Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Devi Rani Sagar"'
Autor:
Victoria Chapman, Hareklea Markides, Devi Rani Sagar, Luting Xu, James J. Burston, Paul Mapp, Alasdair Kay, Robert H. Morris, Oksana Kehoe, Alicia J. El Haj
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Background. Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi
Externí odkaz:
https://doaj.org/article/996901a5131c4477973a1519ae95039a
Autor:
James J Burston, Devi Rani Sagar, Pin Shao, Mingfeng Bai, Emma King, Louis Brailsford, Jenna M Turner, Gareth J Hathway, Andrew J Bennett, David A Walsh, David A Kendall, Aron Lichtman, Victoria Chapman
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80440 (2013)
Osteoarthritis (OA) of the joint is a prevalent disease accompanied by chronic, debilitating pain. Recent clinical evidence has demonstrated that central sensitization contributes to OA pain. An improved understanding of how OA joint pathology impact
Externí odkaz:
https://doaj.org/article/1f09b3967b034c029341bbbc8f278674
Autor:
Alasdair G. Kay, Alicia J. El Haj, Luting Xu, Hareklea Markides, Paul I. Mapp, Robert H. Morris, Oksana Kehoe, Devi Rani Sagar, James J. Burston, Victoria Chapman
Publikováno v:
Stem Cells International, Vol 2017 (2017)
Stem Cells International
Stem Cells International
Background. Mesenchymal stem cells (MSCs) have a therapeutic potential for the treatment of osteoarthritic (OA) joint pathology and pain. The aims of this study were to determine the influence of a passage number on the effects of MSCs on pain behavi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58495ab6d2b9d0efd8a17873a64ab894
https://doi.org/10.1155/2017/2905104
https://doi.org/10.1155/2017/2905104
Autor:
David A. Kendall, Devi Rani Sagar, Victoria Chapman, Catharine A. Ortori, Amy Wong, David A. Barrett
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 9, Pp 1902-1913 (2014)
Journal of Lipid Research
Journal of Lipid Research
We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups. The LC-MS/MS method uses switching at a define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acf15d3cf2d08b91b349ffe8ce869e40
http://www.sciencedirect.com/science/article/pii/S0022227520356662
http://www.sciencedirect.com/science/article/pii/S0022227520356662
Autor:
C. Bullock, David A. Walsh, Daniel F. McWilliams, Victoria Chapman, K. Paton, Gareth J. Hathway, J. Huang, R.J. Chapman, Jennifer D. Turner, Bright N Okine, Amy Wong, Stephen G. Woodhams, James J. Burston, Devi Rani Sagar, David A. Barrett, Sara Kelly
Publikováno v:
Annals of the Rheumatic Diseases
ObjectivesBlockade of transient receptor potential vanilloid 1 (TRPV1) with systemic antagonists attenuates osteoarthritis (OA) pain behaviour in rat models, but on-target-mediated hyperthermia has halted clinical trials. The present study investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59e525cda964da0923fcd2b34d753f5b
https://doi.org/10.1136/annrheumdis-2013-203413
https://doi.org/10.1136/annrheumdis-2013-203413
Publikováno v:
Philosophical Transactions of the Royal Society B: Biological Sciences. 367:3300-3311
The analgesic effects of cannabinoid ligands, mediated by CB1 receptors are well established. However, the side-effect profile of CB1 receptor ligands has necessitated the search for alternative cannabinoid-based approaches to analgesia. Herein, we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63922b020245b9ba5a4d5f75bc5bbe8d
https://doi.org/10.1098/rstb.2011.0390
https://doi.org/10.1098/rstb.2011.0390
Autor:
Stephen G. Woodhams, David A. Kendall, R.G. Pearson, Brigitte E. Scammell, Devi Rani Sagar, James J. Burston, Gareth J. Hathway, Andrew J. Bennett, Victoria Chapman
Publikováno v:
Molecular Pain, Vol 7, Iss 1, p 88 (2011)
Molecular Pain
Molecular Pain
Background: Clinical studies of osteoarthritis (OA) suggest central sensitization may contribute to the chronic pain experienced. This preclinical study used the monosodium iodoacetate (MIA) model of OA joint pain to investigate the potential contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f92cc5cf0492ad6a476f46268de1cd0
https://doi.org/10.1186/1744-8069-7-88
https://doi.org/10.1186/1744-8069-7-88
Autor:
Stephen P.H. Alexander, Brigitte E. Scammell, Lydia E Staniaszek, David A. Kendall, Michael J. Garle, Victoria Chapman, Leonie M Norris, Andrew J. Bennett, Bright N Okine, David A. Barrett, R.G. Pearson, Stephen G. Woodhams, Devi Rani Sagar
Publikováno v:
Arthritis & Rheumatism. 62:3666-3676
Objective. To investigate the impact of an experimental model of osteoarthritis (OA) on spinal nociceptive processing and the role of the inhibitory endocannabinoid system in regulating sensory processing at the spinal level. Methods. Experimental OA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1736e072d66e8cec48bd2b8a019546b7
https://doi.org/10.1002/art.27698
https://doi.org/10.1002/art.27698
Autor:
Javier Fernández-Ruiz, Eva de Lago, Maulik D. Jhaveri, Devi Rani Sagar, Royston A. Gray, David A. Barrett, Victoria Chapman, Denise Richardson, David A. Kendall
Publikováno v:
European Journal of Neuroscience. 31:1414-1422
Models of neuropathic pain are associated with elevated spinal levels of endocannabinoids (ECs) and altered expression of cannabinoid receptors on primary sensory afferents and post-synaptic cells in the spinal cord. We investigated the impact of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e36a5e87973f4906b4b9bfb04ac0eb0
https://doi.org/10.1111/j.1460-9568.2010.07162.x
https://doi.org/10.1111/j.1460-9568.2010.07162.x
Publikováno v:
British Journal of Pharmacology. 155:1297-1306
Background and purpose: We have previously demonstrated antinociceptive effects of fatty acid amide hydrolase (FAAH) inhibition that were accompanied by increases in the levels of endocannabinoids (ECs) in the hind paw. Here, the effects of the FAAH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a9548cb82e2bc080c85ba76eff18185
https://doi.org/10.1038/bjp.2008.335
https://doi.org/10.1038/bjp.2008.335