Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Devin Bready"'
Autor:
Gabriele Stephan, Sara Haddock, Shuai Wang, Hediye Erdjument-Bromage, Wenke Liu, Niklas Ravn-Boess, Joshua D. Frenster, Devin Bready, Julia Cai, Rebecca Ronnen, Jonathan Sabio-Ortiz, David Fenyo, Thomas A. Neubert, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114229- (2024)
Summary: GPR133 (ADGRD1) is an adhesion G-protein-coupled receptor that signals through Gαs/cyclic AMP (cAMP) and is required for the growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely un
Externí odkaz:
https://doaj.org/article/22cad31820a94f3da72fef14f8760c05
Autor:
Niklas Ravn-Boess, Nainita Roy, Takamitsu Hattori, Devin Bready, Hayley Donaldson, Christopher Lawson, Cathryn Lapierre, Aryeh Korman, Tori Rodrick, Enze Liu, Joshua D. Frenster, Gabriele Stephan, Jordan Wilcox, Alexis D. Corrado, Julia Cai, Rebecca Ronnen, Shuai Wang, Sara Haddock, Jonathan Sabio Ortiz, Orin Mishkit, Alireza Khodadadi-Jamayran, Aris Tsirigos, David Fenyö, David Zagzag, Julia Drube, Carsten Hoffmann, Fabiana Perna, Drew R. Jones, Richard Possemato, Akiko Koide, Shohei Koide, Christopher Y. Park, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113374- (2023)
Summary: Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Adhesion G protein-coupled receptors (aGPCRs) have attracted interest for their potential as treatment targets. Here, we show that CD97 (ADGRE5) is the most promi
Externí odkaz:
https://doaj.org/article/e954f101e34e4454841a124bf6a6e405
Autor:
Joshua D. Frenster, Hediye Erdjument-Bromage, Gabriele Stephan, Niklas Ravn-Boess, Shuai Wang, Wenke Liu, Devin Bready, Jordan Wilcox, Björn Kieslich, Manuel Jankovic, Caroline Wilde, Susanne Horn, Norbert Sträter, Ines Liebscher, Torsten Schöneberg, David Fenyo, Thomas A. Neubert, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112679- (2023)
Summary: The adhesion G-protein-coupled receptor GPR133 (ADGRD1) supports growth of the brain malignancy glioblastoma. How the extracellular interactome of GPR133 in glioblastoma modulates signaling remains unknown. Here, we use affinity proteomics t
Externí odkaz:
https://doaj.org/article/a9a9721bc5484f82b98d01af4ebdccdd
Autor:
Daniel P. Depledge, Kalanghad Puthankalam Srinivas, Tomohiko Sadaoka, Devin Bready, Yasuko Mori, Dimitris G. Placantonakis, Ian Mohr, Angus C. Wilson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Here, Depledge et al. use nanopore arrays for direct RNA sequencing to profile the HSV-1 transcriptome in productively infected cells. Sequencing of individual RNAs reveals a highly complex viral transcriptome including mRNAs encoding new viral fusio
Externí odkaz:
https://doaj.org/article/62e6f7e4a2564e61a8a33f67a99d8972
Autor:
Aram S. Modrek, Danielle Golub, Themasap Khan, Devin Bready, Jod Prado, Christopher Bowman, Jingjing Deng, Guoan Zhang, Pedro P. Rocha, Ramya Raviram, Charalampos Lazaris, James M. Stafford, Gary LeRoy, Michael Kader, Joravar Dhaliwal, N. Sumru Bayin, Joshua D. Frenster, Jonathan Serrano, Luis Chiriboga, Rabaa Baitalmal, Gouri Nanjangud, Andrew S. Chi, John G. Golfinos, Jing Wang, Matthias A. Karajannis, Richard A. Bonneau, Danny Reinberg, Aristotelis Tsirigos, David Zagzag, Matija Snuderl, Jane A. Skok, Thomas A. Neubert, Dimitris G. Placantonakis
Publikováno v:
Cell Reports, Vol 21, Iss 5, Pp 1267-1280 (2017)
Summary: Low-grade astrocytomas (LGAs) carry neomorphic mutations in isocitrate dehydrogenase (IDH) concurrently with P53 and ATRX loss. To model LGA formation, we introduced R132H IDH1, P53 shRNA, and ATRX shRNA into human neural stem cells (NSCs).
Externí odkaz:
https://doaj.org/article/6c38719ab387499d9cbeaef12ccef89b
Autor:
Danielle Golub, Nishanth Iyengar, Siddhant Dogra, Taylor Wong, Devin Bready, Karen Tang, Aram S. Modrek, Dimitris G. Placantonakis
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The identification of heterozygous neomorphic isocitrate dehydrogenase (IDH) mutations across multiple cancer types including both solid and hematologic malignancies has revolutionized our understanding of oncogenesis in these malignancies and the po
Externí odkaz:
https://doaj.org/article/f275d4fdff3c4d98b3f8c34da88e089d
Autor:
Gabriele Stephan, Hediye Erdjument-Bromage, Wenke Liu, Joshua D. Frenster, Niklas Ravn-Boess, Devin Bready, Julia Cai, David Fenyo, Thomas Neubert, Dimitris G. Placantonakis
Publikováno v:
bioRxiv
SummaryGPR133 (ADGRD1) is an adhesion G protein-coupled receptor that signals through Gαs and is required for growth of glioblastoma (GBM), an aggressive brain malignancy. The regulation of GPR133 signaling is incompletely understood. Here, we use p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12320b542b51842882d13c1b9c65f64
https://doi.org/10.1101/2023.02.09.527921
https://doi.org/10.1101/2023.02.09.527921
Autor:
Jin Kim Montclare, Youssef Wadghiri, Dimitris Placantanokis, Devin Bready, Joshua Frenster, James Tranos, Orin Mishkit, Bhattacharya Aparajita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::357e48bc0807fb26401d022a3a5aab32
https://doi.org/10.1021/scimeetings.2c00310
https://doi.org/10.1021/scimeetings.2c00310
Autor:
Joshua D. Frenster, Hediye Erdjument-Bromage, Wenke Liu, Gabriele Stephan, Niklas Ravn-Boess, Devin Bready, Jordan Wilcox, Björn Kieslich, Manuel Jankovic, Caroline Wilde, Susanne Horn, Norbert Sträter, Ines Liebscher, Torsten Schöneberg, David Fenyo, Thomas A. Neubert, Dimitris G. Placantonakis
GPR133 (ADGRD1), an adhesion G protein-coupled receptor, supports growth of glioblastoma, a brain malignancy. We demonstrated that GPR133 is intramolecularly cleaved, and that dissociation of its N-terminal and C-terminal fragments (NTF and CTF) at t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cf7322711fe62f2613d83c437a4780f
https://doi.org/10.1101/2022.06.15.496232
https://doi.org/10.1101/2022.06.15.496232
Autor:
Niklas Ravn-Boess, Nainita Bhowmick, Takamitsu Hattori, Varsha Prakash, Gabriele Stephan, Joshua Frenster, Devin Bready, Christopher Lawson, Jordan Wilcox, Dimitris Placantonakis
Publikováno v:
Neuro-Oncology. 24:vii265-vii265
Glioblastoma (GBM) is the most common and aggressive primary brain malignancy. Despite multimodal therapy, disease recurrence is inevitable. To identify novel vulnerabilities of GBM, we performed an arrayed CRISPR/Cas9 screen against select adhesion