Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Detlef Siemen"'
Autor:
Piotr Bednarczyk, Mariusz R Wieckowski, Malgorzata Broszkiewicz, Krzysztof Skowronek, Detlef Siemen, Adam Szewczyk
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e68125 (2013)
Potassium channels have been found in the inner mitochondrial membranes of various cells. These channels regulate the mitochondrial membrane potential, the matrix volume and respiration. The activation of these channels is cytoprotective. In our stud
Externí odkaz:
https://doaj.org/article/09e8dc7466c542669a594cdc12c7206a
Autor:
Zuzana Berková, Monika Cahova, Vojtěch Pavluch, Detlef Siemen, Ralf P. Brandes, Martin Jabůrek, Jan Tauber, Lydie Plecitá-Hlavatá, Blanka Holendová, Katrin Schröder, Petr Ježek
Publikováno v:
Diabetes. 69:1341-1354
NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase isoform 4 (NOX4) to be the main producer of cytosolic H2O2, which is essential for GSIS;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::593c0ec6fbc3d21362c37b04fe6973b7
https://doi.org/10.2337/db19-1130
https://doi.org/10.2337/db19-1130
Autor:
Petr Ježek, Detlef Siemen, Ralf P. Brandes, Katrin Schroeder, Monika Cahová, Zuzana Berková, Vojtěch Pavluch, Jan Tauber, Blanka Holendová, Martin Jabůrek, Lydie Plecitá-Hlavatá, Ada Admin
NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islet (PI) b-cells by an as yet unknown mechanism. We found NADPH oxidase, isoform-4 (NOX4), to be the major producer of cytosolic H2O2, essential for GSIS, while the increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004cb0be56802ac602e8e81450aa64c2
https://doi.org/10.2337/db20-4567/suppl.12053772.v1
https://doi.org/10.2337/db20-4567/suppl.12053772.v1
Autor:
Lydie, Plecitá-Hlavatá, Martin, Jabůrek, Blanka, Holendová, Jan, Tauber, Vojtěch, Pavluch, Zuzana, Berková, Monika, Cahová, Katrin, Schröder, Ralf P, Brandes, Detlef, Siemen, Petr, Ježek
Publikováno v:
Diabetes. 69(7)
NADPH facilitates glucose-stimulated insulin secretion (GSIS) in pancreatic islets (PIs) of β-cells through an as yet unknown mechanism. We found NADPH oxidase isoform 4 (NOX4) to be the main producer of cytosolic H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c9e23a02c598e43b4b2d884552730cc9
https://pubmed.ncbi.nlm.nih.gov/32245800
https://pubmed.ncbi.nlm.nih.gov/32245800
Autor:
Grazyna Debska-Vielhaber, Jeffery D. Molkentin, Detlef Siemen, T. Gainutdinov, Frank N. Gellerich, Zulfiya Orynbayeva, Zemfira Gizatullina, S. Vielhaber, M. Ziemer
Publikováno v:
Archives of Biochemistry and Biophysics. 579:40-46
The mitochondrial peptidyl prolyl isomerase cyclophilin D (CypD) activates permeability transition (PT). To study the role of CypD in this process we compared the functions of brain mitochondria isolated from wild type (BMWT) and CypD knockout (Ppif(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::633f28fff118b749b4fe7948126cb70e
https://doi.org/10.1016/j.abb.2015.05.009
https://doi.org/10.1016/j.abb.2015.05.009
Publikováno v:
Protoplasma. 253:835-843
The permeability transition pore (PTP) of inner mitochondrial membranes is a large conductance pathway for ions up to 1500 Da which opening is responsible for ion equilibration and loss of membrane potential in apoptosis and thus in several neurodege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02524968cde6fc4d02b7d79c680b2980
https://doi.org/10.1007/s00709-015-0846-x
https://doi.org/10.1007/s00709-015-0846-x
Publikováno v:
Glia. 62:504-513
Tumor cells are resistant to hypoxia but the underlying mechanism(s) of this tolerance remain poorly understood. In healthy brain cells, plasmalemmal Ca(2+)-activated K(+) channels ((plasma)BK) function as oxygen sensors and close under hypoxic condi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b6b0082fe96928bdb71e1bcb9d93e0d
https://doi.org/10.1002/glia.22620
https://doi.org/10.1002/glia.22620
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1817(10):1747-1753
Existing literature on estradiol indicates that it affects mitochondrial functions at low micromolar concentrations. Particularly blockade of the permeability transition pore (PTP) or modulation of the enzymatic activity of one or more complexes of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f492c69d642e2d262cfb74ceefcb488
Activation of the Permeability Transition Pore by Bax via Inhibition of the Mitochondrial BK Channel
Publikováno v:
Cellular Physiology and Biochemistry. 27:191-200
Mitochondria are crucially involved in the intrinsic pathway of apoptosis. Upon induction of apoptosis, proapoptotic proteins of the Bcl-2 family, in particular Bax and Bak, transfer the death signal to the organelle. The outcome is release of proapo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::518b31d0081836d024cb5cd22fb962e5
https://doi.org/10.1159/000327944
https://doi.org/10.1159/000327944
Publikováno v:
FEBS Letters. 584:2005-2012
Three types of potassium channels cooperate with the permeability transition pore (PTP) in the inner mitochondrial membranes of various tissues, mtK (ATP) , mtBK, and mtKv1.3. While the latter two share similarities with their plasma membrane counter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8464b375aa12ca2fd1d9298aa184d90
https://doi.org/10.1016/j.febslet.2009.12.038
https://doi.org/10.1016/j.febslet.2009.12.038