Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Devrishi, Goswami"'
Autor:
James E. Longbotham, Cynthia M. Chio, Venkatasubramanian Dharmarajan, Michael J. Trnka, Idelisse Ortiz Torres, Devrishi Goswami, Karen Ruiz, Alma L. Burlingame, Patrick R. Griffin, Danica Galonić Fujimori
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The demethylase activity of KDM5A is allosterically enhanced by binding of histone H3 to its PHD1 reader domain, through an unknown mechanism. Here the authors show that the PHD1 domain drives ligand-induced allosteric stimulation by stabilizing the
Externí odkaz:
https://doaj.org/article/8af366d414d64557aaf7cda67d5a31e7
Autor:
Patrick R. Griffin, Alma L. Burlingame, Karen Ruiz, James E. Longbotham, Michael J. Trnka, Venkatasubramanian Dharmarajan, Danica Galonić Fujimori, Devrishi Goswami, Cynthia M. Chio, Idelisse Ortiz Torres
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Histone demethylase KDM5A removes methyl marks from lysine 4 of histone H3 and is often overexpressed in cancer. The in vitro demethylase activity of KDM5A is allosterically enhanced by binding of its product, unmodified H3 peptides, to its PHD1 read
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa07a528279d37d374d938247f4ad58
https://doaj.org/article/8af366d414d64557aaf7cda67d5a31e7
https://doaj.org/article/8af366d414d64557aaf7cda67d5a31e7
Publikováno v:
Methods. 144:134-151
Mass spectrometry (MS)-based methods for analyzing protein higher order structures have gained increasing application in the field of biopharmaceutical development. The predominant methods used in this area include native MS, hydrogen deuterium excha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88aee8cb0defcb1021d9d411f1c5728f
https://doi.org/10.1016/j.ymeth.2018.04.011
https://doi.org/10.1016/j.ymeth.2018.04.011
Autor:
Nicholas T. Seyfried, Serena M. Dudek, John R. Hepler, Eric B. Dammer, Devrishi Goswami, Duc M. Duong, Jenny J. Yang, Kyle J. Gerber, Paul R. Evans, Daniel Lustberg, Juan Zou, Patrick R. Griffin
Publikováno v:
Journal of Proteome Research. 17:1700-1711
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::461c694334f519624abf1c2c3bd7c56f
https://doi.org/10.1021/acs.jproteome.8b00027
https://doi.org/10.1021/acs.jproteome.8b00027
Autor:
Bruce D. Pascal, Eric A. Ortlund, Emily R. Weikum, Scott J. Novick, Richard A. Kahn, Patrick R. Griffin, Joshua W. Francis, Devrishi Goswami
Publikováno v:
Journal of Molecular Biology. 429:3696-3716
Microtubules are highly dynamic tubulin polymers that are required for a variety of cellular functions. Despite the importance of a cellular population of tubulin dimers, we have incomplete information about the mechanisms involved in the biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2d7c7480d8b23bdd25992e7a172f7b
https://doi.org/10.1016/j.jmb.2017.09.016
https://doi.org/10.1016/j.jmb.2017.09.016
Autor:
Karsten Melcher, Kuntal Pal, Devrishi Goswami, Gongpu Zhao, H. Eric Xu, Yanting Yin, Xiang Gao, Li Hou, Oliver P. Ernst, Patrick R. Griffin, Yuanzheng He
Publikováno v:
Cell Research
G protein-coupled receptor kinases (GRKs) play pivotal roles in desensitizing GPCR signaling but little is known about how GRKs recognize and phosphorylate GPCRs due to the technical difficulties in detecting the highly dynamic GPCR/GRK interaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea724adcab07770454e33cc7041eb895
https://doi.org/10.1038/cr.2017.72
https://doi.org/10.1038/cr.2017.72
Autor:
Nathan T. Jui, Jozef Stec, Autumn R. Flynn, Devrishi Goswami, Patrick R. Griffin, C. Denise Okafor, Michael C. Dugan, Richard J. Whitby, Suzanne G. Mays, Eric A. Ortlund
Publikováno v:
Journal of Biological Chemistry. 291:25281-25291
Liver receptor homolog 1 (NR5A2, LRH-1) is an orphan nuclear hormone receptor that regulates diverse biological processes, including metabolism, proliferation, and the resolution of endoplasmic reticulum stress. Although preclinical and cellular stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2126458f02beb5390b195ebfe57efec6
https://doi.org/10.1074/jbc.m116.753541
https://doi.org/10.1074/jbc.m116.753541
Autor:
Manuel Molina-Martin, Juan F. Espinosa, Patrick R. Griffin, David J. Cummins, Alfonso Espada, Devrishi Goswami, Howard B. Broughton, Ryan Edward Stites, Bruce D. Pascal, Michael J. Chalmers, Jeffrey Alan Dodge, Scott J. Novick
Publikováno v:
Analytical Chemistry. 88:6607-6614
Hydrogen/deuterium exchange coupled with mass spectrometry (HDX-MS) is an information-rich biophysical method for the characterization of protein dynamics. Successful applications of differential HDX-MS include the characterization of protein-ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f4811489bad786b8766bf5b85c872c
https://doi.org/10.1021/acs.analchem.6b01650
https://doi.org/10.1021/acs.analchem.6b01650
Autor:
Paul R, Evans, Kyle J, Gerber, Eric B, Dammer, Duc M, Duong, Devrishi, Goswami, Daniel J, Lustberg, Juan, Zou, Jenny J, Yang, Serena M, Dudek, Patrick R, Griffin, Nicholas T, Seyfried, John R, Hepler
Publikováno v:
Journal of proteome research. 17(4)
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein that integrates G protein and MAPK signaling pathways. In the adult mouse brain, RGS14 is predominantly expressed in hippocampal CA2 neurons where it naturally inhibits syna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d574bf7b8e75f0603d112d06047cbd27
https://pubmed.ncbi.nlm.nih.gov/29518331
https://pubmed.ncbi.nlm.nih.gov/29518331
Autor:
John R. Hepler, Nicholas T. Seyfried, Daniel Lustberg, Patrick R. Griffin, Jenny J. Yang, Juan Zou, Paul R. Evans, Kyle J. Gerber, Serena M. Dudek, Eric B. Dammer, Duc M. Duong, Devrishi Goswami
Regulator of G Protein Signaling 14 (RGS14) is a complex scaffolding protein with an unusual domain structure that allows it to integrate G protein and mitogen-activated protein kinase (MAPK) signaling pathways. RGS14 mRNA and protein are enriched in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8395bb6eb6ab4fc3754aca3a52a47501
https://doi.org/10.1101/247270
https://doi.org/10.1101/247270
