Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Devin T. Wiley"'
Autor:
Mark E. Davis, Eloise Luevanos, Joseph Chao, Paul Frankel, Yun Yen, Devin T. Wiley, Scott Eliasof, Andrew J. Clark, Marwan Fakih, Vincent Chung, James Lin, Edward Graeme Garmey, Dean Lim
Publikováno v:
Journal of Gastrointestinal Oncology. 8:962-969
Background: Camptothecin (CPT) derivatives such as irinotecan have activity in 2nd-line therapy in advanced GEC with reported response rates of 0-15%. CRLX101 is an investigational nanoparticle-drug conjugate (NDC) with a CPT payload. Preclinical evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41936fc957f801f729a25c78da08c4c
https://doi.org/10.21037/jgo.2017.08.10
https://doi.org/10.21037/jgo.2017.08.10
Autor:
Paul Webster, Yun Yen, Joseph Chao, Devin T. Wiley, Jonathan E. Zuckerman, James Lin, Mark E. Davis, Andrew J. Clark
Publikováno v:
Proceedings of the National Academy of Sciences. 113:3850-3854
Nanoparticle-based therapeutics are being used to treat patients with solid tumors. Whereas nanoparticles have been shown to preferentially accumulate in solid tumors of animal models, there is little evidence to prove that intact nanoparticles local
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26eb843d2fcd974c2af4aaf4803bc13a
https://doi.org/10.1073/pnas.1603018113
https://doi.org/10.1073/pnas.1603018113
Autor:
Christian G. Peters, Joseph Chao, Mark E. Davis, Jungyeon Hwang, Douglas Lazarus, Thomas Schluep, James Lin, Yun Yen, Roy I. Case, Han Han, Scott Eliasof, Devin T. Wiley, Jonathan E. Zuckerman, Roderic O. Cole
Publikováno v:
Proceedings of the National Academy of Sciences. 110:15127-15132
Nanoparticles are currently being investigated in a number of human clinical trials. As information on how nanoparticles function in humans is difficult to obtain, animal studies that can be correlative to human behavior are needed to provide guidanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021294314f074b338d370135c0ed76f8
https://doi.org/10.1073/pnas.1309566110
https://doi.org/10.1073/pnas.1309566110
Receptor-mediated transcytosis across the blood–brain barrier (BBB) may be a useful way to transport therapeutics into the brain. Here we report that transferrin (Tf)-containing gold nanoparticles can reach the brain parenchyma from systemic admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16662d573a98e96d41e85266199696ef
https://resolver.caltech.edu/CaltechAUTHORS:20130805-094119782
https://resolver.caltech.edu/CaltechAUTHORS:20130805-094119782
Autor:
Eloise Luevanos, Dean Lim, Mark E. Davis, Joseph Chao, Andrew J. Clark, Scott Eliasof, Devin T. Wiley, James Lin, Vincent Chung, Edward Graeme Garmey, Yun Yen, Paul Frankel, Marwan Fakih
Publikováno v:
Journal of Clinical Oncology. 34:44-44
44 Background: Camptothecin (CPT) derivatives such as irinotecan have activity in 2nd-line therapy in advanced GEC with reported response rates of 0-15%. CRLX101 is an investigational nanoparticle-drug conjugate (NDC) with a CPT payload. Preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4537faabb9ff11bd1e0552750c91da23
https://doi.org/10.1200/jco.2016.34.4_suppl.44
https://doi.org/10.1200/jco.2016.34.4_suppl.44
Autor:
Jonathan E. Zuckerman, Joseph Chao, Devin T. Wiley, Yun Yen, Mark E. Davis, Paul Webster, Andrew J. Clark, Scott Eliasof, James Lin
Publikováno v:
Molecular Cancer Therapeutics. 14:B33-B33
Background: Nanoparticle-based therapeutics are thought to rely on the enhanced permeability and retention effect to preferentially localize in solid tumors and not healthy tissue. These phenomena are rationalized primarily from animal models of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6780035fd6dbdb8b7bfb859df15c401
https://doi.org/10.1158/1535-7163.targ-15-b33
https://doi.org/10.1158/1535-7163.targ-15-b33