Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Devin Pillis"'
Autor:
Elisa Boscolo, Patricia Pastura, Sandra Schrenk, Jillian Goines, Rachael Kang, Devin Pillis, Punam Malik, Timothy D. Le Cras
Publikováno v:
Angiogenesis. 25:331-342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7064664e88f9f0520fd4cb852f6cc832
https://doi.org/10.1007/s10456-022-09836-7
https://doi.org/10.1007/s10456-022-09836-7
Autor:
Elisa, Boscolo, Patricia, Pastura, Sandra, Schrenk, Jillian, Goines, Rachael, Kang, Devin, Pillis, Punam, Malik, Timothy D, Le Cras
Publikováno v:
Angiogenesis
Somatic mutations in NRAS drive the pathogenesis of melanoma and other cancers but their role in vascular anomalies and specifically human endothelial cells is unclear. The goals of this study were to determine whether the somatic-activating NRAS(Q61
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be78c0ad8a39011de89b237b5ecea5fc
https://pubmed.ncbi.nlm.nih.gov/35391614
https://pubmed.ncbi.nlm.nih.gov/35391614
Autor:
Devin Pillis, Fan Zhang, Michael A. Goodman, Rajeswari Jayavaradhan, Paul R. Andreassen, Yue Zhang, Punam Malik
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Precise genome editing/correction of DNA double-strand breaks (DSBs) induced by CRISPR-Cas9 by homology-dependent repair (HDR) is limited by the competing error-prone non-homologous end-joining (NHEJ) DNA repair pathway. Here, we define a safer and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d12d2102432129ff5216fd8aa8e334
https://doi.org/10.1038/s41467-019-10735-7
https://doi.org/10.1038/s41467-019-10735-7
Publikováno v:
Journal of molecular biology. 431(1)
The efficient site-specific DNA double-strand breaks (DSB) created by CRISPR/Cas9 has revolutionized genome engineering and has great potential for editing hematopoietic stem/progenitor cells (HSPCs). However, detailed understanding of the variables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022da0abb547cc6ee37f085ec60c8aae
https://pubmed.ncbi.nlm.nih.gov/29751014
https://pubmed.ncbi.nlm.nih.gov/29751014
Autor:
Johannes Christiaan Maria van der Loo, Mehdi Keddache, Paritha Arumugam, Michael A. Goodman, Dennis D. Hickstein, Danielle Lynn, Phillip J. Dexheimer, Anastacia Loberg, Mohammed Nasimuzzaman, Devin Pillis, David W. Russell, Punam Malik, Thomas R. Bauer
Publikováno v:
Journal of virology. 92(1)
Strong viral enhancers in gammaretrovirus vectors have caused cellular proto-oncogene activation and leukemia, necessitating the use of cellular promoters in “enhancerless” self-inactivating integrating vectors. However, cellular promoters result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759ff39dabe4087e2778bef3f265441f
https://pubmed.ncbi.nlm.nih.gov/29046446
https://pubmed.ncbi.nlm.nih.gov/29046446
Autor:
Stella M. Davies, Archana Shreshta, Johannes C.M. Van der Loo, Jennifer Knight-Madden, Theodosia A. Kalfa, Frederic D. Bushman, Monika Asnani, Michael Grimley, Punam Malik, Omar Niss, Elke Grassman, Carolyn Lutzko, Lilith Reeves, Parinda A. Mehta, Amy Shova, Catherine E. Terrell, Sydney Felker, Loberg Anastacia, Charles T. Quinn, Karen Kalinyak, Scott Witting, Little Courtney, Sharat Chandra, Devin Pillis, Diana Nordling
Publikováno v:
Blood. 132:1021-1021
Background: Genetic transfer of an anti-sickling β87-globin lentiviral vector (LV) into hematopoietic stem cells (HSC) followed by myeloablative transplant has cured one child with sickle cell anemia (SCA) (NEJM 2017), although it was not successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a786221f974407d89ab85a36eb60cc5
https://doi.org/10.1182/blood-2018-99-119591
https://doi.org/10.1182/blood-2018-99-119591
Autor:
Vijay K. Kalra, Timothy D. Le Cras, Nancy Ratner, Shiva Kumar Shanmukhappa, Eric B. Brandt, Gurjit K. Khurana Hershey, Devin Pillis, Peter Carmeliet, Bart Jonck, Anastacia Loberg, Tilat A. Rizvi, Paritha Arumugam, Swati Tiwari, Marsha Wills-Karp, Marthe Sandrine Eiymo Mwa Mpollo, Mark Lindsey, Punam Malik
Publikováno v:
The Journal of clinical investigation. 126(2)
Airway hyperresponsiveness (AHR) affects 55%-77% of children with sickle cell disease (SCD) and occurs even in the absence of asthma. While asthma increases SCD morbidity and mortality, the mechanisms underlying the high AHR prevalence in a hemoglobi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826fb5f3a83ec91667453853d15b428d
https://pubmed.ncbi.nlm.nih.gov/26690703
https://pubmed.ncbi.nlm.nih.gov/26690703
Autor:
Johannes C.M. Van der Loo, Dennis D. Hickstein, Mehdi Keddache, Punam Malik, Paritha Arumugam, David W. Russell, Devin Pillis, Thomas R. Bauer, Michael A. Goodman, Danielle Lynn
Publikováno v:
Blood. 128:1002-1002
Strong viral enhancers in γ-retrovirus vectors (GV) have caused cellular proto-oncogene activation and leukemia in gene therapy trials, necessitating the use of cellular promoters in enhancer-less integrating vectors. However, data is now emerging t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b0ed97db762ee982cf0cf73945963ae
https://doi.org/10.1182/blood.v128.22.1002.1002
https://doi.org/10.1182/blood.v128.22.1002.1002