Zobrazeno 1 - 10
of 1 930
pro vyhledávání: '"Devin C"'
Autor:
Ze Zhang, Kartik Sehgal, Keisuke Shirai, Rondi A. Butler, John K. Wiencke, Devin C. Koestler, Geat Ramush, Min Kyung Lee, Annette M. Molinaro, Hannah G. Stolrow, Ariel Birnbaum, Lucas A. Salas, Robert I. Haddad, Karl T. Kelsey, Brock C. Christensen
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-10 (2024)
Abstract Tissue biomarkers for immune checkpoint inhibitor (ICI) response are limited by tumor sample heterogeneity and availability. This study identifies clinically actionable pretreatment blood biomarkers that are associated with ICI treatment res
Externí odkaz:
https://doaj.org/article/fdd69c008307400fa3cabca4cbe4d4c4
Autor:
Steven C. Pike, John K. Wiencke, Ze Zhang, Annette M. Molinaro, Helen M. Hansen, Devin C. Koestler, Brock C. Christensen, Karl T. Kelsey, Lucas A. Salas
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-19 (2024)
Abstract A scalable platform for cell typing in the glioma microenvironment can improve tumor subtyping and immune landscape detection as successful immunotherapy strategies continue to be sought and evaluated. DNA methylation (DNAm) biomarkers for m
Externí odkaz:
https://doaj.org/article/c2f50a1e2f134257a5b02c38f46d2ea6
Autor:
Devin C. Cohen, Alexander Sumaroka, Joshua A. Paulos, Tara C. Mitchell, Arlene J. Santos, Erin C. O'Neil, Emma C. Bedoukian, Grazyna Adamus, Artur V. Cideciyan, Tomas S. Aleman
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 36, Iss , Pp 102098- (2024)
Purpose: To describe the retinal phenotype of an unusual case of anti-TRPM1 autoantibody-positive unilateral melanoma-associated retinopathy (MAR) triggered by nivolumab therapy and compare with the phenotype of TRPM1-associated Congenital Stationary
Externí odkaz:
https://doaj.org/article/b20cab0415ad4cbdb0b901937761b9df
Publikováno v:
American Journal of Ophthalmology Case Reports, Vol 36, Iss , Pp 102088- (2024)
Purpose: To describe a patient with a unique retinal phenotype of probable Susac syndrome. Observations: A 47-year-old female who presented with bilateral tinnitus and vision changes was found to have bilateral sensorineural hearing loss and many bil
Externí odkaz:
https://doaj.org/article/5fd4a7832e2c444a89d114db8d08499d
Autor:
Patrick L. Wagner, Jianwu Xie, Devin C. Flaherty, Hyun Park, Chelsea Knotts, Justine Debelius, Curtis Tilves, Neda Dadgar, Kunhong Xiao, Ali H. Zaidi, Louis Gil Acevedo, William LaFramboise, Ni Zhao, Cynthia Sears, Noel Mueller
Publikováno v:
Frontiers in Gastroenterology, Vol 3 (2024)
BackgroundIntra-tumoral lymphocytes hold prognostic and predictive significance in colorectal cancer (CRC). The internationally validated Immunoscore™ predicts CRC survival risk by averaging percentile scores of tumor-associated CD3+ and CD8+ cell
Externí odkaz:
https://doaj.org/article/48defe3cde3b4de29ccb665df38a6fe5
Autor:
Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler, Karl T. Kelsey
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of leukocytes in periphera
Externí odkaz:
https://doaj.org/article/208d74f53e1241a0b7e56fbcf8f4dbbb
Autor:
Cynthia Sears, Patrick Wagner, William A LaFramboise, Jianwu Xie, Neda Dadgar, Devin C Flaherty, Louis Gil Acevedo, Kunhong Kevin Xiao, Curtis Tilves, Justine Debelius, Ni Zhao, Noel Mueller
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/87a1bbec024949f3bbdf05f9205aa6f4
Autor:
Jennifer L. Delzeit, Devin C. Koestler
Publikováno v:
Frontiers in Applied Mathematics and Statistics, Vol 9 (2023)
Numerous methods and approaches have been developed for generating time-to-event data from the Cox Proportional Hazards (CPH) model; however, they often require specification of a parametric distribution for the baseline hazard even though the CPH mo
Externí odkaz:
https://doaj.org/article/f3ea542879ce48ae91dd9c5b38e7396d
Autor:
Roberta Freitas-Lemos, Devin C. Tomlinson, Yu-Hua Yeh, Candice L. Dwyer, Hongying Daisy Dai, Adam Leventhal, Allison N. Tegge, Warren K. Bickel
Publikováno v:
Preventive Medicine Reports, Vol 35, Iss , Pp 102280- (2023)
Despite being a major threat to health, vaccine hesitancy (i.e., refusal or reluctance to vaccinate despite vaccine availability) is on the rise. Using a longitudinal cohort of young adults (N = 1260) from Los Angeles County, California we investigat
Externí odkaz:
https://doaj.org/article/ee21b352d3264629a4bb285aa98dae17
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3224-3233 (2023)
JQ1 and GSK2801 are bromo domain inhibitors (BDI) known to exhibit enhanced anti-cancer activity when combined with other agents. However, the underlying molecular mechanisms behind such enhanced activity remain unclear. We used network-pharmacology
Externí odkaz:
https://doaj.org/article/3350c2ad0ec042c59c9f00e7009e7001