Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Devin Franklin Welty"'
Autor:
Deirdre Murphy, Ting Chen, Dorothy G. Flood, Gerhard Koenig, Devin Franklin Welty, Yi Tao, Xing Chen, Scott Nolan, Sudarshan Kapadnis, Don Costa, Melody Wen, Hilliary Hodgdon, Cuyue Tang
Publikováno v:
Biochemical Pharmacology. 91:543-551
Two investigational compounds (FRM-1, (R)-7-fluoro-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide and FRM-2, (R)-7-cyano-N-(quinuclidin-3-yl)benzo[b]thiophene-2-carboxamide) resided in rat brain longer than in systemic circulation. In Caco-2 dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aa77931e039a2c0a620ef685b98b22f
https://doi.org/10.1016/j.bcp.2014.07.023
https://doi.org/10.1016/j.bcp.2014.07.023
Publikováno v:
Behavioural Pharmacology, 26(4), 403-406. LIPPINCOTT WILLIAMS & WILKINS
We investigated whether the effects of acutely administered EVP-6124, an alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) agonist, on cognition were maintained after 6-day continuous minipump administration. Performance in a delay-dependent f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170a3105d8faf106645002e266245837
https://cris.maastrichtuniversity.nl/en/publications/ba6b2ec1-78de-43fb-90f1-017c5efd8e9d
https://cris.maastrichtuniversity.nl/en/publications/ba6b2ec1-78de-43fb-90f1-017c5efd8e9d
Autor:
Devin Franklin Welty, Lin Jin, Yanfeng Wang, Matthias A. Hediger, Margaret Dykes-Hoberg, Lynn A. Bristol, Carlos A. Pardo, Jeffrey D. Rothstein, Yoshikatsu Kanai, Ralph W. Kuncl, Jerry P Schielke
Publikováno v:
Neuron. 16:675-686
Three glutamate transporters have been identified in rat, including astroglial transporters GLAST and GLT-1 and a neuronal transporter EAAC1. Here we demonstrate that inhibition of the synthesis of each glutamate transporter subtype using chronic ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0355497153ebe9edca09f95b3fe49e
https://doi.org/10.1016/s0896-6273(00)80086-0
https://doi.org/10.1016/s0896-6273(00)80086-0
Effects of anticonvulsant drug gabapentin on the enzymes in metabolic pathways of glutamate and GABA
Publikováno v:
Epilepsy Research. 22:1-11
Gabapentin is a novel anticonvulsant drug. The anticonvulsant mechanism of gabapentin is not known. Based on the amino acid structure of gabapentin we explored its possible effects on glutamate and gamma-aminobutyric acid (GABA) metabolism in brain a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eaf4f559dc55241b20ff4dcf91a073b
https://doi.org/10.1016/0920-1211(95)00028-9
https://doi.org/10.1016/0920-1211(95)00028-9
Autor:
Devin Franklin Welty, Ellen Urda, Brian R. Krause, Donald G. Robertson, Michael J. Graziano, Gary D. Pilcher, Grushenka H. I. Wolfgang
Publikováno v:
Biochemical Pharmacology. 49:799-808
Induction of hepatic microsomal cytochrome P450 produced by carbamic acid [[2,6-bis(1-methylethyl)phenoxy]sulfonyl]-2,6-bis(1-methylethyl) phenyl ester, monosodium salt (PD138142-15), a novel water-soluble inhibitor of acyl-CoA:cholesterol acyltransf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8af5f14db022458b7b8874539ba996d
https://doi.org/10.1016/0006-2952(94)00540-3
https://doi.org/10.1016/0006-2952(94)00540-3
Publikováno v:
Epilepsy Research. 16:175-181
The concentration-time profile of [14C]gabapentin (GBP) in plasma and brain interstitial fluid (ISF) was determined following a single 15 mg/kg intravenous bolus dose to rats. Brain ISF was sampled with a microdialysis probe in striatum. Blood was al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7cf72b47c8a1a17087b238508a3c65c
https://doi.org/10.1016/0920-1211(93)90078-l
https://doi.org/10.1016/0920-1211(93)90078-l
Autor:
Philip Boden, Charles Taylor, Nicolas S. Gee, David J. Dooley, Ti-Zhi Su, Devin Franklin Welty, Jeffery D. Kocsis, Lakhbir Singh, Jason P. Brown
Publikováno v:
Epilepsy research. 29(3)
Although the cellular mechanisms of pharmacological actions of gabapentin (Neurontin) remain incompletely described, several hypotheses have been proposed. It is possible that different mechanisms account for anticonvulsant, antinociceptive, anxiolyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0b2af30f5fb87a31defd06ece5a0cb
https://pubmed.ncbi.nlm.nih.gov/9551785
https://pubmed.ncbi.nlm.nih.gov/9551785
Publikováno v:
Journal of clinical pharmacology. 34(10)
A four-way cross-over study was performed to assess the temporal effect of food on the rate and extent of tacrine (Cognex, THA) absorption after drug administration to healthy, older volunteers. Each volunteer received four single 40-mg THA doses at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b98be7ad88445ae0606d3491a1a5dba
https://pubmed.ncbi.nlm.nih.gov/7836549
https://pubmed.ncbi.nlm.nih.gov/7836549