APOE modulates microglial immunometabolism in response to age, amyloid pathology, and inflammatory challenge.

Autor: Lee S; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA., Devanney NA; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA., Golden LR; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Smith CT; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Schwartz JL; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA., Walsh AE; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Clarke HA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, USA., Goulding DS; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA., Allenger EJ; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Morillo-Segovia G; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Friday CM; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Gorman AA; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA., Hawkinson TR; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, USA., MacLean SM; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Williams HC; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA., Sun RC; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA; Markey Cancer Center, University of Kentucky, Lexington, KY 40536, USA; Department of Biochemistry & Molecular Biology, College of Medicine, University of Florida, Gainesville, FL, USA; Center for Advanced Spatial Biomolecule Research, University of Florida, Gainesville, FL, USA., Morganti JM; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA; Department of Neuroscience, University of Kentucky, Lexington, KY 40536, USA. Electronic address: josh.morganti@uky.edu., Johnson LA; Department of Physiology, University of Kentucky, Lexington, KY 40536, USA; Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. Electronic address: johnson.lance@uky.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Mar 28; Vol. 42 (3), pp. 112196. Date of Electronic Publication: 2023 Mar 03.

APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis.

Autor: Farmer BC; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Williams HC; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA.; Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA., Devanney NA; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA.; Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA., Piron MA; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Nation GK; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Carter DJ; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Walsh AE; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Khanal R; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Young LEA; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Kluemper JC; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Hernandez G; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Allenger EJ; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Mooney R; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Golden LR; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Smith CT; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Brandon JA; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA., Gupta VA; Gill Heart and Vascular Institute, University of Kentucky, Lexington, KY, USA., Kern PA; Center for Clinical and Translational Science, University of Kentucky College of Medicine, Lexington, KY, USA.; Department of Internal Medicine, Division of Endocrinology, University of Kentucky, Lexington, KY, USA., Gentry MS; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Morganti JM; Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA.; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA., Sun RC; Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY, USA., Johnson LA; Department of Physiology, University of Kentucky College of Medicine, UKMC/MS 609, 800 Rose Street, Lexington, KY, 40536, USA. Johnson.Lance@uky.edu.; Sanders Brown Center on Aging, University of Kentucky College of Medicine, Lexington, KY, USA. Johnson.Lance@uky.edu.

Publikováno v: Molecular neurodegeneration [Mol Neurodegener] 2021 Sep 06; Vol. 16 (1), pp. 62. Date of Electronic Publication: 2021 Sep 06.