Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Detlev Behnke"'
Phase 1 trial of the novel bispecific molecule H22xKi-4 in patients with refractory Hodgkin lymphoma
Autor:
Davis Thomas, Claudia Wickenhauser, Irene Fuss, Peter Borchmann, Oliver Manzke, Detlev Behnke, Volker Diehl, Lionel D. Lewis, Andreas Engert, Petra Schiller, Roland Schnell
Publikováno v:
Blood. 100:3101-3107
CD30 is an excellent target for immunotherapy of Hodgkin lymphoma (HL) because it is overexpressed on Hodgkin and Reed-Sternberg cells. We developed a novel bispecific molecule (BSM) consisting of F(ab′) fragments derived from the murine anti-CD30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1f8793d5a17c476fb2db2caf1076962
https://doi.org/10.1182/blood-2001-12-0295
https://doi.org/10.1182/blood-2001-12-0295
Autor:
Bernhard Schlott, Detlev Behnke, Ariane Gase, Karl-Heinz Gührs, Manfred Hartmann, Desire Collen, Anja Röcker
Publikováno v:
Thrombosis and Haemostasis. 76:755-760
SummaryStructure/function relationships in the activation of plasminogen with staphylokinase were studied using mutants of recombinant staphylokinase (Sak42D). Deletion of up to 10 NH2-terminal amino acids (Sak42DΔN10) did not affect plasminogen act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bda6f954ff33ef8b9c599878c2f43ab2
https://doi.org/10.1055/s-0038-1650656
https://doi.org/10.1055/s-0038-1650656
Publikováno v:
Journal of Molecular Biology. 239:466-475
Phased A-tract sequences were inserted in the upstream region of three synthetic promoters known to encompass different rate-limiting steps within the pathway of RNA polymerase-promoter interaction (Ellinger et al. , accompanying paper). Promoter P S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::376cfd8305cf8023bdfb4a1553f77d17
https://doi.org/10.1006/jmbi.1994.1389
https://doi.org/10.1006/jmbi.1994.1389
Publikováno v:
Journal of Molecular Biology. 239:455-465
Three synthetic promoters, PS1, PS2 and PS3, which differ in their core promoter elements, were studied in vivo and in vitro. Whereas an increased homology score correlates with higher rates of RNA polymerase binding, it does not correlate with activ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d61ec294a7dc976a561ee76c5b4d3caa
https://doi.org/10.1006/jmbi.1994.1388
https://doi.org/10.1006/jmbi.1994.1388
Autor:
Desire Collen, Manfred Hartmann, Detlev Behnke, Bernhard Schlott, Steven Vanderschueren, Eckhard Birch-Hirschfeid, Hans-Dieter Pohl, Frans Van de Werf, Karl-Heinz Gührs, Armand Michoel
Publikováno v:
Nature Biotechnology. 12:185-189
Recombinant plasmids were constructed in which the signal sequence of the sak42D and the sakSTAR staphylokinase genes were replaced by an ATG start codon and which express staphylokinase under the control of a tac promoter and two Shine-Dalgarno sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a795030103f741db0bfc4e8a0a31564
https://doi.org/10.1038/nbt0294-185
https://doi.org/10.1038/nbt0294-185
Publikováno v:
Journal of Basic Microbiology. 34:145-155
A proximal segment of B. subtilis secY gene was placed under the control of the inducible spac promoter/Lac repressor system. This fusion was integrated into the chromosomal spc operon of B. subtilis via Campbell-like reciprocal recombination. The gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd47d5992a873a072a9a1ceb8d7a9c1
https://doi.org/10.1002/jobm.3620340303
https://doi.org/10.1002/jobm.3620340303
Publikováno v:
Journal of Bacteriology. 175:4052-4061
Expression of the rate-limiting initiator protein RepR of plasmid pIP501 is controlled by the antisense RNAIII. Mutational alteration of individual G residues within the single-stranded loops of RNAIII led to an increase in copy number. In contrast t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1bf858092d722a4c077a855832d6cff
https://doi.org/10.1128/jb.175.13.4052-4061.1993
https://doi.org/10.1128/jb.175.13.4052-4061.1993
Publikováno v:
FEMS Microbiology Letters. 84:259-266
Several mutant hTNFα genes were constructed by deletion and stepwise reconstitution of regions coding for C-terminal sequences. The mutant hTNFα proteins behaved differently from native hTNFα when expressed in Escherichia coli. They were either se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6d968e57e70c6a11dcc686d9db552b8
https://doi.org/10.1111/j.1574-6968.1991.tb04607.x
https://doi.org/10.1111/j.1574-6968.1991.tb04607.x
Publikováno v:
Journal of Basic Microbiology. 31:329-335
In recombinant Escherichia coli strains the subcellular location of human interferon (IFN) alpha 2 and a hybrid IFN alpha 1/alpha 2 was investigated by immunogold labelling techniques. The gold label was scattered throughout the cytoplasm in cells co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22792fce84649a6fe5e8bd70f294125c
https://doi.org/10.1002/jobm.3620310505
https://doi.org/10.1002/jobm.3620310505
Publikováno v:
Gene. 93:35-40
An efficient system to control the expression of cloned genes in Bacillus subtilis was established by introducing the Escherichia coli bacteriophage lambda cI857 repressor-pR promoter system into this host. A staphylokinase reporter gene (sak42D), wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d99dda355c2c97006eb20cc4028f78fa
https://doi.org/10.1016/0378-1119(90)90132-b
https://doi.org/10.1016/0378-1119(90)90132-b