Phenyl glycine incorporated glitazones as promising novel antidiabetic agents through PPARγ agonism: Design, synthesis and preclinical studies

Autor: Subhankar Mandal, Devi Sri Chiriki, B.M. Gurupadayya, I.A. Chethan, B.R. Prashantha Kumar

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 6, Iss , Pp 100067- (2022)

Nuclear receptors function as regulators in different anabolic and catabolic pathways. PPARγ, a superfamily of nuclear receptors take part in glucose and lipid metabolism. The functional activation of PPARγ enhances insulin sensitization thereby en

Externí odkaz: https://doaj.org/article/3b8e539cd7964e568d432d94e89597e0

Updates on Intrinsic Medicinal Chemistry of 1,4-dihydropyridines, Perspectives on Synthesis and Pharmacokinetics of Novel 1,4-dihydropyrimidines as Calcium Channel Blockers: Clinical Pharmacology.

Autor: Devi Sri C; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India., Beeraka NM; Raghavendra Institute of Pharmaceutical Education and Research (RIPER), Anantapuramu, Chiyyedu, Andhra Pradesh 515721, India.; Department of Human Anatomy, I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya Street, Moscow, 119991, Russian Federation.; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, IN 46202, USA., P R HV; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.; Xenone Healthcare Pvt. Ltd, #318, Third Floor, US Complex, Jasola, New Delhi -110076., Bidye DP; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India., Kumar BRP; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India., Nikolenko VN; Herman B. Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut Street, R4-168, Indianapolis, IN 46202, USA., Bannimath G; Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS Academy of Higher Education & Research (JSS AHER), Mysuru, Karnataka, India.

Publikováno v: Current topics in medicinal chemistry [Curr Top Med Chem] 2025 Jan 01. Date of Electronic Publication: 2025 Jan 01.