Výsledky vyhledávání - "Devi M. Gadde"

An Unassembled Subunit of NAD+-Dependent Isocitrate Dehydrogenase Is Insoluble and Covalently Modified

Autor: Mark T. McCammon, Erik Yang, Devi M. Gadde

Publikováno v: Archives of Biochemistry and Biophysics. 354:102-110

The NAD(+)-dependent isocitrate dehydrogenase of Saccharomyces cerevisiae is an octamer composed of four Idh1p subunits and four Idh2p subunits. Isocitrate dehydrogenase functions in the tricarboxylic acid cycle and has also been reported to bind to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0f9bbeab9fd93fb5d72eadbcd987587
https://doi.org/10.1006/abbi.1998.0677

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Abstract 2403: Biopsy-free comprehensive tumor profiling of 1,000+ consecutive cancer patients using CLIA-certified commercial test and its clinical utility

Autor: Dragan Sebisanovic, Devi M. Gadde, Eric A. Collisson, Reza Bayat Mokhtari, Helmy Eltoukhy, AmirAli Talasaz, Bahram G. Kermani, Heena Patel, Rene Lopez, Richard B. Lanman, Somayeh Bakhtiari, Stefanie Mortimer, Maria M. Vidamo

Publikováno v: Cancer Research. 75:2403-2403

Background: Genomic alterations of metastatic cancers may be discordant with alterations in primary tumors due to continuous evolution of disease and tumor heterogeneity. Current NGS approaches based on tissue biopsies can fail to capture a complete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57541a1439370cf40727cc147e043b8a
https://doi.org/10.1158/1538-7445.am2015-2403

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Genetic and biochemical interactions involving tricarboxylic acid cycle (TCA) function using a collection of mutants defective in all TCA cycle genes

Autor: Mark T. McCammon, Devi M. Gadde, Kurt Ducharme, Beata Przybyla-Zawislak

Publikováno v: Genetics. 152(1)

The eight enzymes of the tricarboxylic acid (TCA) cycle are encoded by at least 15 different nuclear genes in Saccharomyces cerevisiae. We have constructed a set of yeast strains defective in these genes as part of a comprehensive analysis of the int

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc397f774909810503fd4e3ed1bfffc
https://pubmed.ncbi.nlm.nih.gov/10224250

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Mutations in the IDH2 gene encoding the catalytic subunit of the yeast NAD+-dependent isocitrate dehydrogenase can be suppressed by mutations in the CIT1 gene encoding citrate synthase and other genes of oxidative metabolism

Autor: Mark T. McCammon, Devi M. Gadde

Publikováno v: Archives of biochemistry and biophysics. 344(1)

During a screen for respiration competent yeast mutants that were unable to grow with acetate as a carbon source, two idh2 cit1 double mutants were identified. These strains were defective in the catalytic subunit of the NAD(+)-dependent isocitrate d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23dab024159a5e8f99d539e9817d2078
https://pubmed.ncbi.nlm.nih.gov/9244391

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