Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Devin Tesar"'
Autor:
Elizabeth Sara Hecht, Shrenik Mehta, Aaron T. Wecksler, Ben Aguilar, Nathaniel Swanson, Wilson Phung, Ananya Dubey Kelsoe, W. Henry Benner, Devin Tesar, Robert F. Kelley, Wendy Sandoval, Alavattam Sreedhara
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Detection of host cell protein (HCP) impurities is critical to ensuring that recombinant drug products, including monoclonal antibodies (mAbs), are safe. Mechanistic characterization as to how HCPs persist in drug products is important to refining do
Externí odkaz:
https://doaj.org/article/d0847215cccc4d5da45d73cb8db4ce8f
Autor:
Weiru Wang, Guoying Jiang, Robert F. Kelley, Devin Tesar, John Eschelbach, Xuan Gao, Bingchuan Wei
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1652-1660
Identification of critical quality attributes (CQAs) is an important step for development of biopharmaceuticals with intended performance. An accurate CQA assessment is needed to ensure product quality and focusing on development efforts where contro
Autor:
Susan Crowell, Nardos Tassew, Roxanne Andaya, Robert F. Kelley, Mandy Kwong, Kelly M. Loyet, Steven T Laing, Aija Kusi, Yue Wang, Julia Gray, Devin Tesar
Publikováno v:
Toxicologic Pathology. 49:634-646
Fusion of biologic therapeutics to hyaluronic acid binding proteins, such as the link domain (LD) of Tumor necrosis factor (TNF)-Stimulated Gene-6 (TSG-6), is expected to increase vitreous residence time following intravitreal injection and provide f
Publikováno v:
Drug Discovery Today. 24:1440-1445
Long-acting delivery (LAD) of ocular therapeutics has potential to improve the standard of care for ocular diseases, such as age-related macular degeneration (AMD), by increasing patient compliance and reducing overall treatment burden on patients an
Autor:
Juan Jenny Li, Yuwen Linda Lin, Saileta Prabhu, Kevin Lin, Suzie J. Scales, Gizette Sperinde, Shan Chung, Kathi Williams, Saloumeh K Fischer, James A. Ernst, Kai Zheng, An Song, Siddharth Sukumaran, Julien Lafrance-Vanasse, Van Nguyen, Devin Tesar, Rong Deng, Greg A. Lazar
Publikováno v:
mAbs. 11:942-955
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis...
Autor:
Devin Tesar, Jacob Luoma, Kelly M. Loyet, Robert F. Kelley, Leslie J. Dickmann, Catherine Shi, Li Yi, Jacob E. Corn, Philip E. Hass, Menno van Lookeren Campagne, Nisana Andersen, Michelle Z. Dion, Katie F. Maass, Emily A. Wyatt, Whitney Shatz, Karthikan Rajagopal, Justin Scheer, Kathryn Wang, Mary Mathieu
Publikováno v:
mAbs
To date, ocular antibody therapies for the treatment of retinal diseases rely on injection of the drug into the vitreous chamber of the eye. Given the burden for patients undergoing this procedure, less frequent dosing through the use of long-acting
Autor:
Shan, Chung, Van, Nguyen, Yuwen Linda, Lin, Julien, Lafrance-Vanasse, Suzie J, Scales, Kevin, Lin, Rong, Deng, Kathi, Williams, Gizette, Sperinde, Juan Jenny, Li, Kai, Zheng, Siddharth, Sukumaran, Devin, Tesar, James A, Ernst, Saloumeh, Fischer, Greg A, Lazar, Saileta, Prabhu, An, Song
Publikováno v:
mAbs
A cell-based assay employing Madin–Darby canine kidney cells stably expressing human neonatal Fc receptor (FcRn) heavy chain and β2-microglobulin genes was developed to measure transcytosis of monoclonal antibodies (mAbs) under conditions relevant
Autor:
Yonglei Shang, Sean B. Joseph, Konnie Urban, Saloumeh K Fischer, Saileta Prabhu, Vikas K. Sharma, Jane L. Grogan, Eugene Y. Chiang, Robert F. Kelley, Charles Andrew Boswell, Yong Ying, Isidro Hötzel, Leslie A. Khawli, Devin Tesar, Sheila Ulufatu, Daniela Bumbaca Yadav
Publikováno v:
Journal of Biological Chemistry. 290:29732-29741
The pharmacokinetic (PK) behavior of monoclonal antibodies in cynomolgus monkeys (cynos) is generally translatable to that in humans. Unfortunately, about 39% of the antibodies evaluated for PKs in cynos have fast nonspecific (or non-target-mediated)
Autor:
Yanan Zheng, Jihong Yang, Nicholas Lewin-Koh, Oliver Boris Stauch, Jane Ruppel, Sami McVay, Wendy S. Putnam, Leslie A. Khawli, Paul J. Fielder, Lisa J. Benincosa, C. Andrew Boswell, Kyra J. Cowan, Jing Li, Frank-Peter Theil, Jennifer O’Mahony, Wolfgang F. Richter, Herbert Birnböck, Hans Peter Grimm, Ann L. Daugherty, Thomas Singer, Daniela Bumbaca, Michael Pantze, Dimitry M. Danilenko, Michael B. Otteneder, Devin Tesar, Gerry Kolaitis, Jennifer Visich, Yong Ying, Zhihua J. Qiu, Amita Joshi, Nicole Justies
Publikováno v:
mAbs. 4:243-255
Subcutaneous (SC) delivery is a common route of administration for therapeutic monoclonal antibodies (mAbs) with pharmacokinetic (PK)/pharmacodynamic (PD) properties requiring long-term or frequent drug administration. An ideal in vivo preclinical mo
Autor:
C. Andrew Boswell, Kiran Mukhyala, Paul J. Fielder, Devin Tesar, Frank-Peter Theil, Leslie A. Khawli
Publikováno v:
Bioconjugate Chemistry. 21:2153-2163
Antibody pharmacokinetics and pharmacodynamics are often governed by biological processes such as binding to antigens and other cognate receptors. Emphasis must also be placed, however, on fundamental physicochemical properties that define antibodies