Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Devendra S. Puntambekar"'
Publikováno v:
European Journal of Medicinal Chemistry. 41:1279-1292
3D-QSAR studies of some tricyclicpiperazinyl derivatives as farnesyltransferase inhibitors were performed by comparative molecular field analysis (CoMFA) and comparative molecular similarity indices (CoMSIA) methods to rationalize the structural requ
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1821-1827
3D-QSAR analysis has been performed on a series of previously synthesized benzonitrile derivatives, which were screened as farnesyltransferase inhibitors, using comparative molecular field analysis (CoMFA) with partial least-square fit to predict the
Autor:
Devendra S. Puntambekar, S. T. Shirude, Hetal. B. Prajapati, Mange Ram Yadav, Ramachandran Balaraman, Arvind Parmar, Rajani Giridhar, Pinkal J. Patel
Publikováno v:
Acta pharmaceutica (Zagreb, Croatia). 57(1)
Studies in 3,4-diaryl-1,2,5-oxadiazoles and theirN-oxides: Search for better COX-2 inhibitorsA series of 3,4-diaryl-1,2,5-oxadiazoles and 3,4-diaryl-1,2,5-oxadiazoleN-oxides were prepared and evaluated for COX-2 and COX-1 binding affinityin vitroand
Publikováno v:
Journal of enzyme inhibition and medicinal chemistry. 22(2)
This article presents in brief the development of farnesyltransferase inhibitors (FTIs) and their preclinical and clinical status. In this review the mechanism of action of FTIs is discussed and their selectivity issue towards tumor cells is also add
Autor:
Mange Ram Yadav, Shrikant T. Shirude, Devendra S. Puntambekar, Pinkal J. Patel, Hetal. B. Prajapati, Arvind Parmar, R. Balaraman, Rajani Giridhar
Publikováno v:
Acta Pharmaceutica
Volume 57
Issue 1
Volume 57
Issue 1
A series of 3,4-diaryl-1,2,5-oxadiazoles and 3,4-diaryl-1,2,5-oxadiazole N-oxides were prepared and evaluated for COX-2 and COX-1 binding affinity in vitro and for anti-inflammatory activity by the rat paw edema method. p-Methoxy (p-OMe) substituted
Publikováno v:
European journal of medicinal chemistry. 43(1)
A three-dimensional quantitative structure-activity relationship (3D-QSAR) study was performed on three different chemical series reported as selective farnesyltransferase (FTase) inhibitors employing comparative molecular field analysis (CoMFA) and