Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Devkee M. Vadukul"'
A single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
Autor:
Alessandra Bigi, Liliana Napolitano, Devkee M. Vadukul, Fabrizio Chiti, Cristina Cecchi, Francesco A. Aprile, Roberta Cascella
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-19 (2024)
Abstract Background Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are considered the major neurotoxic agents in Alzheimer’s disease (AD). Cerebral lesions in the
Externí odkaz:
https://doaj.org/article/e31cb433d4c24d6992d739c228d88a50
Autor:
Federica Raguseo, Yiran Wang, Jessica Li, Marija Petrić Howe, Rubika Balendra, Anouk Huyghebaert, Devkee M. Vadukul, Diana A. Tanase, Thomas E. Maher, Layla Malouf, Roger Rubio-Sánchez, Francesco A. Aprile, Yuval Elani, Rickie Patani, Lorenzo Di Michele, Marco Di Antonio
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD. The most common genetic cause of ALS/FTD is expansion of the intronic hex
Externí odkaz:
https://doaj.org/article/7acb7c2915fa45d693187ddf1818d97f
Autor:
Nuria Suelves, Shirine Saleki, Tasha Ibrahim, Debora Palomares, Sebastiaan Moonen, Marta J. Koper, Céline Vrancx, Devkee M. Vadukul, Nicolas Papadopoulos, Nikenza Viceconte, Eloïse Claude, Rik Vandenberghe, Christine A. F. von Arnim, Stefan N. Constantinescu, Dietmar Rudolf Thal, Anabelle Decottignies, Pascal Kienlen-Campard
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-26 (2023)
Abstract Aging is the main risk factor for Alzheimer’s disease (AD) and other neurodegenerative pathologies, but the molecular and cellular changes underlying pathological aging of the nervous system are poorly understood. AD pathology seems to cor
Externí odkaz:
https://doaj.org/article/5f4fdaf58fee4378a6e15e3c44d2238d
Autor:
Devkee M. Vadukul, Céline Vrancx, Pierre Burguet, Sabrina Contino, Nuria Suelves, Louise C. Serpell, Loïc Quinton, Pascal Kienlen-Campard
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract A key hallmark of Alzheimer’s disease is the extracellular deposition of amyloid plaques composed primarily of the amyloidogenic amyloid-β (Aβ) peptide. The Aβ peptide is a product of sequential cleavage of the Amyloid Precursor Protein
Externí odkaz:
https://doaj.org/article/cffde72cfd7a458c9a29c038453f9d37
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
α-Synuclein is a key protein of the nervous system, which regulates the release and recycling of neurotransmitters in the synapses. It is also involved in several neurodegenerative conditions, including Parkinson’s disease and Multiple System Atro
Externí odkaz:
https://doaj.org/article/c4b919db269444c5b2c2cdcfba9c5ff9
Autor:
Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Céline Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard
Publikováno v:
Biomedicines, Vol 10, Iss 11, p 2753 (2022)
Most neurodegenerative diseases have the characteristics of protein folding disorders, i.e., they cause lesions to appear in vulnerable regions of the nervous system, corresponding to protein aggregates that progressively spread through the neuronal
Externí odkaz:
https://doaj.org/article/0eaccee654984de88c7b6d0588f1e379
Autor:
Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102057- (2021)
Externí odkaz:
https://doaj.org/article/f665fef4c70b4f3dab58560ad815f4ab
Autor:
Sabrina Contino, Nuria Suelves, Céline Vrancx, Devkee M. Vadukul, Valery L. Payen, Serena Stanga, Luc Bertrand, Pascal Kienlen-Campard
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2021)
Presenilin 1 (PS1) and Presenilin 2 (PS2) are predominantly known as the catalytic subunits of the γ-secretase complex that generates the amyloid-β (Aβ) peptide, the major constituent of the senile plaques found in the brain of Alzheimer's disease
Externí odkaz:
https://doaj.org/article/b607f326c9de489090109092167bf221
Autor:
Florian Perrin, Nicolas Papadopoulos, Nuria Suelves, Rémi Opsomer, Devkee M. Vadukul, Céline Vrancx, Steven O. Smith, Didier Vertommen, Pascal Kienlen-Campard, Stefan N. Constantinescu
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101887- (2020)
Summary: Amyloid precursor protein (APP) cleavage by the β-secretase produces the C99 transmembrane (TM) protein, which contains three dimerization-inducing Gly-x-x-x-Gly motifs. We demonstrate that dimeric C99 TM orientations regulate the precise c
Externí odkaz:
https://doaj.org/article/0dd44fb254d34538a6340aed44bc05be
Autor:
Juan García-Revilla, Antonio Boza-Serrano, Yiyun Jin, Devkee M. Vadukul, Jesús Soldán-Hidalgo, Lluís Camprubí-Ferrer, Marta García-Cruzado, Isak Martinsson, Oxana Klementieva, Rocío Ruiz, Francesco A. Aprile, Tomas Deierborg, José Luis Venero
Publikováno v:
Acta Neuropathologica.
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (SN). Aggregated α-synuclein (αSYN) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aad9b3c3024c3cef723776a28efe0d
https://doi.org/10.1007/s00401-023-02585-x
https://doi.org/10.1007/s00401-023-02585-x