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A sulphated glycosaminoglycan extract from Placopecten magellanicus inhibits the Alzheimer's disease β-site amyloid precursor protein cleaving enzyme 1 (BACE-1).

Autor: Mycroft-West CJ; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: courtney.mycroft-west@rfi.ac.uk., Devlin AJ; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy. Electronic address: anthony.devlin@rfi.ac.uk., Cooper LC; University of Gloucestershire, Francis Close Hall Campus, Swindon Rd, Cheltenham, GL50 4AZ, UK. Electronic address: lcooper1@glos.ac.uk., Guimond SE; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: s.e.guimond@keele.ac.uk., Procter P; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: p.procter@keele.ac.uk., Miller GJ; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: g.j.miller@keele.ac.uk., Guerrini M; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133, Milan, Italy. Electronic address: guerrini@ronzoni.it., Fernig DG; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. Electronic address: dgfernig@liverpool.ac.uk., Yates EA; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. Electronic address: E.A.Yates@liverpool.ac.uk., Lima MA; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK. Electronic address: m.andrade.de.lima@keele.ac.uk., Skidmore MA; Centre for Glycoscience Research and Training, Keele University, Keele, Staffordshire, ST5 5BG, UK; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. Electronic address: m.a.skidmore@keele.ac.uk.

Publikováno v: Carbohydrate research [Carbohydr Res] 2023 Mar; Vol. 525, pp. 108747. Date of Electronic Publication: 2023 Jan 26.

Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease β Secretase, BACE1.

Autor: Mycroft-West CJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Devlin AJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Cooper LC; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Guimond SE; School of Medicine, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Procter P; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Guerrini M; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, via G. Colombo 81, 20133 Milan, Italy., Miller GJ; School of Chemistry, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Fernig DG; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK., Yates EA; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK., Lima MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK., Skidmore MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK.; Department of Biochemistry and Systems Biology, ISMIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.

Publikováno v: Marine drugs [Mar Drugs] 2021 Apr 03; Vol. 19 (4). Date of Electronic Publication: 2021 Apr 03.

A Glycosaminoglycan Extract from Portunus pelagicus Inhibits BACE1, the β Secretase Implicated in Alzheimer's Disease.

Autor: Mycroft-West CJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. c.j.mycroft-west@keele.ac.uk., Cooper LC; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. l.c.cooper@keele.ac.uk., Devlin AJ; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. a.devlin1@keele.ac.uk.; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133 Milan, Italy. a.devlin1@keele.ac.uk., Procter P; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. p.procter@keele.ac.uk., Guimond SE; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. s.e.guimond@keele.ac.uk.; Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire ST5 5BG, UK. s.e.guimond@keele.ac.uk., Guerrini M; Istituto di Ricerche Chimiche e Biochimiche G. Ronzoni, Via G. Colombo 81, 20133 Milan, Italy. guerrini@ronzoni.it., Fernig DG; School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. dgfernig@liverpool.ac.uk., Lima MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. mlimagb@gmail.com., Yates EA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. E.A.Yates@liverpool.ac.uk.; School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. E.A.Yates@liverpool.ac.uk., Skidmore MA; Molecular & Structural Biosciences, School of Life Sciences, Keele University, Huxley Building, Keele, Staffordshire ST5 5BG, UK. m.a.skidmore@keele.ac.uk.; Institute for Science and Technology in Medicine, Keele University, Keele, Staffordshire ST5 5BG, UK. m.a.skidmore@keele.ac.uk.; School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK. m.a.skidmore@keele.ac.uk.

Publikováno v: Marine drugs [Mar Drugs] 2019 May 16; Vol. 17 (5). Date of Electronic Publication: 2019 May 16.

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