Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Devika S Manickam"'
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231597 (2020)
Resident microglia of the central nervous system are being increasingly recognized as key players in diseases such as neuropathic pain. Biochemical and behavioral studies in neuropathic pain rodent models have documented compelling evidence of the cr
Externí odkaz:
https://doaj.org/article/9dce1e83338c4c578c3381aac5266bf4
Autor:
Devika S Manickam
Publikováno v:
Journal of Controlled Release. 343:400-407
The field of drug delivery has made tremendous advances in increasing the therapeutic potential of a variety of drug candidates spanning from small molecules to large molecular biologics such as nucleic acids, proteins, etc. Extracellular vesicles (E
Publikováno v:
AAPS PharmSciTech. 24
Publikováno v:
Advanced Drug Delivery Reviews. 197:114861
Autor:
Uma R. Chandran, Duncan X. Dobbins, Michael Reynolds, Courtney Sabatelle, Sruti Shiva, Yashika S. Kamte, Kandarp M. Dave, Nidia Quillinan, Anisha D'Souza, Amelia Burch, Devika S. Manickam, Wanzhu Zhao, Paco S. Herson, Vishal Soman, Aravind Sreeram, Gina M. Joy
Publikováno v:
J Control Release
We have demonstrated, for the first time that microvesicles, a sub-type of extracellular vesicles (EVs) derived from hCMEC/D3: a human brain endothelial cell (BEC) line transfer polarized mitochondria to recipient BECs in culture and to neurons in mi
Publikováno v:
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 180
Lipidoid nanoparticles (LNPs) are clinically successful carriers for nucleic acid delivery to liver and muscle targets. Their ability to load and deliver small molecule drugs has not been reported yet. We propose that the delivery of adenosine tripho
Autor:
Kandarp M. Dave, Duncan X. Dobbins, Maura N. Farinelli, Abigail Sullivan, Jadranka Milosevic, Donna B. Stolz, Jeongyun Kim, Siyang Zheng, Devika S. Manickam
Publikováno v:
Cellular and molecular bioengineering. 15(5)
Extracellular vesicles (EVs) are promising carriers for the delivery of biotherapeutic cargo such as RNA and proteins. We have previously demonstrated that the innate EV mitochondria in microvesicles (MVs), but not exosomes (EXOs) can be transferred
Autor:
Kandarp M. Dave, Donna B. Stolz, Venugopal R. Venna, Victoria A. Quaicoe, Michael E. Maniskas, Michael John Reynolds, Riyan Babidhan, Duncan X. Dobbins, Maura N. Farinelli, Abigail Sullivan, Tarun N. Bhatia, Hannah Yankello, Rohan Reddy, Younsoo Bae, Rehana K. Leak, Sruti S. Shiva, Louise D. McCullough, Devika S Manickam
Ischemic stroke causes brain endothelial cell (BEC) death and damages tight junction integrity of the blood-brain barrier (BBB). We harnessed the innate mitochondrial load of endothelial cell-derived extracellular vesicles (EVs) and utilized mixtures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bd9baa88f4bdee3a273561f9c25437
https://doi.org/10.1101/2021.10.29.466491
https://doi.org/10.1101/2021.10.29.466491
Publikováno v:
Advanced drug delivery reviews. 171
A variety of neuroprotectants have shown promise in treating ischemic stroke, yet their delivery to the brain remains a challenge. The endothelial cells lining the blood-brain barrier (BBB) are emerging as a dynamic factor in the response to neurolog
Autor:
Meredith A. Jackson, Linjiang Han, Lindsay Kadlecik, Kandarp M. Dave, Devika S. Manickam, Craig L. Duvall
Publikováno v:
Pharm Res
PURPOSE: We tested polyplexes of a diblock polymer containing a pH-responsive, endosomolytic core (dimethylaminoethyl methacrylate and butyl methacrylate; DB) and a zwitterionic Poly (methacryloyloxyethyl phosphorylcholine) (PMPC) corona for the deli