Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Devesh Kesharwani"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 29, Iss , Pp 718-732 (2022)
Aberrant DNA methylation is associated with diabetes, but the precise regulatory events that control the levels and activity of DNA methyltransferases (DNMTs) is not well understood. Here we show that miR-539-5p targets Dnmt3b and regulates its cellu
Externí odkaz:
https://doaj.org/article/e26747770f844f7b9303278762b15c8a
Autor:
Chad C. Doucette, Daniel C. Nguyen, Davide Barteselli, Sophia Blanchard, Mason Pelletier, Devesh Kesharwani, Ed Jachimowicz, Su Su, Michele Karolak, Aaron C. Brown
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106560- (2023)
Summary: Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1). Given their propensity to stimulate weight loss and promote resistance to obesity, they are a co
Externí odkaz:
https://doaj.org/article/bb00a65367c14caf96cc8f162fbab828
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-10 (2019)
Abstract Background miR-449a, an intronic miRNA, is highly down-regulated in the skeletal muscle during diabetes. Its levels are epigenetically regulated by altered acetylation/deacetylation on the promoter that it shares with its host gene, Cdc20b.
Externí odkaz:
https://doaj.org/article/9e5570e97427430c83616e577a6610be
Publikováno v:
Molecular therapy. Nucleic acids. 29
Aberrant DNA methylation is associated with diabetes, but the precise regulatory events that control the levels and activity of DNA methyltransferases (DNMTs) is not well understood. Here we show that miR-539-5p targets
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e2fdf479f9193d205244961e59942704
https://pubmed.ncbi.nlm.nih.gov/36090753
https://pubmed.ncbi.nlm.nih.gov/36090753
Publikováno v:
Bioscience Reports
For a global epidemic like Type 2 diabetes mellitus (T2DM), while impaired gene regulation is identified as a primary cause of aberrant cellular physiology; in the past few years, non-coding RNAs (ncRNAs) have emerged as important regulators of cellu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e05314d32c61f3c1378938d589ef84ce
https://doi.org/10.1042/bsr20210495
https://doi.org/10.1042/bsr20210495
Publikováno v:
Journal of Cellular Physiology. 232:2938-2945
Epigenetics refers to functionally relevant genomic changes that do not involve changes in the basic nucleotide sequence. Majorly, these are of two types: DNA methylation and histone modifications. Small RNA molecules called miRNAs are often thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e787ca6668a7821a0fdee3dc82d94c7
https://doi.org/10.1002/jcp.25819
https://doi.org/10.1002/jcp.25819
Autor:
Rukshar Khan, Gautam Banerjee, Malabika Datta, Sudarshana Purkayastha, Devesh Kesharwani, Vinitha Kadamkode
Publikováno v:
RNA Biol
Although deregulated circulatory miRNA signatures during diabetes have been identified for some years now, the effects of such miRNAs on several target tissues are not yet thoroughly investigated. The skin that is nourished by components present in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043273b8b0093cd705b0dde46378b627
https://pubmed.ncbi.nlm.nih.gov/31615341
https://pubmed.ncbi.nlm.nih.gov/31615341
Publikováno v:
Journal of molecular medicine (Berlin, Germany). 97(1)
In a previous report from our laboratory, it was reported that hepatic levels of the long non-coding RNA (lncRNA), H19 are decreased in diabetic mice which elevates hepatic gluconeogenesis and glucose output. But, the mechanisms of H19 inhibition in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b42fdfc6b0dd01e1c918dca71431760
https://pubmed.ncbi.nlm.nih.gov/30465059
https://pubmed.ncbi.nlm.nih.gov/30465059
Publikováno v:
Cellular and molecular life sciences : CMLS. 75(10)
Type 2 diabetes is a complex metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction. Deregulated glucose and lipid metabolism are the primary underlying manifestations associated with this disease and its complicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fa505d6e73d8cb3838d85b9388852c4
https://pubmed.ncbi.nlm.nih.gov/29387902
https://pubmed.ncbi.nlm.nih.gov/29387902
microRNAs (miRNAs) are small non-coding RNAs that regulate cellular processes by fine-tuning the levels of their target mRNAs. However, the regulatory elements determining cellular miRNA levels are not well studied. Previously, we had described an al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1455827c058d9001a9a3a846d8b4738c
