Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Dewan Zeng"'
Autor:
John Wu, Andrew G. Hill, Michael Millward, Catherine Barrow, Christopher Jackson, Michael P. Brown, William F. Patterson, Wendy Huang, Zhiyu Tang, Victoria Atkinson, Gary Richardson, Hui K Gan, Ben Tran, Yunxin Chen, Dewan Zeng, Lisa G. Horvath, Lusong Luo, Andrew Haydon, Michael B. Jameson, Lai Wang, Ben Markman, Jayesh Desai, Stephen Begbie, Phillip Parente, Adnan Nagrial, Benjamin Solomon, Michael Friedlander
Publikováno v:
Journal of Clinical Oncology
PURPOSE Lifirafenib is an investigational, reversible inhibitor of B-RAFV600E, wild-type A-RAF, B-RAF, C-RAF, and EGFR. This first-in-human, phase I, dose-escalation/dose-expansion study evaluated the safety, tolerability, and efficacy of lifirafenib
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9224 (2010)
BACKGROUND:Adenosine is generated in response to cellular stress and damage and is elevated in the lungs of patients with chronic lung disease. Adenosine signaling through its cell surface receptors serves as an amplifier of chronic lung disorders, s
Externí odkaz:
https://doaj.org/article/b489a5d855bc4d1fa6210b8c64d26e6a
Autor:
Luiz Belardinelli, Dewan Zeng, Rodolfo Bonatti, Richard L. Verrier, Bruce D. Nearing, Julio A. P. Batatinha, Ana Flavia Garcia Silva
Publikováno v:
Journal of Cardiovascular Pharmacology. 69:178-182
Introduction We examined the effects of the selective late INa inhibitor eleclazine on the 50% probability of successful defibrillation (DFT50) before and after administration of amiodarone to determine its suitability for use in patients with implan
Autor:
Bruce D. Nearing, F G B S Ana Silva, A P B S Julio Batatinha, Gongxin Liu, Luiz Belardinelli, Richard L. Verrier, B S Rodolfo Bonatti, Sridharan Rajamani, Dewan Zeng
Publikováno v:
Journal of Cardiovascular Electrophysiology. 26:329-335
Drug Combination Reduces Ventricular Rate in AFIntroduction Ventricular rate during atrial fibrillation (AF) can be reduced by slowing atrioventricular (AV) node conduction and/or by decreasing dominant frequency of AF. We investigated whether combin
Autor:
D B S Ananda Machado, Bruno B. Varone, Richard L. Verrier, Dewan Zeng, Bruce D. Nearing, F B S Lucas Sobrado, Luiz Belardinelli
Publikováno v:
Journal of Cardiovascular Electrophysiology. 24:914-918
Dronedarone's Bradycardic Effect Introduction The mechanism(s) whereby dronedarone reduces sinus rate are not well understood, although L-type calcium channel antagonism, beta-adrenergic blockade, and inhibition of If are plausible. Methods and Resul
Autor:
Ewa Karwatowska-Prokopczuk, Luiz Belardinelli, Whedy Wang, Dewan Zeng, Peter J. Schwartz, Mei L Cheng
Publikováno v:
EP Europace. 15:429-436
Aims Clinical utility of QTc prolongation as a predictor for sudden cardiac death (SCD) has not been definitely established. Ranolazine causes modest QTc prolongation, yet it shows antiarrhythmic properties. We aimed to determine the association betw
Autor:
Eleonora Mezzaroma, Luiz Belardinelli, Dewan Zeng, Antonio Abbate, Harsha Kannan, Stefano Toldo, Hongyan Zhong, Benjamin W. Van Tassell, Norbert F. Voelkel
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 343:587-595
Adenosine (Ado) is released in response to tissue injury, promotes hyperemia, and modulates inflammation. The proinflammatory effects of Ado, which are mediated by the A(2B) Ado receptor (AdoR), may exacerbate tissue damage. We hypothesized that sele
Autor:
Joshua D. Lovelock, Hong Liu, Euy Myoung Jeong, Dewan Zeng, Praveen Kumar, Samuel C. Dudley, Luiz Belardinelli, Domenico M. Taglieri, R. John Solaro, Michelle M. Monasky, Bindiya G. Patel, Narayan Pokhrel, Harvey A. Lardin, Lianzhi Gu, Dan Sorescu
Publikováno v:
Circulation Research. 110:841-850
Rationale: Previously, we demonstrated that a deoxycorticosterone acetate (DOCA)-salt hypertensive mouse model produces cardiac oxidative stress and diastolic dysfunction with preserved systolic function. Oxidative stress has been shown to increase l
Autor:
Xiaobin Xu, Erin Walsh, E. J. Messina, Yuzhi Wu, Stephen P. Baker, Thomas H. Hintze, John C. Shryock, Gong Zhao, Luiz Belardinelli, Dewan Zeng, Manuel Ochoa
Publikováno v:
Journal of Cardiovascular Pharmacology. 57:639-647
Effects of ranolazine alone and in the presence of phenylephrine (PE) or isoproterenol (ISO) on hemodynamics, coronary blood flow and heart rate (HR) in the absence and presence of hexamethonium (a ganglionic blocker) were studied in conscious dogs.
Publikováno v:
Journal of Clinical Oncology. 36:TPS3113-TPS3113
TPS3113Background: Programmed cell death-1 (PD-1) and its ligand, programmed death-ligand 1 (PD-L1), play critical roles in the immune modulation of tumor progression. Tislelizumab is a humanized I...