Zobrazeno 1 - 10
of 3 775
pro vyhledávání: '"Developmental Neurotoxicity"'
Publikováno v:
Environmental Chemistry and Ecotoxicology, Vol 7, Iss , Pp 84-96 (2025)
Background: The brominated flame retardant 2, 2′, 4, 4′-tetrabromodiphenyl ether (PBDE-47) is well known as a developmental neurotoxicant, yet the underlying mechanisms remain elusive. Increasing evidence has demonstrated that brain glucose metab
Externí odkaz:
https://doaj.org/article/e2ef4c4a47214731b8523334685e899f
Autor:
Ba Reum Kwon, Ah-Reum Jo, Inae Lee, Gowoon Lee, Young Joo Park, Jung Pyo Lee, Na-Youn Park, Younglim Kho, Sungkyoon Kim, Kyunghee Ji, Kyungho Choi
Publikováno v:
Environment International, Vol 192, Iss , Pp 109030- (2024)
Organic UV filters (OUVFs) have been commonly used in sunscreen and many consumer products. Following dermal application, these compounds can enter circulation and may cause systemic effects in humans. In the present study, we chose four OUVFs freque
Externí odkaz:
https://doaj.org/article/2c77ed12debe4c9fabed197bd181fc9b
Autor:
Dowlette-Mary Alam El Din, Jeongwon Shin, Alexandra Lysinger, Matthew J. Roos, Erik C. Johnson, Timothy J. Shafer, Thomas Hartung, Lena Smirnova
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
The increasing prevalence of neurodevelopmental disorders has highlighted the need for improved testing methods to determine developmental neurotoxicity (DNT) hazard for thousands of chemicals. This paper proposes the integration of organoid intellig
Externí odkaz:
https://doaj.org/article/486db674dadc4af5b5bb5bf31a061d27
Autor:
European Food Safety Authority (EFSA), Kevin M. Crofton, Martin Paparella, Anna Price, Iris Mangas, Laura Martino, Andrea Terron, Antonio Hernández‐Jerez
Publikováno v:
EFSA Journal, Vol 22, Iss 8, Pp n/a-n/a (2024)
Abstract The adverse outcome pathway (AOP) framework serves as a practical tool for organising scientific knowledge that can be used to infer cause–effect relationships between stressor events and toxicity outcomes in intact organisms. However, a m
Externí odkaz:
https://doaj.org/article/c3b3bb85a2de473da5a703e2851b6664
Autor:
Eric Witherspoon, Nicholas Zuczek, Gabrielle Williams, Briana Bernstein, Anjik Ghosh, Marko Culjat, Suhasini Kaushal, Patrick A. Forcelli
Publikováno v:
Frontiers in Pediatrics, Vol 12 (2024)
IntroductionExposure to a range of anti-seizure medications (ASMs) during early brain development adversely impacts neurodevelopmental outcomes in both animal models and in clinical studies. Many ASMs, including phenobarbital, phenytoin, valproate (V
Externí odkaz:
https://doaj.org/article/9959f71ca64c463db4add9fe3d231bb9
Autor:
Joy Ku, Prashanth Asuri
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Neurotoxicants are substances that can lead to adverse structural or functional effects on the nervous system. These can be chemical, biological, or physical agents that can cross the blood brain barrier to damage neurons or interfere with complex in
Externí odkaz:
https://doaj.org/article/2d28493bd0f14e67abb1f20dea485889
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Glyphosate-based herbicides (GBH) are a widely used group of pesticides that have glyphosate (GLY) as main active compound and are used to control a wide range of weeds. Experimental and epidemiological studies point to neurotoxicity and endocrine di
Externí odkaz:
https://doaj.org/article/dbb175cc9a41466ab8242ad48f0384e1
Autor:
EFSA (European Food Safety Authority), Antonio Hernandez‐Jerez, Tamara Coja, Martin Paparella, Anna Price, Jerome Henri, Andreas Focks, Jochem Louisse, Andrea Terron, Marco Binaglia, Irene Munoz Guajardo, Iris Mangas, Lucien Ferreira, Dimitra Kardassi, Chloe De Lentdecker, Tunde Molnar, Giorgia Vianello
Publikováno v:
EFSA Journal, Vol 22, Iss 5, Pp n/a-n/a (2024)
Abstract Acetamiprid is a pesticide active substance with insecticidal action whose approval was renewed by Commission Implementing Regulation (EU) 2018/113. In January 2022, the EFSA PPR Panel published a statement following a request from the Europ
Externí odkaz:
https://doaj.org/article/9ee7b1463abd4f499787c72727b1fe25
Autor:
Tamara Tal, Oddvar Myhre, Ellen Fritsche, Joëlle Rüegg, Kai Craenen, Kiara Aiello-Holden, Caroline Agrillo, Patrick J. Babin, Beate I. Escher, Hubert Dirven, Kati Hellsten, Kristine Dolva, Ellen Hessel, Harm J. Heusinkveld, Yavor Hadzhiev, Selma Hurem, Karolina Jagiello, Beata Judzinska, Nils Klüver, Anja Knoll-Gellida, Britta A. Kühne, Marcel Leist, Malene Lislien, Jan L. Lyche, Ferenc Müller, John K. Colbourne, Winfried Neuhaus, Giorgia Pallocca, Bettina Seeger, Ilka Scharkin, Stefan Scholz, Ola Spjuth, Monica Torres-Ruiz, Kristina Bartmann
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While the public
Externí odkaz:
https://doaj.org/article/84a7889b64d34295a7a44cec97e647b1
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