Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Devina Purmessur"'
Autor:
Kyle Kuchynsky, Patrick Stevens, Amy Hite, William Xie, Khady Diop, Shirley Tang, Maciej Pietrzak, Safdar Khan, Benjamin Walter, Devina Purmessur
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-21 (2024)
Abstract Background Low back pain is a leading cause of disability worldwide and is frequently attributed to intervertebral disc (IVD) degeneration. Though the contributions of the adjacent cartilage endplates (CEP) to IVD degeneration are well docum
Externí odkaz:
https://doaj.org/article/11869d36df6b46af9c2a10c65a489475
Autor:
Mary K. Heimann, Kelly Thompson, Gilian Gunsch, Shirley N. Tang, Brett Klamer, Kara Corps, Benjamin A. Walter, Sarah A. Moore, Devina Purmessur
Publikováno v:
JOR Spine, Vol 7, Iss 2, Pp n/a-n/a (2024)
Abstract Background Intervertebral disk (IVD) degeneration affects both humans and canines and is a major cause of low back pain (LBP). Mast cell (MC) and macrophage (MØ) infiltration has been identified in the pathogenesis of IVD degeneration (IVDD
Externí odkaz:
https://doaj.org/article/8f4ec05be6824304a2fd1fc7e5d78291
Autor:
Dyah Agustini, Mary K. Heimann, Megan Co, Benjamin A. Walter, Devina Purmessur, Sarah A. Moore
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
IntroductionModic changes (MC) are signs of vertebral pathology visible on magnetic resonance (MR) images that have been associated with low back pain (LBP) and disc degeneration in people. Multiple breeds of dogs also develop MCs and coincident back
Externí odkaz:
https://doaj.org/article/68ba7da081cd4d538aacb3333763e31c
Autor:
Shirley Tang, Connor Gantt, Ana Salazar Puerta, Lucy Bodine, Safdar Khan, Natalia Higuita‐Castro, Devina Purmessur
Publikováno v:
JOR Spine, Vol 6, Iss 3, Pp n/a-n/a (2023)
Abstract Background Intervertebral disc (IVD) degeneration is a major contributor to low back pain (LBP), yet there are no clinical therapies targeting the underlying pathology. The annulus fibrosus (AF) plays a critical role in maintaining IVD struc
Externí odkaz:
https://doaj.org/article/a532401a9acf4b21a58fde18ecdffcf7
Autor:
Shirley N. Tang, Andres F. Bonilla, Nadeen O. Chahine, Aimee C. Colbath, Jeremiah T. Easley, Sibylle Grad, Lisbet Haglund, Christine L. Le Maitre, Victor Leung, Annette M. McCoy, Devina Purmessur, Simon Y. Tang, Stephan Zeiter, Lachlan J. Smith
Publikováno v:
JOR Spine, Vol 5, Iss 4, Pp n/a-n/a (2022)
Abstract Intervertebral disc degeneration is a common cause of low back pain, the leading cause of disability worldwide. Appropriate preclinical models for intervertebral disc research are essential to achieving a better understanding of underlying p
Externí odkaz:
https://doaj.org/article/47d3efca53e94c10a07faeab4dca43fe
Publikováno v:
JOR Spine, Vol 5, Iss 2, Pp n/a-n/a (2022)
Abstract Background Daily physiologic loading causes fluctuations in hydration of the intervertebral disc (IVD); thus, the embedded cells experience cyclic alterations to their osmotic environment. These osmotic fluctuations have been described as a
Externí odkaz:
https://doaj.org/article/8323b99d882b4c38bb477eeae539867a
Autor:
Shirley N. Tang, Benjamin A. Walter, Mary K. Heimann, Connor C. Gantt, Safdar N. Khan, Olga N. Kokiko-Cochran, Candice C. Askwith, Devina Purmessur
Publikováno v:
Frontiers in Pain Research, Vol 3 (2022)
Low back pain is a leading cause of disability worldwide and studies have demonstrated intervertebral disc (IVD) degeneration as a major risk factor. While many in vitro models have been developed and used to study IVD pathophysiology and therapeutic
Externí odkaz:
https://doaj.org/article/9b03894cc3ae4334a9b6cef983997b6c
Autor:
Benjamin Gantenbein, Shirley Tang, Julien Guerrero, Natalia Higuita-Castro, Ana I. Salazar-Puerta, Andreas S. Croft, Amiq Gazdhar, Devina Purmessur
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Viral carrier transport efficiency of gene delivery is high, depending on the type of vector. However, viral delivery poses significant safety concerns such as inefficient/unpredictable reprogramming outcomes, genomic integration, as well as unwarran
Externí odkaz:
https://doaj.org/article/e902c5b542c64969957d0b7169391459
Autor:
Justin Richards, Shirley Tang, Gilian Gunsch, Pavel Sul, Matthew Wiet, David C. Flanigan, Safdar N. Khan, Sarah Moore, Benjamin Walter, Devina Purmessur
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Mast cells (MCs) are present in the painful degenerate human intervertebral disc (IVD) and are associated with disease pathogenesis. MCs release granules containing enzymatic and inflammatory factors in response to stimulants or allergens. The serine
Externí odkaz:
https://doaj.org/article/3945c55b6e254122b2bcc845ae128cef
Publikováno v:
JOR Spine, Vol 1, Iss 1, Pp n/a-n/a (2018)
Low back pain (LBP) is the leading cause of disability worldwide, with an estimated 80% of the American population suffering from a painful back condition at some point during their lives. The most common cause of LBP is intervertebral disc (IVD) deg
Externí odkaz:
https://doaj.org/article/b6659fcb56464e6a864c1dc728635480