Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Devon L Moose"'
Autor:
Courtney Yong, Devon L Moose, Nadine Bannick, Wade R Gutierrez, Marion Vanneste, Robert Svensson, Patrick Breheny, James A Brown, Rebecca D Dodd, Michael B Cohen, Michael D Henry
Publikováno v:
PLoS ONE, Vol 15, Iss 9, p e0232807 (2020)
Here we have improved an existing mouse model of prostate cancer based on prostate-specific deletion of Pten and Trp53 by incorporating a Cre-activatable luciferase reporter. By coupling the deletion of those genes to the activation of a luciferase r
Externí odkaz:
https://doaj.org/article/ce7d1f3ddce84cf390873022563396c7
Autor:
Marisa R Buchakjian, Nicole M Merritt, Devon L Moose, Adam J Dupuy, Munir R Tanas, Michael D Henry
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183469 (2017)
Genetic mouse models of soft tissue sarcoma provide critical insights into disease pathophysiology, which are oftentimes unable to be extracted from human tumor samples or xenograft models. In this study we describe a mouse model of soft tissue sarco
Externí odkaz:
https://doaj.org/article/110cec91e0cb46afa5b7de457cbbbd2d
Autor:
Melissa A. Marchal, Devon L. Moose, Afshin Varzavand, Nicole E. Jordan, Destiney Taylor, Munir R. Tanas, James A. Brown, Michael D. Henry, Christopher S. Stipp
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionAbl family kinases function as proto-oncogenes in various leukemias, and pro-tumor functions have been discovered for Abl kinases in many solid tumors as well. However, a growing body of evidence indicates that Abl kinases can function to
Externí odkaz:
https://doaj.org/article/3f74f3b22e7d4202910ff27fb642931d
Autor:
Devon L. Moose, Michael D. Henry
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 4 (2020)
During metastasis, cancer cells traverse the circulation to reach distant organs. Conventionally, this journey has been regarded as mechanically destructive to circulating tumor cells from solid tissues. We have recently shown that cancer cells from
Externí odkaz:
https://doaj.org/article/f99e319b7a3149868123ebd8bb48fe05
Autor:
Han Chen, Sommer Y. Osman, Devon L. Moose, Marion Vanneste, Jared L. Anderson, Michael D. Henry, Robbyn K. Anand
Publikováno v:
Lab on a Chip.
Dielectrophoretic capture of circulating melanoma cell (CMC) and white blood cells (WBCs) is quantified as a function of electric field frequency, and the optimized conditions are utilized to isolate CMCs from patient-derived blood samples.
Autor:
Devon L. Moose, Amanda N. Pope, Marion Vanneste, Patrick Breheny, Eric B. Taylor, Michael D. Henry
Publikováno v:
Cancer Research. 83:B047-B047
Background and Purpose: Circulating tumor cells (CTCs) are exposed to mechanical and biochemical stresses including fluid shear stress (FSS), due to blood flow, and oxidative distress, from a lack of matrix attachment. Recently we have shown that via
Publikováno v:
Journal of Visualized Experiments.
During metastasis, cancer cells from solid tissues, including epithelia, gain access to the lymphatic and hematogenous circulation where they are exposed to mechanical stress due to hemodynamic flow. One of these stresses that circulating tumor cells
Autor:
Devon L. Moose, Qin Huang, Michael K. Schultz, Meng Wu, Lei Zhao, Michael D. Henry, Marion Vanneste, Mark Stamnes, Mengshi Li
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Epithelial-to-mesenchymal transition (EMT) is implicated in cancer metastasis and drug resistance. Specifically targeting cancer cells in an EMT-like state may have therapeutic value. In this study, we developed a cell imaging-based high-content scre
Autor:
Andrew M. Bellizzi, Shaikamjad Umesalma, Gideon K. D. Zamba, Michael D. Henry, Patrick Breheny, Chandra K. Maharjan, Sarah L. Mott, Courtney A. Kaemmer, Goutham Narla, Benjamin W. Darbro, Devon L. Moose, Dawn E. Quelle
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Pancreatic neuroendocrine neoplasms (pNENs) are slow growing cancers of increasing incidence that lack effective treatments once they become metastatic. Unfortunately, nearly half of pNEN patients present with metastatic liver tumors at diagnosis and
Autor:
Brianne R. O'Leary, Juan Du, Devon L. Moose, Matthew S. Alexander, Joseph J. Cullen, Michael D. Henry
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Pharmacological ascorbate (P-AscH−, high-dose, intravenous vitamin C) is cytotoxic to tumor cells in doses achievable in humans. Phase I studies in pancreatic cancer (PDAC) utilizing P-AscH− have demonstrated increases in progression free surviva