Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Devon S. Svoboda"'
Autor:
Xin Tang, Gary LeRoy, Alicia V. Zamudio, Alessandra Dall’Agnese, Richard A. Young, Emile Wogram, Jurian Schuijers, Nancy M. Hannett, Jonathan E. Henninger, Tenzin Lungjangwa, Tong Ihn Lee, Jesse M. Platt, Eliot L. Coffey, Ozgur Oksuz, X. Shawn Liu, Styliani Markoulaki, Charles H. Li, Lena K. Afeyan, Rudolf Jaenisch, Devon S. Svoboda
Publikováno v:
Nature
Methyl CpG binding protein 2 (MeCP2) is a key component of constitutive heterochromatin, which is crucial for chromosome maintenance and transcriptional silencing1–3. Mutations in the MECP2 gene cause the progressive neurodevelopmental disorder Ret
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f51fc72bdd6c60ff1b8c95fcbf6cd08
https://doi.org/10.1038/s41586-020-2574-4
https://doi.org/10.1038/s41586-020-2574-4
Autor:
Devon S. Svoboda, Peter Berube, Maya Mitalipova, Shupei Zhang, Rudolf Jaenisch, M. Inmaculada Barrasa, Rosalie G. J. Rietjens, Dongdong Fu, Jian Shu, Leonard D. Shultz, George W. Bell
Publikováno v:
Proc Natl Acad Sci U S A
Microglia are essential for maintenance of normal brain function, with dysregulation contributing to numerous neurological diseases. Protocols have been developed to derive microglia-like cells from human induced pluripotent stem cells (hiPSCs). Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ae280fb5e5e3cfd51231ccd5f256c9
https://europepmc.org/articles/PMC6911218/
https://europepmc.org/articles/PMC6911218/
Autor:
Ruth S. Slack, Jason G. MacLaurin, Devon S. Svoboda, David S. Park, Diane C. Lagace, Mireille Khacho, Alysen Clark
Mitochondrial dysfunction is a common feature of many genetic disorders that target the brain and cognition. However, the exact role these organelles play in the etiology of such disorders is not understood. Here, we show that mitochondrial dysfuncti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e16165878d08f189f164c8a4a451cee
https://europepmc.org/articles/PMC5886206/
https://europepmc.org/articles/PMC5886206/
Autor:
Yves De Repentigny, Rashmi Kothary, Noël Ghanem, Alexandre Blais, Kelly A. McClellan, Lisa M. Julian, Matthew G. Andrusiak, Sawsan M. Al Lafi, Marc Ekker, Ruth S. Slack, Devon S. Svoboda, David S. Park
Publikováno v:
Journal of Neuroscience. 32:8219-8230
During brain morphogenesis, the mechanisms through which the cell cycle machinery integrates with differentiation signals remain elusive. Here we show that the Rb/E2F pathway regulates key aspects of differentiation and migration through direct contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741ad2591545e512ff2fd010edcbb855
https://doi.org/10.1523/jneurosci.1344-12.2012
https://doi.org/10.1523/jneurosci.1344-12.2012
Autor:
Michael D. Kawaja, Devon S. Svoboda
Publikováno v:
Journal of Proteomics. 75:1752-1763
Hypertension is a systemic disorder affecting numerous physiological processes throughout the body. As non-alcoholic fatty liver disorder (NAFLD) is a common comorbidity of hypertension in humans, we hypothesized that molecular hepatic physiology wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e4bf038e796f7f9ce23ad57b06c42d
https://doi.org/10.1016/j.jprot.2011.12.011
https://doi.org/10.1016/j.jprot.2011.12.011
Autor:
Ruth S. Slack, Devon S. Svoboda, David S. Park, Alysen Clark, Mireille Khacho, Hiromi Sesaki, Jason G. MacLaurin, Joelle Azzi, Cynthia Meghaizel, Diane C. Lagace, Mary-Ellen Harper, Marc Germain
Publikováno v:
Cell stem cell. 19(2)
Regulated mechanisms of stem cell maintenance are key to preventing stem cell depletion and aging. While mitochondrial morphology plays a fundamental role in tissue development and homeostasis, its role in stem cells remains unknown. Here, we uncover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e018c3b45533811f60d971c6421969d
https://pubmed.ncbi.nlm.nih.gov/27237737
https://pubmed.ncbi.nlm.nih.gov/27237737
Publikováno v:
Journal of visualized experiments : JoVE. (95)
Genetic deletion using the Cre-Lox system in transgenic mouse lines is a powerful tool used to study protein function. However, except in very specific Cre models, deletion of a protein throughout a tissue or cell population often leads to complex ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c06a3d31d1da7cf6b505629e15dae69
https://pubmed.ncbi.nlm.nih.gov/25650557
https://pubmed.ncbi.nlm.nih.gov/25650557
Publikováno v:
Journal of Visualized Experiments.
Genetic deletion using the Cre-Lox system in transgenic mouse lines is a powerful tool used to study protein function. However, except in very specific Cre models, deletion of a protein throughout a tissue or cell population often leads to complex ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995d969defd358c922214754752a2c13
https://doi.org/10.3791/51983
https://doi.org/10.3791/51983
Autor:
Philip A. Barker, Stefano Stifani, Hosam Al-Jehani, Devon S. Svoboda, Laurent Methot, Ruth S. Slack, Sumit Jhas, Robert Hermann, Yeman Tang, Rita Lo
Publikováno v:
Molecular and cellular biology. 33(14)
The involvement of nuclear factor kappa B (NF-κB) in several processes in the postnatal and adult brain, ranging from neuronal survival to synaptogenesis and plasticity, has been documented. In contrast, little is known about the functions of NF-κB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa701d456f916485e85557bbe4961a76
https://pubmed.ncbi.nlm.nih.gov/23689134
https://pubmed.ncbi.nlm.nih.gov/23689134
Publikováno v:
International Journal of Developmental Neuroscience. 47:92-92
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714c1cf8827a59eb6c54094b2c98c347
https://doi.org/10.1016/j.ijdevneu.2015.04.252
https://doi.org/10.1016/j.ijdevneu.2015.04.252