Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Devanshi J. Gohil"'
Publikováno v:
Medicinal Chemistry Research. 27:1013-1025
A series of chalcone derivatives (1a–2i) were designed based on isoliquiritigenin (the most active natural chalcone non-competitive neuraminidase (NA) inhibitor). Molecular modeling studies revealed that isoliquiritigenin and its designed analogs o
Autor:
Devanshi J. Gohil, Abhay Chowdhary, Sudha Srivastava, Sweta T. Kothari, Anand S. Chintakrindi, Mamata Joshi, H. Gonsalves, Khushboo D Malbari, Meena Kanyalkar
Publikováno v:
Acta virologica. 62:179-190
Considering the need for discovery of new antiviral drugs, in view to combat the issue of resistance particularly to anti-influenza drugs, a series of 2'-amino, 3'-amino and 2', 4'-dihydroxy chalcone derivatives were designed. Structure-based drug de
Autor:
Abhay Chowdhary, Rhuta Meharunkar, Devanshi J. Gohil, Rajas Warke, Sweta T. Kothari, Pramod Shinde, Ranjana A Deshmukh
Publikováno v:
Current Microbiology. 74:899-907
Pandemic influenza A (H1N1) 2009 virus was first detected in India in May 2009 which subsequently became endemic in many parts of the country. Influenza A viruses have the ability to evade the immune response through its ability of antigenic variatio
Autor:
Abhay Chowdhary, Anand S. Chintakrindi, Devanshi J. Gohil, Elvis A. F. Martis, Evans C. Coutinho, Meena Kanyalkar, Sweta T. Kothari
Publikováno v:
Current Computer Aided-Drug Design. 12:272-281
Background: With cases of emergence of drug resistance to the current competitive inhibitors of neuraminidase (NA) such as oseltamivir and zanamavir, there is a present need for an alternative approach in the treatment of avian influenza. With this i
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
We designed a series of substituted flavones and aurones as non-competitive H1N1 neuraminidase (NA) inhibitors and anti-influenza agents. The molecular docking studies showed that the designed flavones and aurones occupied 150-cavity and 430-cavity o
Autor:
Khushboo D Malbari, Sweta T. Kothari, Anand S. Chintakrindi, Meena Kanyalkar, Devanshi J. Gohil, Lata R. Ganji, Mamata Joshi
Publikováno v:
Molecular diversity. 23(4)
The rate of mutability of pathogenic H1N1 influenza virus is a threat. The emergence of drug resistance to the current competitive inhibitors of neuraminidase, such as oseltamivir and zanamivir, attributes to a need for an alternative approach. The d
Autor:
Sweta T. Kothari, Devanshi J. Gohil, Amol Chaudhari, Prasad S. Kulkarni, Bhagwat Gunale, Abhay Chowdhary, Ranjana A Deshmukh
Publikováno v:
Viral Immunology. 29:159-163
Measles, Mumps, and Rubella (MMR) are vaccine preventable viral infections, which cause significant mortality and morbidity globally. Increased incidence rates of these infectious diseases are observed in young adults. Information on seroprevalence d
Publikováno v:
Immunobiology. 220:1170-1176
Dengue, the most rampant zoonotic viral disease in tropics, contributes to 14% of acute febrile illness cases globally. Encephalitis in primary Dengue fever, with/without haemorrhage has been reported occasionally. Our study presents novel evidence f
Autor:
Anand S. Chintakrindi, Sweta T. Kothari, Pramod Shinde, Abhay Chowdhary, Meena Kanyalkar, Devanshi J. Gohil, Rhuta Meharunkar, Ranjana A Deshmukh, Rajas Warke
Publikováno v:
Infection, Genetics and Evolution. 29:75-81
Objective From its first instance in 1977, resistance to amantadine, a matrix (M2) inhibitor has been increasing among influenza A/H3N2, thus propelling the use of oseltamivir, a neuraminidase (NA) inhibitor as a next line drug. Information on drug s
Autor:
Ranjana A Deshmukh, Rhuta Meharunkar, Abhay Chowdhary, Rajas Warke, Pramod Shinde, Devanshi J. Gohil, Sweta T. Kothari, Meena Kanyalkar, Chintakrindi
Publikováno v:
Journal of Antivirals & Antiretrovirals. 7
Objectives: Oseltamivir is an important antiviral agent approved for treatment of infections caused by Influenza virus. The emergence of an Oseltamivir resistant seasonal Influenza A (H1N1) virus in 2007 in Norway and pandemic Influenza A (H1N1) viru