Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Deviprasad R, Gollapalli"'
Autor:
Deviprasad R. Gollapalli, Gregory D. Cuny, Adhar C. Manna, Natalia Maltseva, Barry B. Snider, Yubo Zhang, Mohana Rao Vippila, Ann P. Lawson, Lizbeth Hedstrom, Minjia Zhang, Youngchang Kim, David M Rothstein, Shibin Chacko, Petr Kuzmic, Xingyou Wang, Andrzej Joachimiak, Ryan T Cullinane, Gyan Modi, Gary M Marqus, Ambrose L. Cheung, Judy L.M. Kotler
Publikováno v:
ACS Infectious Diseases. 7:3062-3076
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5'-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67a38314a14bd8ed48fa872a866f2505
https://doi.org/10.1021/acsinfecdis.1c00342
https://doi.org/10.1021/acsinfecdis.1c00342
Autor:
Michael J, Pepi, Shibin, Chacko, Gary M, Marqus, Vinayak, Singh, Zhe, Wang, Kyle, Planck, Ryan T, Cullinane, Penchala N, Meka, Deviprasad R, Gollapalli, Thomas R, Ioerger, Kyu Y, Rhee, Gregory D, Cuny, Helena I M, Boshoff, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
New drugs and new targets are urgently needed to treat tuberculosis. We discovered the D-phenylalanine-benzoxazole Q112 displays potent antibacterial activity against Mycobacterium tuberculosis (Mtb) in multiple media and in macrophage infections. Me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::31a1ae83ee43ca779a5028edd621871f
https://pubmed.ncbi.nlm.nih.gov/35015509
https://pubmed.ncbi.nlm.nih.gov/35015509
Autor:
Michael J. Pepi, Shibin Chacko, Gary M. Marqus, Vinayak Singh, Zhe Wang, Kyle Planck, Ryan T. Cullinane, Penchala N. Meka, Deviprasad R. Gollapalli, Thomas R. Ioerger, Kyu Y. Rhee, Gregory D. Cuny, Helena I.M. Boshoff, Lizbeth Hedstrom
This is the accepted manuscript version of the work published in its final form as Pepi, M. J., Chacko, S., Marqus, G. M., Singh, V., Wang, Z., Planck, K., Cullinane, R. T., Meka, P. N., Gollapalli, D. R., Ioerger, T. R., Rhee, K. Y., Cuny, G. D., Bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19ab59662d39e9e443744b09196020de
Autor:
Gyan, Modi, Gary M, Marqus, Mohana Rao, Vippila, Deviprasad R, Gollapalli, Youngchang, Kim, Adhar C, Manna, Shibin, Chacko, Natalia, Maltseva, Xingyou, Wang, Ryan T, Cullinane, Yubo, Zhang, Judy L M, Kotler, Petr, Kuzmic, Minjia, Zhang, Ann P, Lawson, Andrzej, Joachimiak, Ambrose, Cheung, Barry B, Snider, David M, Rothstein, Gregory D, Cuny, Lizbeth, Hedstrom
Publikováno v:
ACS Infect Dis
Many bacterial pathogens, including Staphylococcus aureus, require inosine 5’-monophosphate dehydrogenase (IMPDH) for infection, making this enzyme a promising new target for antibiotics. Although potent selective inhibitors of bacterial IMPDHs hav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ad78a428808eb670c119d890ec480eb
https://pubmed.ncbi.nlm.nih.gov/34590817
https://pubmed.ncbi.nlm.nih.gov/34590817
Autor:
Deviprasad R. Gollapalli, Erik Butcher, Siwei Cai, Daisy Shu, Ilakya Senthilkumar, Scott R. Frank, Magali Saint-Geniez
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::687193e06908d75976ea6675e7bdc064
https://doi.org/10.1096/fasebj.2021.35.s1.03272
https://doi.org/10.1096/fasebj.2021.35.s1.03272
Autor:
Shibin Chacko, Helena I. M. Boshoff, Vinayak Singh, Davide M. Ferraris, Deviprasad R. Gollapalli, Minjia Zhang, Ann P. Lawson, Michael J. Pepi, Andrzej Joachimiak, Menico Rizzi, Valerie Mizrahi, Gregory D. Cuny, Lizbeth Hedstrom
Publikováno v:
Journal of Medicinal Chemistry. 64:18233-18234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aca9679d608b3b2df3453a0e6410e709
https://doi.org/10.1021/acs.jmedchem.1c01923
https://doi.org/10.1021/acs.jmedchem.1c01923
Autor:
Lizbeth Hedstrom, Davide M. Ferraris, Shibin Chacko, Michael J. Pepi, Minjia Zhang, Helena I. Boshoff, Deviprasad R. Gollapalli, Vinayak Singh, Valerie Mizrahi, Gregory D. Cuny, Andrzej Joachimiak, Ann P. Lawson, Menico Rizzi
Publikováno v:
Journal of Medicinal Chemistry. 61:4739-4756
New drugs and molecular targets are urgently needed to address the emergence and spread of drug-resistant tuberculosis. Mycobacterium tuberculosis ( Mtb) inosine 5'-monophosphate dehydrogenase 2 ( MtbIMPDH2) is a promising yet controversial potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e74d2091981d050618d946a8dcd9ec
https://doi.org/10.1021/acs.jmedchem.7b01839
https://doi.org/10.1021/acs.jmedchem.7b01839
Autor:
Lisa Sharling, Xiaoping Liu, Deviprasad R Gollapalli, Sushil K Maurya, Lizbeth Hedstrom, Boris Striepen
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e794 (2010)
The protozoan parasite Cryptosporidium parvum is responsible for significant disease burden among children in developing countries. In addition Cryptosporidiosis can result in chronic and life-threatening enteritis in AIDS patients, and the currently
Externí odkaz:
https://doaj.org/article/c82cebf4ac364fa59487e8aa18574021
Autor:
Suresh Kumar Gorla, Youngchang Kim, Lizbeth Hedstrom, Natalia Maltseva, Minyi Gu, Kavitha Mandapati, Andrzej Joachimiak, Deviprasad R. Gollapalli, Minjia Zhang, Magdalena Makowska-Grzyska, Jerzy Osipiuk
Publikováno v:
The Journal of Biological Chemistry
Background: IMP dehydrogenase (IMPDH) is an important drug target because of its role in de novo purine nucleotide biosynthesis. Results: First substrate/cofactor- and substrate/inhibitor-bound complexes of bacterial IMPDHs are determined. Conclusion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a58b4db84d1d771deea27339f8ddec25
http://europepmc.org/articles/PMC4342496
http://europepmc.org/articles/PMC4342496
Autor:
Elizabeth S. McKenney, Suraj Nagendra Rao, Deviprasad R. Gollapalli, Ian J. Glomski, Lizbeth Hedstrom, Joanna B. Goldberg, Kavitha Mandapati, Amanda L. House, Gregory D. Cuny, Barbara J. Mann, Minjia Zhang, Suresh Kumar Gorla
Publikováno v:
ACS Medicinal Chemistry Letters. 5:846-850
Inosine 5'-monophosphate dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis. IMPDH is a target for immunosuppressive, antiviral, and anticancer drugs, but, as of yet, has not been exploited for antimicrobial therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8269b3bd144c8685b5f82b740b2bdcbb
https://doi.org/10.1021/ml500203p
https://doi.org/10.1021/ml500203p