na Li, Haoche Wei, Ruijia Zhang, Kaiyue Su, Haoyu Ye, Lijuan Chen
Publikováno v:
European Journal of Medicinal Chemistry. 256:115469
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e7af0118eb1683bd2921c16a7b6d07
https://doi.org/10.1016/j.ejmech.2023.115469
https://doi.org/10.1016/j.ejmech.2023.115469
Autor:
Jiang Liu, Xue Yuan, Kongjun Liu, Wei Zheng, Dan Li, Chufeng Zhang, Min Zhao, Lijuan Chen, Yong Chen, Dexin Deng, Mingsong Shi, Zhuang Yang, Minghai Tang, Tao Yang
Publikováno v:
Journal of Medicinal Chemistry. 64:8951-8970
Guided by molecular docking, a commonly used open-chain linker was cyclized into a five-membered pyrrolidine to lock the overall conformation of the propeller-shaped molecule. Different substituents were introduced into the pyrrolidine moiety to bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f844582af39685135c8ce636ee586be1
https://doi.org/10.1021/acs.jmedchem.1c00004
https://doi.org/10.1021/acs.jmedchem.1c00004
Autor:
Kongjun Liu, Wenyan Qi, Tao Yang, Dexin Deng, Chufeng Zhang, Lijuan Chen, Mingli Xiang, Yong Li, Yong Chen, Minghai Tang
Publikováno v:
Journal of Medicinal Chemistry. 64:1966-1988
TYK2 mediates signaling of IL-23, IL-12, and Type I IFN-driven responses that are critical in immune-mediated diseases. Herein, we report the design, synthesis, and structure-activity relationships (SARs) of 3-(4-(2-((1H-indol-5-yl)amino)-5-fluoropyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0846579be286af52902d3deec02f23
https://doi.org/10.1021/acs.jmedchem.0c01468
https://doi.org/10.1021/acs.jmedchem.0c01468
Autor:
Xue Yuan, Yong Chen, Minghai Tang, Yuhan Wei, Mingsong Shi, Yingxue Yang, Yanting Zhou, Tao Yang, Jiang Liu, Kongjun Liu, Dexin Deng, Chufeng Zhang, Lijuan Chen
Publikováno v:
Journal of medicinal chemistry. 65(13)
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) has been demonstrated to be a promising target for treating inflammatory diseases. Herein, we describe the discovery and optimization of a series of RIPK2 inhibitors derived from an FLT3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::039dedded4246379703e4a19141bd302
https://pubmed.ncbi.nlm.nih.gov/35709396
https://pubmed.ncbi.nlm.nih.gov/35709396
Autor:
Yong Guo, Yurong Zou, Yong Chen, Dexin Deng, Zihao Zhang, Kongjun Liu, Minghai Tang, Tao Yang, Suhong Fu, Chufeng Zhang, Wenting Si, Ziyan Ma, Shunjie Zhang, Bin Peng, Dingguo Xu, Lijuan Chen
Publikováno v:
Bioorganic Chemistry. 132:106386
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::481f5efbca4642e6cd57a9579b9daa89
https://doi.org/10.1016/j.bioorg.2023.106386
https://doi.org/10.1016/j.bioorg.2023.106386
Autor:
Ming Li, Yuqiang Li, Xiyun Deng, Liang Zeng, Dan Wang, Chanjuan Zheng, Dexin Deng, Kangtao Wang, Lian Xue, Fengbo Tan, Qian Pei
Background: Triple-negative breast cancer (TNBC) is a subtype of breast cancer proposed at the beginning of this century, which is still the most challenging breast cancer subtype due to its aggressive behavior, including early relapse, metastatic sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73a6f68cac8c0b34fa7b98660e3f505d
https://doi.org/10.21203/rs.3.rs-783425/v1
https://doi.org/10.21203/rs.3.rs-783425/v1
Autor:
Chufeng, Zhang, Wenyan, Qi, Yong, Li, Minghai, Tang, Tao, Yang, Kongjun, Liu, Yong, Chen, Dexin, Deng, Mingli, Xiang, Lijuan, Chen
Publikováno v:
Journal of medicinal chemistry. 64(4)
TYK2 mediates signaling of IL-23, IL-12, and Type I IFN-driven responses that are critical in immune-mediated diseases. Herein, we report the design, synthesis, and structure-activity relationships (SARs) of 3-(4-(2-((1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d77a33db514fd5134c1b831595e11717
https://pubmed.ncbi.nlm.nih.gov/33593051
https://pubmed.ncbi.nlm.nih.gov/33593051
Autor:
Yunhua Zheng, Lun Wang, Suhong Fu, Wei Zheng, Jianhong Yang, Xu Ma, Yun-Zi Luo, Minghai Tang, Lijuan Chen, Linlin Xue, Aihua Peng, Qi-Yuan Zhao, Heying Pei, Dexin Deng, Min Zhao, Ling Liu, Haoyu Ye, Kongjun Liu
Publikováno v:
European journal of medicinal chemistry. 209
Magnolol and honokiol are the two major active ingredients with similar structure and anticancer activity from traditional Chinese medicine Magnolia officinalis, and honokiol is now in a phase I clinical trial (CTR20170822) for advanced non-small cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb2e7b306b668ae4d2248a673345d43
https://pubmed.ncbi.nlm.nih.gov/33069436
https://pubmed.ncbi.nlm.nih.gov/33069436