Heterogeneous treatment effects of therapeutic-dose heparin in patients hospitalized for COVID-19

Autor: Goligher, EC, Lawler, PR, Jensen, TP, Talisa, V, Berry, LR, Lorenzi, E, McVerry, BJ, Chang, C-CH, Leifer, E, Bradbury, C, Berger, J, Hunt, BJ, Castellucci, LA, Kornblith, LZ, Gordon, AC, McArthur, C, Webb, S, Hochman, J, Neal, MD, Zarychanski, R, Berry, S, Angus, DC, Aday, A, Ahuja, T, Al-Beidh, F, Annane, D, Arabi, YM, Aryal, D, Baumann Kreuziger, L, Beane, A, Berger, JS, Berry, SM, Bhimani, Z, Bihari, S, Billett, HH, Bond, L, Bonten, M, Bradbury, CA, Brooks, MM, Brunkhorst, F, Buxton, M, Buzgau, A, Carrier, M, Castelucci, LA, Chekuri, S, Chen, J-T, Cheng, AC, Chkhikvadze, T, Coiffard, B, Contreras, A, Costantini, TW, Cushman, M, De Brouwer, S, Derde, LPG, Detry, MA, Duggal, A, Džavík, V, Effron, MB, Eng, HF, Escobedo, J, Estcourt, LJ, Everett, BM, Farkough, ME, Fergusson, DA, Fitzgerald, M, Fowler, RA, Froess, JD, Fu, Z, Galanaud, J-P, Galen, BT, Gandotra, S, Girard, TD, Godoy, LD, Gong, MN, Goodman, AL, Goossens, H, Green, C, Greenstein, YY, Gross, PL, Guerrero, RM, Hamburg, N, Haniffa, R, Hanna, G, Hanna, N, Hedge, SM, Hendrickson, CM, Higgins, AM, Hindenburg, AA, Hite, RD, Hochman, JS, Hope, AA, Horowitz, JM, Horvat, CM, Houston, BL, Huang, DT, Hudock, K, Husain, M, Hyzy, RC, Iyer, V, Jacobson, JR, Jayakumar, D, Kahn, SR, Keller, NM, Khan, A, Kim, Y, Kim, KS, Kindzelski, A, King, AJ, Kirwan, B-A, Knudson, MM, Kornblith, AE, Krishnan, V, Kumar, A, Kutcher, ME, Laffan, MA, Lamontagne, F, Le Gal, G, Leeper, CM, Leifer, ES, Lewis, RJ, Lim, G, Lima, FG, Linstrum, K, Litton, E, Lopez-Sendon, J, Lopez-Sendon Moreno, JL, Lother, SA, Madrona, SG, Malhotra, S, Marcos Martin, M, Marshall, JC, Marten, N, Martinez, AS, Martinez, M, Mateos Garcia, E, Matthay, MA, Mavromichalis, S, McArthur, CJ, McAuley, DF, McDonald, EG, McGlothlin, A, McGuinness, SP, McQuilten, ZK, Middeldorp, S, Montgomery, SK, Moore, SC, Mouncey, PR, Murthy, S, Nair, GB, Nair, R, Nichol, AD, Nicolau, JC, Nunez-Garcia, B, Pandey, A, Park, JJ, Park, PK, Parke, RL, Parker, JC, Parnia, S, Paul, JD, Pompilio, M, Prekker, M, Quigley, JG, Reynolds, HR, Rosenson, RS, Rost, NS, Rowan, K, Santos, MO, Santos, FO, Santos, M, Satterwhite, L, Saunders, CT, Schreiber, J, Schutgens, REG, Seymour, CW, Shankar Hari, M, Sheehan, JP, Siegal, DM, Silva Jr., DG, Singhal, AB, Slutsky, AS, Solvason, D, Stanworth, SJ, Tritschler, T, Turgeon, AF, Turner, AM, Van Bentum-Puijk, W, Van de Veerdonk, FL, Van Diepen, S, Vazquez Grande, G, Wahid, L, Wareham, V, Webb, SA, Wells, B, Widmer, RJ, Wilson, JG, Yuriditsky, E, Zampieri, F, Zhong, Y

Importance Randomized clinical trials (RCTs) of therapeutic-dose heparin in patients hospitalized with COVID-19 produced conflicting results, possibly due to heterogeneity of treatment effect (HTE) across individuals. Better understanding of HTE coul

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http://hdl.handle.net/10044/1/103450

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Favipiravir for COVID-19 in adults in the community in PRINCIPLE, an open-label, randomised, controlled, adaptive platform trial of short- and longer-term outcomes.

Autor: Hobbs FR; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Gbinigie-Thompson OA; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Shanyinde M; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Yu LM; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Harris V; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Dorward J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa., Hayward G; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Saville BR; Berry Consultants, TX, USA; Department of Biostatistics, Vanderbilt University School of Medicine, TN, USA., Berry NS; Berry Consultants, TX, USA., Evans PH; Department of Health and Community Sciences, University of Exeter, Exeter, UK; National Institute for Health Research (NIHR) Clinical Research Network, National Institute for Health and Care Research, Leeds, UK., Thomas NP; Royal College of General Practitioners, London, UK; National Institute for Health Research (NIHR) Clinical Research Network Thames Valley and South Midlands, National Institute for Health and Care Research, Oxford, UK., Patel MG; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Richards D; Oxford Clinical Trials Research Unit, Botnar Research Centre, University of Oxford, Oxford, UK., Hecke OV; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Detry MA; Berry Consultants, TX, USA., Saunders CT; Berry Consultants, TX, USA., Fitzgerald M; Berry Consultants, TX, USA., Robinson J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Latimer-Bell C; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Allen J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Ogburn E; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., Grabey J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK., de Lusignan S; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK; Royal College of General Practitioners, London, UK., Andersson M; Department of Microbiology, Oxford University Hospitals NHS Trust, Oxford, UK., Little P; Primary Care Research Centre, University of Southampton, UK., Butler CC; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. Electronic address: principle@phc.ox.ac.uk.

Publikováno v: The Journal of infection [J Infect] 2024 Oct; Vol. 89 (4), pp. 106248. Date of Electronic Publication: 2024 Aug 29.