Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Dewen You"'
Autor:
Dewen You, Junping Xin, Andrew Volk, Wei Wei, Rachel Schmidt, Gina Scurti, Sucha Nand, Eun-Kyoung Breuer, Paul C. Kuo, Peter Breslin, Ameet R. Kini, Michael I. Nishimura, Nancy J. Zeleznik-Le, Jiwang Zhang
Publikováno v:
Cell Reports, Vol 10, Iss 12, Pp 2055-2068 (2015)
Mutations and inactivation of phosphatase and tensin homolog deleted from chromosome 10 (PTEN) are observed in 15%–25% of cases of human T cell acute lymphoblastic leukemia (T-ALL). Pten deletion induces myeloproliferative disorders (MPDs), acute m
Externí odkaz:
https://doaj.org/article/fbbe6516a419435696ed1b95c74a3386
Autor:
Yipeng Wang, Zhiye Zhang, Lingling Chen, Huijuan Guang, Zheng Li, Hailong Yang, Jianxu Li, Dewen You, Haining Yu, Ren Lai
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22120 (2011)
Cathelicidins are a family of antimicrobial peptides acting as multifunctional effector molecules in innate immunity. Cathelicidin-BF has been purified from the snake venoms of Bungarus fasciatus and it is the first identified cathelicidin antimicrob
Externí odkaz:
https://doaj.org/article/7a7493650ad849cf801bff5c92a5f0d2
Autor:
Alvin H. Schmaier, Dana E. Angelini, Ravi Kumar Alluri, John Barnard, Suman Kundu, Keith R. McCrae, Edward P. Feener, Samantha A. Whitney, Victor Chatterjee, Alok A. Khorana, Young Jun Shim, Dewen You, Shadi Swaidani, Alona Merkulova
Publikováno v:
Blood Advances
Key Points Cleaved HK is observed in many patients with cancer, suggesting activation of the contact system.EVs from cancer cell lines or patients with cancer express polyphosphate, bind and activate FXII, and are prothrombotic.
Visual Abstract<
Visual Abstract<
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20370bd70436fc1df9423e0e59c0c7fe
http://europepmc.org/articles/PMC8759128
http://europepmc.org/articles/PMC8759128
Autor:
Andrew Volk, Peter Breslin, Yechen Xiao, Wei Wei, Jianke Zhang, Zhou Zhang, Jianjun Chen, Dewen You, Xingyu Li, Xinli Liu, Rachel Schmidt, Jun Zhang, Jiwang Zhang, Paul C. Kuo, Junping Xin, Jing Li, Sucha Nand, Zejuan Li
Publikováno v:
The Journal of Experimental Medicine
TNF signaling inactivation sensitizes AML cells to NF-kB inhibition but protects healthy hematopoietic stem progenitor cells from this treatment.
Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive t
Leukemic stem cells (LSCs) isolated from acute myeloid leukemia (AML) patients are more sensitive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6e33b00be07d9b6e67626776a1cedd
https://doi.org/10.1084/jem.20130990
https://doi.org/10.1084/jem.20130990
Autor:
Cassandra M Kerr, Xiaorong Gu, Ryszard Olinski, Daniel Gackowski, Guangbo Qu, Dewen You, Babal K. Jha, Bartlomiej P Przychodzen, Amy C Graham, Edward F Greenberg, Feng Pan, Hassan Awada, Ashwin Kishtagari, Jibran Durrani, Valeria Visconte, Mikkael A. Sekeres, Jaroslaw P. Maciejewski, Yihong Guan, Mingjiang Xu, Yu-Wei Cheng, Hideki Makishima, Thomas LaFramboise
Publikováno v:
Blood. 134:1200-1200
TET2 mutations (TET2MT) occur around 40% of myeloid neoplasms (MN) and often constitute founder hits, as concluded from patient's clonal architecture and subclinical TET2MT clones in healthy individuals at risk for MN. The mechanisms of TET2MT in leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3a92e7110bbe76fd5f48da1cb863d9f
https://doi.org/10.1182/blood-2019-132005
https://doi.org/10.1182/blood-2019-132005
Autor:
Peter Breslin, Jiang Zhu, Dewen You, Wei Wei, Jing Li, J Pan, Andrew Volk, Allen Ni, M M Patel, Z Xia, Rachel Schmidt, Joseph Cannova, Grace Ng, Rafael Gutierrez, Jiwang Zhang, Sucha Nand, Paul C. Kuo, Jianjun Chen, Ameet R. Kini, Junping Xin, Haiyan Chen, Y Xiao
Publikováno v:
Leukemia. 31(5)
Tumor necrosis factor-α (TNF-α)-induced RIP1/RIP3 (receptor-interacting protein kinase 1/receptor-interacting protein kinase 3)-mediated necroptosis has been proposed as an alternative strategy for treating apoptosis-resistant leukemia. However, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0cb377933ead9ab394bdf35082d8aa6c
https://pubmed.ncbi.nlm.nih.gov/27748372
https://pubmed.ncbi.nlm.nih.gov/27748372
Publikováno v:
Journal of Proteome Research. 10:4230-4240
Tree frogs produce a variety of skin defensive chemicals against many biotic and abiotic risk factors for their everyday survival. By proteomics or peptidomics and coupling transcriptome analysis with pharmacological testings, 27 peptides or proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4ec06fe557d6499fe02a45603c97429
https://doi.org/10.1021/pr200393t
https://doi.org/10.1021/pr200393t
Autor:
Lixian Mu, Dewen You, Lin Wei, Jianxu Li, Keyun Zhang, Ming Chen, Rui Liu, Ren Lai, Huan Liu, Tianhua Yan
Publikováno v:
Journal of Peptide Science. 17:627-631
Two antimicrobial peptides (piceain 1 and 2) derived from sequences encoded Picea sitchensis are identified. Their amino acid sequences are KSLRPRCWIKIKFRCKSLKF and RPRCWIKIKFRCKSLKF, respectively. One intra-molecular disulfide bridge is formed by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8be58b2d750cc4d0588bfa67c73fe5
https://doi.org/10.1002/psc.1380
https://doi.org/10.1002/psc.1380
Autor:
Hideki Makishima, Yihong Guan, Shi Chen, Mingjiang Xu, Mridul Mukherji, Mikkael A. Sekeres, Bartlomiej P Przychodzen, Eiju Negoro, Edward F Greenberg, Jaroslaw P. Maciejewski, Metis Hasipek, Amy C Graham, Babal K. Jha, Tomas Radivoyevitch, Daniel Gackowski, Xiaochen Liu, Cassandra M. Hirsch, Dewen You, Ryszard Olinski, Aziz Nazha, Ewelina Zarakowska, Valeria Visconte
Publikováno v:
Blood. 132:4346-4346
Loss-of-function TET2 mutations (TET2mt) strongly associate with myeloid neoplasia. TET2 is an α-ketoglutarate (αKG) and Fe2+-dependent DNA-dioxygenase that hydroxylates 5-methylcytosine-DNA (5mC), producing 5-hydroxymethylcytosine-DNA (5hmC). Asco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::52d9a28c4f0e05cb74d2510534c54341
https://doi.org/10.1182/blood-2018-99-119712
https://doi.org/10.1182/blood-2018-99-119712
Publikováno v:
Blood. 132:3800-3800
Introduction Cancer-associated thrombosis (CAT) affects up to 20% of patients with cancer, and causes substantial morbidity and mortality. Although tissue factor has been most studied, several other mechanisms contribute to the development of CAT. Re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::554ec25613b0f45b4a5c2ec38efff3dd
https://doi.org/10.1182/blood-2018-99-117308
https://doi.org/10.1182/blood-2018-99-117308