Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Devin R. Lindsey"'
1
The ΔfbpA attenuated candidate vaccine from Mycobacterium tuberculosis, H37Rv primes for a stronger T-bet dependent Th1 immunity in mice
Autor: Amanda K. Smith, Lisa Y. Armitige, Ashish Arora, Kimberly S. Schluns, Devin R. Lindsey, Akshay Meher, Chinnaswamy Jagannath, Cherie Michelle Roche
Publikováno v: Tuberculosis. 91:S96-S104
The ΔfbpA candidate vaccine derived from Mycobacterium tuberculosis (H37Rv) (Mtb) protects mice better than BCG against tuberculosis, and we investigated the hypothesis that ΔfbpA may induce a stronger Th1 immunity. Since T-bet transcription factor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d005100bf5023adea595ddbd048c1b8
https://doi.org/10.1016/j.tube.2011.10.018
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2
Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells
Autor: Chinnaswamy Jagannath, Robert L. Hunter, Subramanian Dhandayuthapani, N. Tony Eissa, Devin R. Lindsey, Yi Xu
Publikováno v: Nature Medicine. 15:267-276
The variable efficacy of Bacille Calmette Guerin (BCG) vaccination against tuberculosis has prompted efforts to improve the vaccine. In this study, we used autophagy to enhance vaccine efficacy against tuberculosis in a mouse model. We examined the e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adbcef490cadc1bb6677049f14e9ba0
https://doi.org/10.1038/nm.1928
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4
The Reduced Bactericidal Function of Complement C5-Deficient Murine Macrophages Is Associated with Defects in the Synthesis and Delivery of Reactive Oxygen Radicals to Mycobacterial Phagosomes
Autor: Christopher R. Singh, D. Sundarsingh Daniel, Amanda K. Smith, Subramanian Dhandayuthapani, Chinnaswamy Jagannath, Robert L. Hunter, Devin R. Lindsey, Guixiang Dai
Publikováno v: The Journal of Immunology. 177:4688-4698
Complement C5-deficient (C5−/−) macrophages derived from B.10 congenic mice were found to be defective in killing intracellular Mycobacterium tuberculosis (MTB). They were bacteriostatic after activation with IFN-γ alone but bactericidal in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbd61e5b2c1a1b1d10daad92e07e38ff
https://doi.org/10.4049/jimmunol.177.7.4688
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5
Anti-tuberculosis immunity induced in mice by vaccination with Mycobacterium smegmatis over-expressing Antigen 85B is due to the increased influx of IFNγ-positive CD4 T cells into the lungs
Autor: Chinnaswamy Jagannath, Subramanian Dhandayuthapani, Devin R. Lindsey
Publikováno v: Tuberculosis. 89:S46-S48
BCG vaccine is unsafe for use in patients with AIDS. Mycobacterium smegmatis (Msm), an avirulent species unlike virulent Mycobacterium tuberculosis (H37Rv, Mtb) has been used as a carrier vaccine with ambiguous results due to the elicitation of poor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f89a389d810637a24240465820d1eb7
https://doi.org/10.1016/s1472-9792(09)70011-3
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6
A defect in the synthesis of Interferon-γ by the T cells of Complement-C5 deficient mice leads to enhanced susceptibility for tuberculosis
Autor: Rick A. Wetsel, Amanda K. Smith, Jeffrey K. Actor, John R. Klein, Mary Anne Mashruwala, Margaret Moczygemba, Devin R. Lindsey, Chinnaswamy Jagannath
Interferon-γ (IFNγ) plays a major role during host defense against Mycobacterium tuberculosis (Mtb). T cells produce IFNγ in response to IL-12 and IL-18 secreted from Mtb infected macrophages. IFNγ in turn, induces nitric oxide secretion in macro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b9b117872909b3d9b76195fc12853bb
https://europepmc.org/articles/PMC3263371/
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7
Complement C5a anaphylatoxin is an innate determinant of dendritic cell-induced Th1 immunity to Mycobacterium bovis BCG infection in mice
Autor: Amanda K. Smith, Rick A. Wetsel, Devin R. Lindsey, Mary Anne Mashruwala, Robert L. Hunter, David L. Haviland, Rachel A. Moulton, Chinnaswamy Jagannath
Publikováno v: Journal of leukocyte biology. 82(4)
During acquired immunity to Mycobacterium bovis bacillus Calmette-Guerin (BCG) infection in mice, dendritic cells (DCs) present mycobacterial antigens to naive T cells to prime an immune response. Complement C5a (anaphylatoxin) secreted by mycobacter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a574a186fe3a36240d5cc4af541f6842
https://pubmed.ncbi.nlm.nih.gov/17675563
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8
Mycobacteria-primed macrophages and dendritic cells induce an up-regulation of complement C5a anaphylatoxin receptor (CD88) in CD3+ murine T cells
Autor: Rick A. Wetsel, Devin R. Lindsey, Mary Anne Connelly, Rachel A. Moulton, Meenal Sinha, Chinnaswamy Jagannath, Amanda K. Smith
Publikováno v: Journal of leukocyte biology. 81(1)
Complement C5a anaphylatoxin is a potent activator of macrophages, neutrophils, and dendritic cells (DC) and binds the C5a receptor (C5a-R; CD88). Although C5a is chemotactic for T cells, expression of C5a-R on murine T cells has been disputed. We re
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf204545eb99404325409aa818e745e
https://pubmed.ncbi.nlm.nih.gov/17284680
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