Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Dewar J. Tan"'
Autor:
Catherine A. Sabatos-Peyton, James Nevin, Ansgar Brock, John D. Venable, Dewar J. Tan, Nasim Kassam, Fangmin Xu, John Taraszka, Luke Wesemann, Thomas Pertel, Nandini Acharya, Max Klapholz, Yassaman Etminan, Xiaomo Jiang, Yu-Hwa Huang, Richard S. Blumberg, Vijay K. Kuchroo, Ana C. Anderson
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Both in vivo data in preclinical cancer models and in vitro data with T cells from patients with advanced cancer support a role for Tim-3 blockade in promoting effective anti-tumor immunity. Consequently, there is considerable interest in the clinica
Externí odkaz:
https://doaj.org/article/3c144a1874ea4d4292b8f6ab85913507
Publikováno v:
Journal of Autoimmunity. 59:38-42
Genetic variants in il2 and il2ra have been associated with autoimmune disease susceptibility in both genome-wide association studies (GWAS) in humans and in genetic linkage studies in experimental models of autoimmunity. Specifically, genetic varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe8570954e9ce9feed2cf63692dcaff5
https://doi.org/10.1016/j.jaut.2015.02.001
https://doi.org/10.1016/j.jaut.2015.02.001
Autor:
Qingming Hou, Amit Prasad, Hongbo R. Luo, Hakryul Jo, Heng-Ye Man, Kumaran Shanmugasundaram, Alan C. Rigby, Eiichiro Nagata, Shunya Takizawa, Joe K. Tung, Alok K. Sharma, Dewar J. Tan, Subhanjan Mondal, Alexander O. Tejeda
Publikováno v:
Proceedings of the National Academy of Sciences. 109:10581-10586
Elevating Akt activation is an obvious clinical strategy to prevent progressive neuronal death in neurological diseases. However, this endeavor has been hindered because of the lack of specific Akt activators. Here, from a cell-based high-throughput
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6219f298318631989a217a5e44e990e9
https://doi.org/10.1073/pnas.1202810109
https://doi.org/10.1073/pnas.1202810109
Autor:
Hyun-Tak Jin, Chen Zhu, Rafi Ahmed, Vijay K. Kuchroo, Chuan Wu, Thomas Pertel, Zhiyi Sun, Ana C. Anderson, Sheng Xiao, Manu Rangachari, Chao Wang, Dewar J. Tan, Kaori Sakuishi, Guangxiang Gu, Sarah Zaghouani
Publikováno v:
Nature Communications. 6
Corrigendum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL–10 expression and T-cell dysfunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ec9ae9a714746ec6d601f9ba9ea96c1
https://doi.org/10.1038/ncomms8657
https://doi.org/10.1038/ncomms8657
Autor:
Sema Kurtulus, Ana C. Anderson, Shin Foong Ngiow, Kaori Sakuishi, Vijay K. Kuchroo, Nicole Joller, Michele W.L. Teng, Dewar J. Tan, Mark J. Smyth
Publikováno v:
The Journal of clinical investigation. 125(11)
Coinhibitory receptors are critical for the maintenance of immune homeostasis. Upregulation of these receptors on effector T cells terminates T cell responses, while their expression on Tregs promotes their suppressor function. Understanding the func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83584a8f3e1cd48022e02e310dba7e4
https://pubmed.ncbi.nlm.nih.gov/26413872
https://pubmed.ncbi.nlm.nih.gov/26413872
Autor:
Fangmin Xu, Ansgar Brock, Vijay K. Kuchroo, Luke Wesemann, Dewar J. Tan, Max Klapholz, James Nevin, Xiaomo Jiang, Catherine Anne Sabatos-Peyton, Richard S. Blumberg, John D. Venable, Nasim Kassam, Nandini Acharya, Thomas Pertel, Yu-Hwa Huang, Ana C. Anderson, Yassaman Etminan, John A. Taraszka
Publikováno v:
OncoImmunology, Vol 7, Iss 2 (2018)
Both in vivo data in preclinical cancer models and in vitro data with T cells from patients with advanced cancer support a role for Tim-3 blockade in promoting effective anti-tumor immunity. Consequently, there is considerable interest in the clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa867917120436c999facf865a2123e
https://doi.org/10.1080/2162402x.2017.1385690
https://doi.org/10.1080/2162402x.2017.1385690
Autor:
Vijay K. Kuchroo, Hyun-Tak Jin, Rafi Ahmed, Manu Rangachari, Ana C. Anderson, Chen Zhu, Chuan Wu, Kaori Sakuishi, Thomas Pertel, Zhiyi Sun, Chao Wang, Dewar J. Tan, Guangxiang Gu, Sheng Xiao, Sarah Zaghouani
Publikováno v:
Nature communications
The inhibitory receptor T-cell immunoglobulin and mucin domain-3 (Tim-3) has emerged as a critical regulator of the T-cell dysfunction that develops in chronic viral infections and cancers. However, little is known regarding the signalling pathways t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de4600c72106ae6257998fbbac22a04
http://europepmc.org/articles/PMC4311884
http://europepmc.org/articles/PMC4311884
Autor:
Kaori Sakuishi, Dewar J. Tan, Ana C. Anderson, Mark J. Smyth, Vijay K. Kuchroo, Nicole Joller, Sema Kurtulus, Huiyuan Zhang
Publikováno v:
Journal for Immunotherapy of Cancer
Meeting abstracts TIGIT is a co-inhibitory molecule that limits T cell proliferation and activation. TIGIT expression has been recently shown to identify a subset of regulatory T cells (Treg) that specifically suppresses Th1 and Th17 responses; howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f58898523b3a1ea9bb78b6d72ec6d5e