MicroRNA Content of Ewing Sarcoma Derived Extracellular Vesicles Leads to Biomarker Potential and Identification of a Previously Undocumented EWS-FLI1 Translocation

Autor: Jennifer Crow, Glenson Samuel, Emily Farrow, Margaret Gibson, Jefferey Johnston, Erin Guest, Neil Miller, Dong Pei, Devin Koestler, Harsh Pathak, Xiaobo Liang, Cooper Mangels, Andrew K Godwin

Publikováno v: Biomarker Insights, Vol 17 (2022)

Objective: Ewing Sarcoma Family of Tumors (ESFT) are a highly aggressive pediatric bone and soft tissue malignancy with poor outcomes in the refractory and recurrent setting. Over 90% of Ewing Sarcoma (ES) tumors are driven by the pathognomonic EWS-E

Externí odkaz: https://doaj.org/article/39a4540fb45c44d9b9dd3f9070920ef8

Patients with type 2 diabetes and elevated fibrosis‐4 are under‐referred to hepatology and have unrecognized hepatic decompensation

Autor: Winston Dunn, Xing Song, Devin Koestler, Kristine Grdinovac, Eyad Al‐hihi, John Chen, Ryan Taylor, Jessica Wilson, Steven A. Weinman

Publikováno v: Journal of Gastroenterology and Hepatology. 37:1815-1821

The American Association for the Study of Liver Diseases recommends a high index of suspicion for nonalcoholic steatohepatitis and advanced fibrosis in patients with type 2 diabetes (T2D) and an elevated fibrosis-4 index (FIB-4). We investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a986691ea6a3aefa71071b6cf3b63491
https://doi.org/10.1111/jgh.15900

Human cytomegalovirus alters immune cell profile with potential implications for patient survival in head and neck cancer

Autor: Heather H Nelson, Emma Contestabile, DeVon Hunter-Schlichting, Devin Koestler, Michael Pawlita, Tim Waterboer, Brock C Christensen, Curtis L Petersen, Jeffrey S Miller, Karl T Kelsey

Publikováno v: Carcinogenesis

Cytomegalovirus (CMV) is a highly prevalent human herpes virus that exerts a strong influence on immune repertoire which may influence cancer risk. We have tested whether CMV immunoglobulin G (IgG) serostatus is associated with immune cell proportion

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54668afc7135678d82c2e646ba12902b
https://europepmc.org/articles/PMC9167029/

Prediction of overall survival for patients with metastatic castration-resistant prostate cancer: development of a prognostic model through a crowdsourced challenge with open clinical trial data

Autor: Justin Guinney, Tao Wang, Teemu D Laajala, Kimberly Kanigel Winner, J Christopher Bare, Elias Chaibub Neto, Suleiman A Khan, Gopal Peddinti, Antti Airola, Tapio Pahikkala, Tuomas Mirtti, Thomas Yu, Brian M Bot, Liji Shen, Kald Abdallah, Thea Norman, Stephen Friend, Gustavo Stolovitzky, Howard Soule, Christopher J Sweeney, Charles J Ryan, Howard I Scher, Oliver Sartor, Yang Xie, Tero Aittokallio, Fang Liz Zhou, James C Costello, Catalina Anghe, Helia Azima, Robert Baertsch, Pedro J Ballester, Chris Bare, Vinayak Bhandari, Cuong C Dang, Maria Bekker-Nielsen Dunbar, Ann-Sophie Buchardt, Ljubomir Buturovic, Da Cao, Prabhakar Chalise, Junwoo Cho, Tzu-Ming Chu, R Yates Coley, Sailesh Conjeti, Sara Correia, Ziwei Dai, Junqiang Dai, Philip Dargatz, Sam Delavarkhan, Detian Deng, Ankur Dhanik, Yu Du, Aparna Elangovan, Shellie Ellis, Laura L Elo, Shadrielle M Espiritu, Fan Fan, Ashkan B Farshi, Ana Freitas, Brooke Fridley, Christiane Fuchs, Eyal Gofer, Gopalacharyulu Peddinti, Stefan Graw, Russ Greiner, Yuanfang Guan, Jing Guo, Pankaj Gupta, Anna I Guyer, Jiawei Han, Niels R Hansen, Billy HW Chang, Outi Hirvonen, Barbara Huang, Chao Huang, Jinseub Hwang, Joseph G Ibrahim, Vivek Jayaswa, Jouhyun Jeon, Zhicheng Ji, Deekshith Juvvadi, Sirkku Jyrkkiö, Kimberly Kanigel-Winner, Amin Katouzian, Marat D Kazanov, Shahin Khayyer, Dalho Kim, Agnieszka K Golinska, Devin Koestler, Fernanda Kokowicz, Ivan Kondofersky, Norbert Krautenbacher, Damjan Krstajic, Luke Kumar, Christoph Kurz, Matthew Kyan, Michael Laimighofer, Eunjee Lee, Wojciech Lesinski, Miaozhu Li, Ye Li, Qiuyu Lian, Xiaotao Liang, Minseong Lim, Henry Lin, Xihui Lin, Jing Lu, Mehrad Mahmoudian, Roozbeh Manshaei, Richard Meier, Dejan Miljkovic, Krzysztof Mnich, Nassir Navab, Elias C Neto, Yulia Newton, Subhabrata Pal, Byeongju Park, Jaykumar Patel, Swetabh Pathak, Alejandrina Pattin, Donna P Ankerst, Jian Peng, Anne H Petersen, Robin Philip, Stephen R Piccolo, Sebastian Pölsterl, Aneta Polewko-Klim, Karthik Rao, Xiang Ren, Miguel Rocha, Witold R. Rudnicki, Hyunnam Ryu, Hagen Scherb, Raghav Sehgal, Fatemeh Seyednasrollah, Jingbo Shang, Bin Shao, Howard Sher, Motoki Shiga, Artem Sokolov, Julia F Söllner, Lei Song, Josh Stuart, Ren Sun, Nazanin Tahmasebi, Kar-Tong Tan, Lisbeth Tomaziu, Joseph Usset, Yeeleng S Vang, Roberto Vega, Vitor Vieira, David Wang, Difei Wang, Junmei Wang, Lichao Wang, Sheng Wang, Yue Wang, Russ Wolfinger, Chris Wong, Zhenke Wu, Jinfeng Xiao, Xiaohui Xie, Doris Xin, Hojin Yang, Nancy Yu, Xiang Yu, Sulmaz Zahedi, Massimiliano Zanin, Chihao Zhang, Jingwen Zhang, Shihua Zhang, Yanchun Zhang, Hongtu Zhu, Shanfeng Zhu, Yuxin Zhu

Publikováno v: Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Lancet Oncol. 18, 132-142 (2017)
Guinney, J, Wang, T, Laajala, T D, Winner, K K, Bare, J C, Neto, E C, Khan, S A, Peddinti, G, Airola, A, Pahikkala, T, Mirtti, T, Yu, T, Bot, B M, Shen, L, Abdallah, K, Norman, T, Friend, S, Stolovitzky, G, Soule, H, Sweeney, C J, Ryan, C J, Scher, H I, Sartor, O, Xie, Y, Aittokallio, T, Zhou, F L, Costello, J C & Prostate Cancer Challenge DREAM Community 2017, ' Prediction of overall survival for patients with metastatic castration-resistant prostate cancer : development of a prognostic model through a crowdsourced challenge with open clinical trial data ', The Lancet: Oncology, vol. 18, no. 1, pp. 132-142 . https://doi.org/10.1016/S1470-2045(16)30560-5

Background: Improvements to prognostic models in metastatic castration-resistant prostate cancer have the potential to augment clinical trial design and guide treatment strategies. In partnership with Project Data Sphere, a not-for-profit initiative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e29c71ca03dc8018abacbcb6b41b185
https://doi.org/10.1016/s1470-2045(16)30560-5

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Autor: Devin Koestler, Alistair E. W. Johnson, Tom Pollard, Leo Anthony Celi, Janet D. Pierce, Teresa Rincon, Jesse D. Raffa

Publikováno v: Critical Care Medicine. 47:759

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59d2d21cdba82d03b242065822234760
https://doi.org/10.1097/01.ccm.0000552309.57308.ff