Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Devasena, Ponnalagu"'
Autor:
Rizaldy C. Zapata, Dinghong Zhang, Dongmin Yoon, Chanond A. Nasamran, Daisy R. Chilin-Fuentes, Avraham Libster, Besma S. Chaudry, Mariela Lopez-Valencia, Devasena Ponnalagu, Harpreet Singh, Michael Petrascheck, Olivia Osborn
Publikováno v:
Molecular Metabolism, Vol 76, Iss , Pp 101794- (2023)
Objective: Despite great advances in obesity therapeutics in recent years, there is still a need to identify additional therapeutic targets for the treatment of this disease. We previously discovered a signature of genes, including Chloride intracell
Externí odkaz:
https://doaj.org/article/5f67e68bed7046128845320baeb36071
Autor:
Shridhar Sanghvi, Kalina Szteyn, Devasena Ponnalagu, Divya Sridharan, Alexander Lam, Inderjot Hansra, Ankur Chaudhury, Uddalak Majumdar, Andrew R. Kohut, Shubha Gururaja Rao, Mahmood Khan, Vidu Garg, Harpreet Singh
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-13 (2022)
Abstract BKCa channels are large-conductance calcium and voltage-activated potassium channels that are heterogeneously expressed in a wide array of cells. Activation of BKCa channels present in mitochondria of adult ventricular cardiomyocytes is impl
Externí odkaz:
https://doaj.org/article/3655928a181f44399fa45ce830c02a3a
Autor:
Devasena Ponnalagu, Harpreet Singh
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Mitochondria are the source of many pro-inflammatory signals that cause the activation of the immune system and generate inflammatory responses. They are also potential targets of pro-inflammatory mediators, thus triggering a severe inflammatory resp
Externí odkaz:
https://doaj.org/article/470096e4fb7b4015800cebb51ba7196c
Autor:
Sushma Chaubey, Sam Thueson, Devasena Ponnalagu, Mohammad Afaque Alam, Ciprian P. Gheorghe, Zubair Aghai, Harpreet Singh, Vineet Bhandari
Publikováno v:
Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-26 (2018)
Abstract Background Mesenchymal stem cells (MSCs) are promising tools for the treatment of human lung disease and other pathologies relevant to newborn medicine. Recent studies have established MSC exosomes (EXO), as one of the main therapeutic vecto
Externí odkaz:
https://doaj.org/article/6b1bfdf36c284ba9af1850ea7871cba3
Autor:
Priyanka Karekar, Haley N. Jensen, Kathryn L. G. Russart, Devasena Ponnalagu, Sarah Seeley, Shridhar Sanghvi, Sakima A. Smith, Leah M. Pyter, Harpreet Singh, Shubha Gururaja Rao
Publikováno v:
Antioxidants, Vol 10, Iss 8, p 1299 (2021)
Cancer and heart diseases are the two leading causes of mortality and morbidity worldwide. Many cancer patients undergo heart-related complications resulting in high incidences of mortality. It is generally hypothesized that cardiac dysfunction in ca
Externí odkaz:
https://doaj.org/article/ae6bae2b56f54f99a8cc7e0ae0e9d332
Autor:
Shubha Gururaja Rao, Devasena Ponnalagu, Sowmya Sukur, Harkewal Singh, Shridhar Sanghvi, Yixiao Mei, Ding J. Jin, Harpreet Singh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Chloride intracellular channels (CLIC) are non-classical ion channels lacking a signal sequence for membrane targeting. In eukaryotes, they are implicated in cell volume regulation, acidification, and cell cycle. CLICs resemble the omega cla
Externí odkaz:
https://doaj.org/article/3aeea676afc6450284a8be114afbb523
Autor:
Devasena Ponnalagu, Shubha Gururaja Rao, Jason Farber, Wenyu Xin, Ahmed Tafsirul Hussain, Kajol Shah, Soichi Tanda, Mark A. Berryman, John C. Edwards, Harpreet Singh
Publikováno v:
Data in Brief, Vol 7, Iss , Pp 1038-1044 (2016)
Chloride intracellular channel (CLICs) proteins show 60–70% sequence identity to each other, and exclusively localize to the intracellular organelle membranes and cytosol. In support of our recent publication, “Molecular identity of cardiac mitoc
Externí odkaz:
https://doaj.org/article/4ca2493244e64e77a7365da665db13c5
Autor:
Sumanta Kumar Goswami, Devasena Ponnalagu, Ahmed T. Hussain, Kajol Shah, Priyanka Karekar, Shubha Gururaja Rao, Andrea L. Meredith, Mahmood Khan, Harpreet Singh
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2019)
Aims: Activation and expression of large conductance calcium and voltage-activated potassium channel (BKCa) by pharmacological agents have been implicated in cardioprotection from ischemia-reperfusion (IR) injury possibly by regulating mitochondrial
Externí odkaz:
https://doaj.org/article/1663ead0d5b34ad3b962ec65b6a40928
Autor:
Devasena Ponnalagu, Shanna Hamilton, Shridhar Sanghvi, Diego Antelo, Neill Schwieterman, Inderjot Hansra, Xianyao Xu, Erhe Gao, John C. Edwards, Shyam S. Bansal, Loren E. Wold, Dmitry Terentyev, Paul M. L. Janssen, Thomas J. Hund, Mahmood Khan, Andrew R. Kohut, Walter J. Koch, Harpreet Singh
Publikováno v:
Science Advances. 8
Mitochondrial-associated membranes (MAMs) are known to modulate organellar and cellular functions and can subsequently affect pathophysiology including myocardial ischemia-reperfusion (IR) injury. Thus, identifying molecular targets in MAMs that regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e33578b0d632c84af1f3697f03be2210
https://doi.org/10.1126/sciadv.abo1244
https://doi.org/10.1126/sciadv.abo1244
Autor:
Amit K Rai, Brooke Lee, Shridhar Sanghvi, Dhanendra Tomar, Dhananjie Chandrasekera, Sreejit Gopala Krishna, Devasena Ponnalagu, Mahmood Khan, Harpreet Singh, Prabhakara R Nagareddy, David A Goukassian, Rajesh Katare, Walter J Koch, Raj Kishore, Venkata Garikipati
Publikováno v:
Circulation Research. 131
Myocardial infarction (MI) is a significant cause of death in diabetic patients. In addition, growing evidence suggests that mitochondrial dysfunction contributes to heart failure in diabetes. However, the molecular mechanisms of mitochondrial dysfun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb2e8c68c59a2531e7ca8651758c016
https://doi.org/10.1161/res.131.suppl_1.p1036
https://doi.org/10.1161/res.131.suppl_1.p1036