Bioinspired Design of Artificial Signaling Systems

Autor: Jeffrey C. Way, Devin R. Burrill, Pamela A. Silver

Publikováno v: Biochemistry. 62:178-186

Natural systems use weak interactions and avidity effects to give biological systems high specificity and signal-to-noise ratios. Here we describe design principles for engineering fusion proteins that target therapeutic fusion proteins to membrane-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728032649f78e5ef9d36f4052d681513
https://doi.org/10.1021/acs.biochem.2c00368

Portable, On-Demand Biomolecular Manufacturing

Autor: Fern R. McSorley, Jeong Wook Lee, Yoshikazu Furuta, Christopher N. Boddy, Keith Pardee, Nina M. Donghia, Neel Joshi, Shimyn Slomovic, Peter Q. Nguyen, Andyna Vernet, Tom Ferrante, James J. Collins, Michael P. Lewandowski, Devin R. Burrill

Publikováno v: Prof. Collins via Howard Silver

Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs, therapeutic proteins, and other commodities. However, the need for specialized equipment and refrigeration for production and distribution poses a challenge for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5b56fd1b43ac288a983aae822265d1
https://orcid.org/0000-0002-5560-8246

Synthetic memory circuits for tracking human cell fate

Autor: Devin R. Burrill, Mara C. Inniss, Patrick M. Boyle, Pamela A. Silver

Publikováno v: Genes & Development. 26:1486-1497

A variety of biological phenomena, from disease progression to stem cell differentiation, are typified by a prolonged cellular response to a transient environmental cue. While biologically relevant, heterogeneity in these long-term responses is diffi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d2bd46131f6f30951ad748b657dcd8
https://doi.org/10.1101/gad.189035.112

A BioBrick compatible strategy for genetic modification of plants

Autor: Alain Viel, Morgan L Paull, Pamela A. Silver, Anugraha M. Raman, Mara C. Inniss, Patrick M. Boyle, Michael A Gedeon, Karmella A. Haynes, Jonathan G dewerd, Oliver Medvedik, Aaron Deardon, Christina M. Agapakis, Jacqueline Y Quinn, Tamara Jane Brenner, Kurt Schellenberg, Julia C. Winn, Mark R. Theilmann, Jagesh V. Shah, George M. Church, Devin R. Burrill, Lu Wang

Publikováno v: Journal of Biological Engineering, Vol 6, Iss 1, p 8 (2012)
Journal of Biological Engineering
Boyle, Patrick M; Burrill, Devin R; Inniss, Mara C; Agapakis, Christina M; Deardon, Aaron; DeWerd, Jonathan G; et al.(2012). A BioBrick compatible strategy for genetic modification of plants. Journal of Biological Engineering, 6(1), 8. doi: http://dx.doi.org/10.1186/1754-1611-6-8. Retrieved from: http://www.escholarship.org/uc/item/2n01v0mv

Background Plant biotechnology can be leveraged to produce food, fuel, medicine, and materials. Standardized methods advocated by the synthetic biology community can accelerate the plant design cycle, ultimately making plant engineering more widely a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7aab765f93622e92b543789e9e15937
http://www.jbioleng.org/content/6/1/8

High prevalence of BRCA1 and BRCA2 mutations in unselected Nigerian breast cancer patients

Autor: Qun Niu, Abayomi Odetunde, Walmy E. Sveen, Devin R. Burrill, Clemet Adebamowo, Jing Zhang, Fitsum Hagos, Olufunmilayo I. Olopade, Temidayo O. Ogundiran, Yonglan Zheng, Bifeng Zhang, James D. Fackenthal, Adeyinka G. Falusi, Dezheng Huo

Publikováno v: International journal of cancer. 131(5)

Inherited mutations in the BRCA1 and BRCA2 genes are the strongest genetic predictors of breast cancer and are the primary causes of familial breast/ovarian cancer syndrome. The frequency, spectrum and penetrance of mutant BRCA1/BRCA2 alleles have be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47153ee66494b14dda5b566d02a069e6
https://pubmed.ncbi.nlm.nih.gov/22034289