Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Devon Jeltema"'
Autor:
Xintao Tu, Ting-Ting Chu, Devon Jeltema, Kennady Abbott, Kun Yang, Cong Xing, Jie Han, Nicole Dobbs, Nan Yan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Microbial DNA is recognized by the cGAS-STING pathway, which leads to a type I interferon response. Here authors show that a basal flux of interferon activation could also be triggered by interference with STING trafficking from the Golgi apparatus t
Externí odkaz:
https://doaj.org/article/2f9d65377a264c70b9738aa78c4ec3c2
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 13, p 3328 (2019)
The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant ac
Externí odkaz:
https://doaj.org/article/87e19faab2044c80ae8b33e5104b5f74
Publikováno v:
J Immunol
The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a critical component of the innate immune system that is activated by microbial infections and cellular stress signals. The molecular mechanism of NLRP3 inflammasome activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d07b4ee0609d9bd1d50e781dd891c0a
https://doi.org/10.4049/jimmunol.2101154
https://doi.org/10.4049/jimmunol.2101154
Publikováno v:
Journal of Experimental Medicine. 220
The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical for microbial defense. Unlike other innate immune pathways that largely rely on stationary cascades of signaling events, STING is highly mobile in the cell. STI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c03556eb9cb422aeb094acbaebe84f1
https://doi.org/10.1084/jem.20220990
https://doi.org/10.1084/jem.20220990
Publikováno v:
The Journal of Immunology. 208:52.02-52.02
The NLRP3 inflammasome is a critical component of the innate immune system that is activated by microbial infections and cellular stress signals. The molecular mechanism of NLRP3 inflammasome activation remains not fully understood. As an NLRP3-inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ddde54a4c5ee97084626e5241c23ba89
https://doi.org/10.4049/jimmunol.208.supp.52.02
https://doi.org/10.4049/jimmunol.208.supp.52.02