Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Devon Hominick"'
Autor:
Devon Hominick, Asitha Silva, Noor Khurana, Ying Liu, Paul C Dechow, Jian Q Feng, Bronislaw Pytowski, Joseph M Rutkowski, Kari Alitalo, Michael T Dellinger
Publikováno v:
eLife, Vol 7 (2018)
Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress VEGF-C in bone exhibit a phenotype that resembles GSD. To drive VEGF-C expression in bone,
Externí odkaz:
https://doaj.org/article/4c9afa6ab7224a18ac1cce0629d75378
Autor:
Elena Vallespín, Gloria Oliva-Molina, Ana Bustamante, Victor Martinez-Glez, Michael T. Dellinger, Isabel Colmenero, Rebeca Rodríguez Pena, Kristina Ibáñez, Carmen Ayuso, Cristina Villaverde, Noelia Agra, Rubén Martín-Arenas, Devon Hominick, Noor Khurana, Lara Rodriguez-Laguna, Pablo Lapunzina, María J. Beato, Juan Carlos López-Gutiérrez, Angela del Pozo, Gema Gordo, Gonzalo Herranz, Juan M. Torres Canizalez
Publikováno v:
Journal of Experimental Medicine. 216:407-418
Generalized lymphatic anomaly (GLA) is a vascular disorder characterized by diffuse or multifocal lymphatic malformations (LMs). The etiology of GLA is poorly understood. We identified four distinct somatic PIK3CA variants (Glu542Lys, Gln546Lys, His1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94f598cddd6cb5a6a3b7b7bb97372c89
https://doi.org/10.1084/jem.20181353
https://doi.org/10.1084/jem.20181353
Publikováno v:
Development
Bones do not normally have lymphatics. However, patients with generalized lymphatic anomaly (GLA) or Gorham-Stout disease (GSD) develop ectopic lymphatics in bone. Despite growing interest in the development of tissue-specific lymphatics, the cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e80efeac0cbde228ba3c805a82d3a34f
https://pubmed.ncbi.nlm.nih.gov/32188632
https://pubmed.ncbi.nlm.nih.gov/32188632
Autor:
Pavel Yanev, Kielen R Zuurbier, Noor Khurana, Katherine Poinsatte, Marcus Berndt, Michael T. Dellinger, Ann M. Stowe, Devon Hominick, Erik J. Plautz
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
The discovery of meningeal lymphatic vessels (LVs) has sparked interest in identifying their role in diseases of the central nervous system. Similar to peripheral LVs, meningeal LVs depend on vascular endothelial growth factor receptor-3 (VEGFR3) sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf6b7dc631d5279fc1989163b8f6772
https://pubmed.ncbi.nlm.nih.gov/30621519
https://pubmed.ncbi.nlm.nih.gov/30621519
Autor:
Lara, Rodriguez-Laguna, Noelia, Agra, Kristina, Ibañez, Gloria, Oliva-Molina, Gema, Gordo, Noor, Khurana, Devon, Hominick, María, Beato, Isabel, Colmenero, Gonzalo, Herranz, Juan M, Torres Canizalez, Rebeca, Rodríguez Pena, Elena, Vallespín, Rubén, Martín-Arenas, Ángela, Del Pozo, Cristina, Villaverde, Ana, Bustamante, Carmen, Ayuso, Pablo, Lapunzina, Juan C, Lopez-Gutierrez, Michael T, Dellinger, Victor, Martinez-Glez
Publikováno v:
The Journal of Experimental Medicine
Generalized lymphatic anomaly (GLA) is a vascular disorder characterized by diffuse or multifocal lymphatic malformations (LMs). Here, Rodriguez-Laguna et al. report that somatic activating PIK3CA mutations can cause GLA, and we provide preclinical a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eebdb58195098c0d3268744e5876ca64
https://pubmed.ncbi.nlm.nih.gov/30591517
https://pubmed.ncbi.nlm.nih.gov/30591517
Autor:
Joseph M. Rutkowski, Asitha Silva, Michael T. Dellinger, Paul C. Dechow, Devon Hominick, Bronislaw Pytowski, Kari Alitalo, Jian Q. Feng, Ying Liu, Noor Khurana
Publikováno v:
eLife
eLife, Vol 7 (2018)
eLife, Vol 7 (2018)
Patients with Gorham-Stout disease (GSD) have lymphatic vessels in their bones and their bones gradually disappear. Here, we report that mice that overexpress VEGF-C in bone exhibit a phenotype that resembles GSD. To drive VEGF-C expression in bone,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b891ae347af3e00e2842a45624af2110
https://doi.org/10.7554/elife.34323
https://doi.org/10.7554/elife.34323
Autor:
Noor Khurana, Paul C. Dechow, Ying Liu, Devon Hominick, Bronislaw Pytowski, Kari Alitalo, Joseph M. Rutkowski, Jian Q. Feng, Asitha Silva, Michael T. Dellinger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb0ee1315bc42f164f7697566ab22093
https://doi.org/10.7554/elife.34323.019
https://doi.org/10.7554/elife.34323.019
