Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Devika Sirohi"'
Autor:
Mayank Srivastava, Ying Zhang, Jian Chen, Devika Sirohi, Andrew Miller, Yang Zhang, Zhilu Chen, Haojie Lu, Jianqing Xu, Richard J. Kuhn, W. Andy Tao
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV rec
Externí odkaz:
https://doaj.org/article/e083ebec23fd4782a7cf7d04711ee3c2
Publikováno v:
Cell Reports, Vol 23, Iss 3, Pp 692-700 (2018)
Summary: Zika virus (ZIKV) is associated with severe neurodevelopmental impairments in human fetuses, including microencephaly. Previous reports examining neural progenitor tropism of ZIKV in organoid and animal models did not address whether the vir
Externí odkaz:
https://doaj.org/article/7b3db2d80c23423bb3d76fd0b30ce953
Autor:
Arun K. Ghosh, Dana Shahabi, Monika Yadav, Satish Kovela, Brandon J. Anson, Emma K. Lendy, Connie Bonham, Devika Sirohi, Carlos A. Brito-Sierra, Shin-ichiro Hattori, Richard Kuhn, Hiroaki Mitsuya, Andrew D. Mesecar
Publikováno v:
Molecules, Vol 26, Iss 19, p 5782 (2021)
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synth
Externí odkaz:
https://doaj.org/article/f42c479ac437463dac472853373f2de5
Autor:
Devika Sirohi, Richard J. Kuhn
Publikováno v:
mBio, Vol 8, Iss 3 (2017)
ABSTRACT Zika virus caught the world by surprise by its rapid spread and frightening disease outcomes. This major epidemic motivated many scientists to focus their attention on controlling this emerging pathogen. As many as 45 vaccine candidates are
Externí odkaz:
https://doaj.org/article/087799d59f7b43c6a462dc9d8246d579
Autor:
Theresa D'Aquila, Devika Sirohi, Jeffrey M Grabowski, Victoria E Hedrick, Lake N Paul, Andrew S Greenberg, Richard J Kuhn, Kimberly K Buhman
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126823 (2015)
Dietary fat absorption by the small intestine is a multistep process that regulates the uptake and delivery of essential nutrients and energy. One step of this process is the temporary storage of dietary fat in cytoplasmic lipid droplets (CLDs). The
Externí odkaz:
https://doaj.org/article/7f4dc2e9a9ad431c81db4d24bf3426d6
Autor:
Lauren E. Williamson, Abhishek Bandyopadhyay, Kevin Bailey, Devika Sirohi, Thomas Klose, Justin G. Julander, Richard J. Kuhn, James E. Crowe
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Selection and development of monoclonal antibody (mAb) therapeutics against pathogenic viruses depends on certain functional characteristics. Neutralization potency, or the half-maximal inhibitory concentration (IC 50 ) values, is an important charac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa3f16d75576972b8a304e684e54b8b7
https://doi.org/10.1073/pnas.2213690120
https://doi.org/10.1073/pnas.2213690120
Autor:
Kimberly A. Dowd, Devika Sirohi, Scott D. Speer, Laura A. VanBlargan, Rita E. Chen, Swati Mukherjee, Bradley M. Whitener, Jennifer Govero, Maya Aleshnick, Bridget Larman, Soila Sukupolvi-Petty, Madhumati Sevvana, Andrew S. Miller, Thomas Klose, Aihua Zheng, Scott Koenig, Margaret Kielian, Richard J. Kuhn, Michael S. Diamond, Theodore C. Pierson
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Cleavage of the flavivirus premembrane (prM) structural protein during maturation can be inefficient. The contribution of partially mature flavivirus virions that retain uncleaved prM to pathogenesis during primary infection is unknown. To investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b37c963a443eeef3f1eb9ffec0c447e
https://doi.org/10.1073/pnas.2218899120
https://doi.org/10.1073/pnas.2218899120
Autor:
Carlos A Brito-Sierra, Andrew D. Mesecar, Devika Sirohi, Satish Kovela, Monika Yadav, Hiroaki Mitsuya, Dana Shahabi, Emma K. Lendy, Arun K. Ghosh, Brandon J. Anson, Shinichiro Hattori, Richard J. Kuhn, Connie C. Bonham
Publikováno v:
Molecules
Molecules, Vol 26, Iss 5782, p 5782 (2021)
Volume 26
Issue 19
Molecules, Vol 26, Iss 5782, p 5782 (2021)
Volume 26
Issue 19
We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8da849073327a1c79bd9252806f46a20
https://pubmed.ncbi.nlm.nih.gov/34641337
https://pubmed.ncbi.nlm.nih.gov/34641337
Autor:
Devika Sirohi, Richard J. Kuhn
Publikováno v:
The Journal of Infectious Diseases. 216:S935-S944
The emergence of Zika virus (ZIKV) as a major public health threat has focused research on understanding virus biology and developing a suite of strategies for disease intervention. Recent advances in cryoelectron microscopy have accelerated structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98abb1a4b7da06a1e296178e781bf455
https://doi.org/10.1093/infdis/jix515
https://doi.org/10.1093/infdis/jix515
Autor:
Devika Sirohi, Andrew P. Miller, Ying Zhang, W. Andy Tao, Jian Chen, Mayank Srivastava, Haojie Lu, Yang Zhang, Zhilu Chen, Jianqing Xu, Richard J. Kuhn
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The outbreak of Zika virus (ZIKV) in 2016 created worldwide health emergency which demand urgent research efforts on understanding the virus biology and developing therapeutic strategies. Here, we present a time-resolved chemical proteomic strategy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77bfd4d40e4ee89f0127b042fc8e591a
https://pubmed.ncbi.nlm.nih.gov/32753727
https://pubmed.ncbi.nlm.nih.gov/32753727