Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Dewight R. Williams"'
Autor:
Purbasha Nandi, Shan Li, Rod Carlo A. Columbres, Feng Wang, Dewight R. Williams, Yu-Ping Poh, Tsui-Fen Chou, Po-Lin Chiu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8079 (2021)
IBMPFD/ALS is a genetic disorder caused by a single amino acid mutation on the p97 ATPase, promoting ATPase activity and cofactor dysregulation. The disease mechanism underlying p97 ATPase malfunction remains unclear. To understand how the mutation a
Externí odkaz:
https://doaj.org/article/9f08726992584fa1ba2a51f08262e895
Publikováno v:
Nucleic Acids Research. 50:7697-7720
Artemis nuclease and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) are key components in nonhomologous DNA end joining (NHEJ), the major repair mechanism for double-strand DNA breaks. Artemis activation by DNA-PKcs resolves hairpin DNA en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3430439c762a634fedbf0bbe5eaabff3
https://doi.org/10.1093/nar/gkac564
https://doi.org/10.1093/nar/gkac564
Autor:
Mohammed S Aiyegbo, Gopal Sapparapu, Benjamin W Spiller, Ilyas M Eli, Dewight R Williams, Robert Kim, David E Lee, Tong Liu, Sheng Li, Virgil L Woods, David P Nannemann, Jens Meiler, Phoebe L Stewart, James E Crowe
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61101 (2013)
Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent human B cell response is directed to the internal protein VP6 on the surface of double-layere
Externí odkaz:
https://doaj.org/article/d90e29a9134149ab94b8e00efa12fec7
Autor:
Rekha Pattanayek, Dewight R Williams, Gian Rossi, Steven Weigand, Tetsuya Mori, Carl H Johnson, Phoebe L Stewart, Martin Egli
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23697 (2011)
The circadian clock in the cyanobacterium Synechococcus elongatus is composed of a post-translational oscillator (PTO) that can be reconstituted in vitro from three different proteins in the presence of ATP and a transcription-translation feedback lo
Externí odkaz:
https://doaj.org/article/883f5c0e779149c99a9900b96e6d7e17
Publikováno v:
The Journal of biological chemistry. 292(45)
p97 is an essential ATPase associated with various cellular activities (AAA+) that functions as a segregase in diverse cellular processes, including the maintenance of proteostasis. p97 interacts with different cofactors that target it to distinct pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8de2e7e6314c31c0444e9d27e6b4c462
https://pubmed.ncbi.nlm.nih.gov/28939772
https://pubmed.ncbi.nlm.nih.gov/28939772
Publikováno v:
Structure. 16(3):468-477
The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) regulates the nonhomologous end joining pathway for repair of double-stranded DNA (dsDNA) breaks. Here, we present a 7A resolution structure of DNA-PKcs determined by cryo-electron microsc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::115eec8494028a808d11e1c6ec9bcab0
Publikováno v:
Eukaryotic Cell. 1:758-773
The fission yeast minichromosome loss mutant mcl1-1 was identified in a screen for mutants defective in chromosome segregation. Missegregation of the chromosomes in mcl1-1 mutant cells results from decreased centromeric cohesion between sister chroma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027c6d9bec970b6aa48ac7e36c252935
https://doi.org/10.1128/ec.1.5.758-773.2002
https://doi.org/10.1128/ec.1.5.758-773.2002
Publikováno v:
Biochemistry. 34:6278-6287
A photosensing protein directs light energy captured by its chromophore into a photocycle. The protein's structure must accommodate the photocycle and promote the resulting chemical or conformational changes that lead to signal transduction. The 1.4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e1f29e12265867d8fe0441e79e6dae
https://doi.org/10.1021/bi00019a004
https://doi.org/10.1021/bi00019a004
Publikováno v:
Journal of structural biology. 164(1)
High throughput methods of data acquisition are advantageous for cryoelectron microscopy and single particle reconstruction as high-resolution structure determination requires thousands of particle images. We have developed a semi-automated data coll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c76eda30f110cb8d742e57a117cb2a
https://pubmed.ncbi.nlm.nih.gov/18621546
https://pubmed.ncbi.nlm.nih.gov/18621546
Autor:
J. R. McIntosh, Dewight R. Williams
Publikováno v:
Eukaryotic cell. 4(1)
Mcl1p is an essential fission yeast chromatin-binding protein that belongs to a family of highly conserved eukaryotic proteins important for sister chromatid cohesion. The essential function is believed to result from its role as a Pol1p (polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58b67d08f11762996e8f6ad7c7f1316
https://pubmed.ncbi.nlm.nih.gov/15643072
https://pubmed.ncbi.nlm.nih.gov/15643072