Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Devin A King"'
Autor:
Sean L Beckwith, Erin K Schwartz, Pablo E García-Nieto, Devin A King, Graeme J Gowans, Ka Man Wong, Tessa L Eckley, Alexander P Paraschuk, Egan L Peltan, Laura R Lee, Wei Yao, Ashby J Morrison
Publikováno v:
PLoS Genetics, Vol 14, Iss 2, p e1007216 (2018)
Chromatin remodeling complexes are essential for gene expression programs that coordinate cell function with metabolic status. However, how these remodelers are integrated in metabolic stability pathways is not well known. Here, we report an expansiv
Externí odkaz:
https://doaj.org/article/a4cf6eb375c248adad872857fdf2a0b6
Autor:
Mary C. Andorfer, Devin T. King-Roberts, Christa N. Imrich, Balyn G. Brotheridge, Catherine L. Drennan
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106902- (2023)
Summary: Anaerobic microbial degradation of hydrocarbons is often initiated through addition of the hydrocarbon to fumarate by enzymes known as X-succinate synthases (XSSs). XSSs use a glycyl radical cofactor, which is installed by an activating enzy
Externí odkaz:
https://doaj.org/article/7f0ec84e99054e999b06e030f6a72697
Autor:
Siyeon Rhee, Jae I. Chung, Devin A. King, Gaetano D’amato, David T. Paik, Anna Duan, Andrew Chang, Danielle Nagelberg, Bikram Sharma, Youngtae Jeong, Maximilian Diehn, Joseph C. Wu, Ashby J. Morrison, Kristy Red-Horse
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Heart development requires compaction of the ventricular wall into a dense myocardium at mid-gestation. Here, Rhee and colleagues show that the chromatin remodeller Ino80 is critical for the formation of the coronary vasculature, and show that corona
Externí odkaz:
https://doaj.org/article/0d8c87a059fa43f486965f124732ed10
Autor:
Dmitry A. Gordenin, Jesse R. Dixon, Sarah Killcoyne, Erica Lynn, Peter J. Campbell, Manjunath Nimmakayalu, Rebecca C. Fitzgerald, Yanyan Tian, Sahil Seth, Yonathan Lissanu Deribe, John P. O'Brien, Akira Inoue, Victoria T. Le, Roel G.W. Verhaak, Kadir C. Akdemir, Leszek J. Klimczak, Moritz Gerstung, Rafael E. Herrera, Ya-Ping Lin, Lei Li, Justin M. Kim, Samirkumar B. Amin, P. Andrew Futreal, Frederick S. Robinson, Kin Chan, Ashby J. Morrison, Devin A. King
Publikováno v:
Nat Genet
Somatic mutations in driver genes may ultimately lead to the development of cancer. Understanding how somatic mutations accumulate in cancer genomes and the underlying factors that generate somatic mutations is therefore crucial for developing novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1818b109cb8ef8b8d489419624301e0d
https://doi.org/10.1038/s41588-020-0708-0
https://doi.org/10.1038/s41588-020-0708-0
Publikováno v:
Life Science Alliance
The retinoblastoma protein regulates mutagenic potential via control of UV-induced DNA lesion acquisition, thus revealing novel mechanisms that contribute to its tumor suppressor capabilities.
Carcinogenic insult, such as UV light exposure, crea
Carcinogenic insult, such as UV light exposure, crea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f89d9e085a14fa6b424b14220413dc
http://europepmc.org/articles/PMC8739494
http://europepmc.org/articles/PMC8739494
Autor:
Hao Zhang, Kristy Red-Horse, Nadjet Belbachir, Ian M. Williams, Virginia D. Winn, Ragini Phansalkar, Joseph C. Wu, Siyeon Rhee, Ashby J. Morrison, Mark Chandy, David T. Paik, Danielle Nagelberg, Lei Tian, Devin A. King, Robert Roth, Seokho Kim, Caroline Valdez, Jiyeon Ban, Johnson Y. Yang, Ka Man Wong
Publikováno v:
Eur Heart J
Aims Non-compaction cardiomyopathy is a devastating genetic disease caused by insufficient consolidation of ventricular wall muscle that can result in inadequate cardiac performance. Despite being the third most common cardiomyopathy, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89fa51a6b22884d985b85604d6244c2
https://europepmc.org/articles/PMC8560211/
https://europepmc.org/articles/PMC8560211/
Autor:
Alicia N. Schep, William J. Greenleaf, Devin A. King, Ka Man Wong, Ashby J. Morrison, Graeme J. Gowans
Publikováno v:
Cell reports
Cell Reports, Vol 22, Iss 3, Pp 611-623 (2018)
Cell Reports, Vol 22, Iss 3, Pp 611-623 (2018)
SUMMARY Adaptive survival requires the coordination of nutrient availability with expenditure of cellular resources. For example, in nutrient-limited environments, 50% of all S. cerevisiae genes synchronize and exhibit periodic bursts of expression i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7542290f744be17273c44da50796dbae
https://doi.org/10.1016/j.celrep.2017.12.079
https://doi.org/10.1016/j.celrep.2017.12.079
Autor:
Jae I. Chung, David T. Paik, Ashby J. Morrison, Gaetano D'Amato, Andrew Chang, Kristy Red-Horse, Danielle Nagelberg, Joseph C. Wu, Youngtae Jeong, Anna Duan, Devin A. King, Bikram Sharma, Maximilian Diehn, Siyeon Rhee
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications
During development, the formation of a mature, well-functioning heart requires transformation of the ventricular wall from a loose trabecular network into a dense compact myocardium at mid-gestation. Failure to compact is associated in humans with co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb887eebd57028b07ce2b7924907c17
https://doaj.org/article/0d8c87a059fa43f486965f124732ed10
https://doaj.org/article/0d8c87a059fa43f486965f124732ed10
Autor:
Brian S. Perez, Erin K. Schwartz, Rafael E. Herrera, Pablo E. García-Nieto, Ashby J. Morrison, Ka Man Wong, Devin A. King
Publikováno v:
Mutat Res
Exposure to the ultraviolet (UV) radiation in sunlight creates DNA lesions, which if left unrepaired can induce mutations and contribute to skin cancer. The two most common UV-induced DNA lesions are the cis-syn cyclobutane pyrimidine dimers (CPDs) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b685844a9efe6ba646a2ef1215b4f50b
https://doi.org/10.1016/j.mrfmmm.2021.111758
https://doi.org/10.1016/j.mrfmmm.2021.111758
Autor:
Ashby J. Morrison, Devin A. King, Rafael E. Herrera, Philippe Collas, Jonas Paulsen, Pablo E. García-Nieto, Erin K. Schwartz
Publikováno v:
The EMBO Journal. 36:2829-2843
The development of many sporadic cancers is directly initiated by carcinogen exposure. Carcinogens induce malignancies by creating DNA lesions (i.e., adducts) that can result in mutations if left unrepaired. Despite this knowledge, there has been rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ef96d09f73be9da8a449d06201f56a
https://doi.org/10.15252/embj.201796717
https://doi.org/10.15252/embj.201796717