Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Devanarayanan Siva Sankar"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract Collagen has been postulated to be the most abundant protein in our body, making up one-third of the total protein content in mammals. However, a direct assessment of the total collagen levels of an entire mammal to confirm this estimate is
Externí odkaz:
https://doaj.org/article/d30fe29a12b34a62ac52396303daf5a3
Autor:
Stéphanie Kaeser-Pebernard, Christine Vionnet, Muriel Mari, Devanarayanan Siva Sankar, Zehan Hu, Carole Roubaty, Esther Martínez-Martínez, Huiyuan Zhao, Miguel Spuch-Calvar, Alke Petri-Fink, Gregor Rainer, Florian Steinberg, Fulvio Reggiori, Jörn Dengjel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
Externí odkaz:
https://doaj.org/article/47fafe05ef1d4bfc9dcefd8a49f743f9
Autor:
Mert Duman, Adrien Vaquié, Gianluigi Nocera, Manfred Heller, Michael Stumpe, Devanarayanan Siva Sankar, Jörn Dengjel, Dies Meijer, Teppei Yamaguchi, Patrick Matthias, Thomas Zeis, Nicole Schaeren-Wiemers, Antoinette Hayoz, Sophie Ruff, Claire Jacob
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The molecular mechanisms regulating remyelination are unclear. Here, the authors show that promoting deacetylation of eEF1A1 prevents the translocation of Sox10 outside the nucleus, contributing to maintaining the expression of Sox10 target genes and
Externí odkaz:
https://doaj.org/article/345079c66c764f6ca5ac313e500b3117
Autor:
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martínez-Martínez, Björn Stork, Jörn Dengjel
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109762- (2021)
Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis. To better understand control of ULK1 and analyze whether ULK1 has broader functions that are also
Externí odkaz:
https://doaj.org/article/faaa8cfccbad479e94050be695b0f084
Autor:
Priya Bhutada, Sébastien Favre, Mariam Jaafar, Jutta Hafner, Laura Liesinger, Stefan Unterweger, Karin Bischof, Barbara Darnhofer, Devanarayanan Siva Sankar, Gerald Rechberger, Raghida Abou Merhi, Simon Lebaron, Ruth Birner-Gruenberger, Dieter Kressler, Anthony K Henras, Brigitte Pertschy
Publikováno v:
Nucleic Acids Research. 50:10053-10077
Eukaryotic ribosome synthesis involves more than 200 assembly factors, which promote ribosomal RNA (rRNA) processing, modification and folding, and assembly of ribosomal proteins. The formation and maturation of the earliest pre-60S particles require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c308eb0cbc37bcc0b8e82d057bc6129e
https://doi.org/10.1093/nar/gkac724
https://doi.org/10.1093/nar/gkac724
Autor:
Jianwen Zhou, Nikoline Lander Rasmussen, Hallvard Lauritz Olsvik, Vyacheslav Akimov, Zehan Hu, Gry Evjen, Stéphanie Kaeser-Pebernard, Devanarayanan Siva Sankar, Carole Roubaty, Pauline Verlhac, Nicole van de Beek, Fulvio Reggiori, Yakubu Princely Abudu, Blagoy Blagoev, Trond Lamark, Terje Johansen, Jörn Dengjel
Publikováno v:
Zhou, J, Rasmussen, N L, Olsvik, H L, Akimov, V, Hu, Z, Evjen, G, Kaeser-Pebernard, S, Sankar, D S, Roubaty, C, Verlhac, P, van de Beck, N, Reggiori, F, Abudu, Y P, Blagoev, B, Lamark, T, Johansen, T & Dengjel, J 2023, ' TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1 ', The Journal of Cell Biology, vol. 222, no. 2, e202108144 . https://doi.org/10.1083/jcb.202108144
The Journal of Cell Biology, 222(2):e202108144. ROCKEFELLER UNIV PRESS
The Journal of Cell Biology, 222(2):e202108144. ROCKEFELLER UNIV PRESS
Limitation of excessive inflammation due to selective degradation of pro-inflammatory proteins is one of the cytoprotective functions attributed to autophagy. In the current study, we highlight that selective autophagy also plays a vital role in prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b5e9da72de2c41f9e73e7169bb3b4a
https://pure.au.dk/portal/da/publications/tbk1-phosphorylation-activates-lirdependent-degradation-of-the-inflammation-repressor-tnip1(eb658081-c42c-4782-bb7c-c9c2a3a1dd66).html
https://pure.au.dk/portal/da/publications/tbk1-phosphorylation-activates-lirdependent-degradation-of-the-inflammation-repressor-tnip1(eb658081-c42c-4782-bb7c-c9c2a3a1dd66).html
Autor:
Pierre Nivoit, Thomas Mathivet, Junxi Wu, Yann Salemkour, Devanarayanan Siva Sankar, Véronique Baudrie, Jennifer Bourreau, Anne-Laure Guihot, Emilie Vessières, Mathilde Lemitre, Cinzia Bocca, Jérémie Teillon, Morgane Le Gall, Anna Chipont, Estelle Robidel, Neeraj Dhaun, Eric Camerer, Pascal Reynier, Etienne Roux, Thierry Couffinhal, Patrick Hadoke, Jean-sébastien Silvestre, Xavier Guillonneau, Philippe Bonnin, Daniel Henrion, Jörn Dengjel, Pierre-Louis Tharaux, Olivia Lenoir
Dysregulated autophagy is associated with cardiovascular and metabolic diseases, where impaired flow-mediated endothelial cell responses promote cardiovascular risk. The mechanism by which the autophagy machinery regulates endothelial functions is co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c237327fa47b8078f174921ac2ebec32
https://doi.org/10.21203/rs.3.rs-2276541/v1
https://doi.org/10.21203/rs.3.rs-2276541/v1
Collagen has been postulated to be the most abundant protein in our body, making up one-third of the total protein content in mammals. However, to the best of our knowledge, a direct assessment of the total collagen levels of an entire mammal to conf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e07501551b9b769893b2c0a7972b08b
https://doi.org/10.1101/2022.11.21.517313
https://doi.org/10.1101/2022.11.21.517313
Autor:
Hanumanthappa Nandeesha, Senthil Kumar Subramanian, Kolar Vishwanath Vinod, Rajathi Rajendran, Devanarayanan Siva Sankar, Vivek Kumar Sharma
Publikováno v:
Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 13:652-658
Aim We aimed at assessing cardiovascular risk of first degree relatives of diabetes (FDRD). Methods A cross sectional study involving 90 apparently healthy normoglycemic volunteers aged between 15 and 50 years (45 FDRD and 45 FDRs of non-diabetics).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::829b0988a38675e5e40739fc6c12db2a
https://doi.org/10.1016/j.dsx.2018.11.047
https://doi.org/10.1016/j.dsx.2018.11.047
Autor:
Stéphanie, Kaeser-Pebernard, Christine, Vionnet, Muriel, Mari, Devanarayanan Siva, Sankar, Zehan, Hu, Carole, Roubaty, Esther, Martínez-Martínez, Huiyuan, Zhao, Miguel, Spuch-Calvar, Alke, Petri-Fink, Gregor, Rainer, Florian, Steinberg, Fulvio, Reggiori, Jörn, Dengjel
Publikováno v:
Nature communications. 13(1)
The protein kinase mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of cell growth and proliferation, supporting anabolic reactions and inhibiting catabolic pathways like autophagy. Its hyperactivation is a frequent event in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb9b6c444d5c4b19e4d7ef8087eeca36
https://pubmed.ncbi.nlm.nih.gov/35948564
https://pubmed.ncbi.nlm.nih.gov/35948564