Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Devin G Roller"'
Publikováno v:
eLife, Vol 9 (2020)
We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR direct
Externí odkaz:
https://doaj.org/article/314ac06112aa4f8599d533907962de2d
Autor:
Philip I. Chow, Devin G. Roller, Mehdi Boukhechba, Kelly M. Shaffer, Lee M. Ritterband, Matthew J. Reilley, Tri M. Le, Paul R. Kunk, Todd W. Bauer, Daniel G. Gioeli
Publikováno v:
Internet Interventions, Vol 34, Iss , Pp 100644- (2023)
As mobile and wearable devices continue to grow in popularity, there is strong yet unrealized potential to harness people's mobile sensing data to improve our understanding of their cellular and biologically-based diseases. Breakthrough technical inn
Externí odkaz:
https://doaj.org/article/c768ed8615f84bf284ffb233c114678b
Autor:
Devin G. Roller, Stephen A. Hoang, Kristopher D. Rawls, Katherine A. Owen, Michael B. Simmers, Robert A. Figler, Julia D. Wulfkuhle, Emanuel F. Petricoin, Brian R. Wamhoff, Daniel Gioeli
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clini
Externí odkaz:
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8
Autor:
Sylwia Hasterok, Thomas G. Scott, Devin G. Roller, Adam Spencer, Arun B. Dutta, Kizhakke M Sathyan, Daniel E. Frigo, Michael J. Guertin, Daniel Gioeli
The clinical success of combined androgen deprivation therapy (ADT) and radiation therapy (RT) in prostate cancer (PCa) created interest in understanding the mechanistic links between androgen receptor (AR) signaling and the DNA damage response (DDR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c389664a3c8cb66537286b0269663bc4
https://doi.org/10.1101/2023.05.13.540653
https://doi.org/10.1101/2023.05.13.540653
Autor:
Daniel Gioeli, Michael J. Weber, Aaron Mackey, Karin Jensen, Brian J. Capaldo, Mark Axelrod, Devin G. Roller
Recent data show that extracellular signals are transmitted through a network of proteins rather than hierarchical signaling pathways, suggesting that the inhibition of a single component of a canonical pathway is insufficient for the treatment of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5132c624f0ec19884130743959be8825
https://doi.org/10.1158/1535-7163.c.6535764.v1
https://doi.org/10.1158/1535-7163.c.6535764.v1
Autor:
Daniel Gioeli, Michael J. Weber, Aaron Mackey, Karin Jensen, Brian J. Capaldo, Mark Axelrod, Devin G. Roller
PDF file, 428K, The combination of sorafenib and diclofenac causes cell death.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02b556e5ee766cee90e16befefbf6aad
https://doi.org/10.1158/1535-7163.22497999
https://doi.org/10.1158/1535-7163.22497999
Autor:
Devin G. Roller, Sylwia Hasterok, Rosalie Sleppy, Patryk Krakowiak, Hannah Ashe, Daniel Gioeli
Publikováno v:
The FEBS Journal. 288:6112-6126
Prostate cancer (PCa) is a very complex disease that is a major cause of death in men worldwide. Currently, PCa dependence on the androgen receptor (AR) has resulted in use of AR antagonists and anti-androgen therapies that reduce endogenous steroid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd144ae306f796e253fbf4513836827
https://doi.org/10.1111/febs.15804
https://doi.org/10.1111/febs.15804
Autor:
Brian R. Wamhoff, Daniel Gioeli, Devin G. Roller, Kristopher D. Rawls, Katherine A. Owen, Emanuel F. Petricoin, Julia Wulfkuhle, Stephen A. Hoang, Robert A. Figler, Michael B. Simmers
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Lung cancer rates are rising globally and non-small cell lung cancer (NSCLC) has a five year survival rate of only 24%. Unfortunately, the development of drugs to treat cancer is severely hampered by the inefficiency of translating pre-clinical studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15b6fb5abd08967fc19b35686028bfdb
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8
https://doaj.org/article/8c42edff85c244b88abc08fd238c4aa8
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
We have previously demonstrated that checkpoint kinase 2 (CHK2) is a critical negative regulator of androgen receptor (AR) transcriptional activity, prostate cancer (PCa) cell growth, and androgen sensitivity. We have now uncovered that the AR direct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1752bec1bd14ff7e4d05380e40c6aa
https://elifesciences.org/articles/51378
https://elifesciences.org/articles/51378