Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Devaraj Venkatapura Chandrashekar"'
Publikováno v:
Fundamental & Clinical Pharmacology. 37:359-368
Midazolam (MDZ), a benzodiazepine derivative, is metabolized to 1'- and 4-hydroxylated metabolites (1'-OH-MDZ and 4-OH-MDZ, respectively) by cytochrome P450 3A (CYP3A). The purpose of this study was to investigate the CYP3A-mediated hydroxylation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ed5e524dc2db62b542540cd6bab71a
https://doi.org/10.1111/fcp.12848
https://doi.org/10.1111/fcp.12848
Autor:
Mohammad Asikur Rahman, Devaraj Venkatapura Chandrashekar, Young‐Woo Nam, Basir Syed, David Salehi, Hamidreza Montazeri Aliabadi, Miao Zhang, Reza Mehvar
Publikováno v:
Rapid Communications in Mass Spectrometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fb0086e52e10ffafb073a9d86b13a2e
https://doi.org/10.1002/rcm.9537
https://doi.org/10.1002/rcm.9537
Publikováno v:
Basicclinical pharmacologytoxicologyREFERENCES.
Chronic intraperitoneal injection of thioacetamide (TAA) in rats has been used as an animal model of human cirrhosis to study the effects of the disease on drug metabolism. However, TAA inhibits P450 enzymes directly and independently of cirrhosis. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7163e5c67c6dce8a436b2c894e4a38f2
https://pubmed.ncbi.nlm.nih.gov/36370118
https://pubmed.ncbi.nlm.nih.gov/36370118
Autor:
Nouf Alwadei, Mamunur Rashid, Devaraj Venkatapura Chandrashekar, Simin Rahighi, Jennifer Totonchy, Ajay Sharma, Reza Mehvar
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8121
The mechanisms of hepatic ischemia/reperfusion (I/R) injury, which occurs during liver transplantation or surgery, are poorly understood. The purpose of the current study was to generate and characterize a HepG2 cell line with a stable overexpression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c0cb972c4cdaa772d5c1e48400a300
https://doi.org/10.3390/ijms24098121
https://doi.org/10.3390/ijms24098121
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1180
Midazolam (MDZ) is a short-acting benzodiazepine with rapid onset of action, which is metabolized by CYP3A isoenzymes to two hydroxylated metabolites, 1′-hydroxymidazolam and 4-hydroxymidazolam. The drug is also commonly used as a marker of CYP3A a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f5a4fc294dfaa88e8bb2a8510842ab4
https://pubmed.ncbi.nlm.nih.gov/34388602
https://pubmed.ncbi.nlm.nih.gov/34388602
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 1153
Ethoxyresorufin (ER)-O-deethylation (EROD) activity has been widely used to assess cytochrome P450 1A (CYP1A) activity. The kinetics of CYP1A activity have been well characterized in the liver microsomes. However, studies in kidney microsomes are lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69820d512372b7e841b9588f9f6e64a
https://pubmed.ncbi.nlm.nih.gov/32738524
https://pubmed.ncbi.nlm.nih.gov/32738524